دورية أكاديمية
أعرض في EDS

Alginate hydrogels: A potential tissue engineering intervention for intervertebral disc degeneration.

التفاصيل البيبلوغرافية
العنوان: Alginate hydrogels: A potential tissue engineering intervention for intervertebral disc degeneration.
المؤلفون: Jarrah RM; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA., Potes MDA; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA., Vitija X; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA; College of Engineering, Michigan State University, East Lansing, MI, USA., Durrani S; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA., Ghaith AK; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA., Mualem W; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA., Zamanian C; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA., Bhandarkar AR; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA., Bydon M; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address: bydon.mohamad@mayo.edu.
المصدر: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2023 Jul; Vol. 113, pp. 32-37. Date of Electronic Publication: 2023 May 07.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9433352 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2653 (Electronic) Linking ISSN: 09675868 NLM ISO Abbreviation: J Clin Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000->: Edinburgh : Churchill Livingstone
Original Publication: Melbourne, Vic., Australia : Churchill Livingstone, c1994-
مواضيع طبية MeSH: Intervertebral Disc Degeneration*/surgery , Intervertebral Disc*, Humans ; Hydrogels/therapeutic use ; Tissue Engineering ; Alginates/therapeutic use ; Biocompatible Materials/therapeutic use
مستخلص: Intervertebral disc (IVD) degeneration is a major cause of low back pain and disability, affecting millions of people worldwide. Current treatments for IVD degeneration are limited to invasive surgery or pain management. Recently, there has been increasing interest in the use of biomaterials, such as alginate hydrogels, for the treatment of IVD degeneration. Alginate hydrogels are an example of such a biomaterial that is biocompatible and can be tailored to mimic the native extracellular matrix of the IVD. Derived from alginate, a naturally derived polysaccharide from brown seaweed that can be transformed into a gelatinous solution, alginate hydrogels are emerging in the field of tissue engineering. They can be used to deliver therapeutic agents, such as growth factors or cells, to the site of injury, providing a localized and sustained release that may enhance treatment outcomes. This paper provides an overview on the use of alginate hydrogels for the treatment of IVD degeneration. We discuss the properties of alginate hydrogels and their potential applications for IVD regeneration, including the mechanism against IVD degeneration. We also highlight the research outcomes to date along with the challenges and limitations of using alginate hydrogels for IVD regeneration, including their mechanical properties, biocompatibility, and surgical compatibility. Overall, this review paper aims to provide a comprehensive overview of the current research on alginate hydrogels for IVD degeneration and to identify future directions for research in this area.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Ltd.)
فهرسة مساهمة: Keywords: Alginates; Biomaterials; Disc degeneration; Hydrogels; Spinal cord injury
المشرفين على المادة: 0 (Hydrogels)
0 (Alginates)
0 (Biocompatible Materials)
تواريخ الأحداث: Date Created: 20230509 Date Completed: 20230613 Latest Revision: 20230613
رمز التحديث: 20240628
DOI: 10.1016/j.jocn.2023.05.001
PMID: 37159956
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-2653
DOI:10.1016/j.jocn.2023.05.001