دورية أكاديمية
Plasmodium vivax infection alters the peripheral immunoregulatory network of CD4 T follicular cells and B cells.
| العنوان: | Plasmodium vivax infection alters the peripheral immunoregulatory network of CD4 T follicular cells and B cells. |
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| المؤلفون: | Ferreira NS; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Lima NF; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Sulczewski FB; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Soares IS; Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil., Ferreira MU; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, NOVA University of Lisbon, Lisbon, Portugal., Boscardin SB; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. |
| المصدر: | European journal of immunology [Eur J Immunol] 2023 Aug; Vol. 53 (8), pp. e2350372. Date of Electronic Publication: 2023 May 24. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Weinheim : Wiley-VCH Original Publication: Weinheim, Verlag Chemie GmbH. |
| مواضيع طبية MeSH: | Plasmodium vivax*/physiology , Malaria, Vivax*, Adult ; Humans ; CTLA-4 Antigen ; T-Lymphocytes, Helper-Inducer ; CD4-Positive T-Lymphocytes |
| مستخلص: | Regulatory and effector cell responses to Plasmodium vivax, the most common human malaria parasite outside Africa, remain understudied in naturally infected populations. Here, we describe peripheral CD4 + T- and B-cell populations during and shortly after an uncomplicated P. vivax infection in 38 continuously exposed adult Amazonians. Consistent with previous observations, we found an increased frequency in CD4 + CD45RA - CD25 + FoxP3 + T regulatory cells that express the inhibitory molecule CTLA-4 during the acute infection, with a sustained expansion of CD21 - CD27 - atypical memory cells within the CD19 + B-cell compartment. Both Th1- and Th2-type subsets of CXCR5 + ICOS hi PD-1 + circulating T follicular helper (cTfh) cells, which are thought to contribute to antibody production, were induced during P. vivax infection, with a positive correlation between overall cTfh cell frequency and IgG antibody titers to the P. vivax blood-stage antigen MSP1 (© 2023 Wiley-VCH GmbH.) |
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| معلومات مُعتمدة: | U19 AI089681 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: CTLA-4; Memory B cells; Plasmodium vivax; T follicular helper (Tfh) cells; T follicular regulatory (Tfr) cells |
| المشرفين على المادة: | 0 (CTLA-4 Antigen) |
| تواريخ الأحداث: | Date Created: 20230509 Date Completed: 20230814 Latest Revision: 20230815 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/eji.202350372 |
| PMID: | 37160134 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1521-4141 |
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| DOI: | 10.1002/eji.202350372 |