دورية أكاديمية
The Burden and Impact of Cough in Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the Prospective Observational PROFILE Study.
| العنوان: | The Burden and Impact of Cough in Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the Prospective Observational PROFILE Study. |
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| المؤلفون: | Saunders P; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Oxford University Hospitals NHS Trust, Oxford, United Kingdom., Wu Z; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Fahy WA; Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Stewart ID; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Saini G; Centre for Respiratory Research, NIHR Biomedical Research Centre, Translational Medical Sciences, University of Nottingham, Nottingham, United Kingdom., Smith DJF; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Braybrooke R; Centre for Respiratory Research, NIHR Biomedical Research Centre, Translational Medical Sciences, University of Nottingham, Nottingham, United Kingdom., Stock C; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Renzoni EA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Johnson SR; Centre for Respiratory Research, NIHR Biomedical Research Centre, Translational Medical Sciences, University of Nottingham, Nottingham, United Kingdom., Jenkins RG; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Belvisi MG; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Respiratory and Immunology, BioPharmaceuticals Research and Development, AstraZeneca, Gothenburg, Sweden., Smith JA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, United Kingdom., Maher TM; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Hastings Centre for Pulmonary Research and Division of Pulmonary, Critical Care and Sleep Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Molyneaux PL; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. |
| المصدر: | Annals of the American Thoracic Society [Ann Am Thorac Soc] 2023 Sep; Vol. 20 (9), pp. 1267-1273. |
| نوع المنشور: | Observational Study; Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 101600811 Publication Model: Print Cited Medium: Internet ISSN: 2325-6621 (Electronic) Linking ISSN: 23256621 NLM ISO Abbreviation: Ann Am Thorac Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : American Thoracic Society, [2013]- |
| مواضيع طبية MeSH: | Cough*/epidemiology , Cough*/etiology , Cough*/diagnosis , Idiopathic Pulmonary Fibrosis*/complications, Humans ; Quality of Life ; Longitudinal Studies ; Prospective Studies ; Surveys and Questionnaires |
| مستخلص: | Rationale: Cough is a commonly reported symptom in idiopathic pulmonary fibrosis (IPF) that negatively impacts patient-reported quality of life (QoL). However, both the burden of cough at diagnosis and the behavior of cough over time have not been systematically described in patients with IPF. Objectives: By utilizing data prospectively collected as part of the PROFILE study, we sought to assess cough burden and the impact that this has on QoL within a cohort of patients with newly diagnosed IPF. We also reexamined the previously described relationship between cough and mortality and the association of cough with the MUC5B promoter polymorphism. Methods: The PROFILE study is a multicenter, prospective, observational, longitudinal cohort study of incident IPF. Scores on the Leicester Cough Questionnaire (LCQ) were recorded at baseline in 632 subjects and then repeated 6 monthly in a subset ( n = 216) of the cohort. Results: The median LCQ score at diagnosis was 16.1 (interquartile range, 6.5). LCQ scores remained stable over the subsequent year in the majority of patients. There was a weak association between LCQ score and baseline lung function, with worse cough-related QoL associated with more severe physiological impairment. Cough scores were not associated with subsequent mortality after correcting for baseline lung function. Furthermore, there was no relationship between LCQ score and MUC5B promoter polymorphism status. Conclusions: The burden of cough in IPF is high. Although cough is weakly associated with disease severity at baseline, cough-specific QoL, as measured by the LCQ, confers no prognostic value. Cough-specific QoL burden remains relatively stable over time and does not associate with MUC5B promoter polymorphism. |
| التعليقات: | Comment in: Ann Am Thorac Soc. 2023 Sep;20(9):1237-1239. (PMID: 37655956) |
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| فهرسة مساهمة: | Keywords: MUC5B; cough; interstitial lung disease; quality of life |
| تواريخ الأحداث: | Date Created: 20230509 Date Completed: 20230904 Latest Revision: 20240302 |
| رمز التحديث: | 20240302 |
| مُعرف محوري في PubMed: | PMC10502892 |
| DOI: | 10.1513/AnnalsATS.202302-174OC |
| PMID: | 37159951 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2325-6621 |
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| DOI: | 10.1513/AnnalsATS.202302-174OC |