دورية أكاديمية
أعرض في EDS

Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer.

التفاصيل البيبلوغرافية
العنوان: Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer.
المؤلفون: Elmetwalli A; Department of Clinical Trial Research Unit and Drug Discovery, Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt. dr.prof2011@gmail.com., Hashish SM; Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt., Hassan MG; Department of Botany and Microbiology, Faculty of Science, Benha University, Benha, 33516, Egypt., El-Magd MA; Department of Anatomy, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt., El-Naggar SA; Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt., Tolba AM; Department of Anatomy, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Salama AF; Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt.
المصدر: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2023 Nov; Vol. 396 (11), pp. 3087-3099. Date of Electronic Publication: 2023 May 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer Verlag.
مواضيع طبية MeSH: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/drug therapy , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Tartrates*, Humans ; Male ; Mice ; Animals ; Tumor Necrosis Factor-alpha/metabolism ; bcl-2-Associated X Protein/metabolism ; Beclin-1/metabolism ; Beclin-1/pharmacology ; Quality of Life ; Oxidative Stress ; Liver ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/metabolism ; Antioxidants/pharmacology ; Apoptosis
مستخلص: Cancer cells can become resistant to existing treatments over time, so it is important to develop new treatments that target different pathways to stay ahead of this resistance. Many cancer treatments have severe side effects that can be debilitating and even life-threatening. Developing drugs that can effectively treat cancer while minimizing the risks of these side effects is essential for improving the quality of life of cancer patients. The study was designed to explore whether the combination of dicinnamoyl-L-tartaric (CLT) and sorafenib ((SOR), an anti-cancer drug)) could be used to treat hepatocellular carcinoma (HCC) in the animal model and to assess whether this combination would lead to changes in certain biomarkers associated with the tumour. In this study, 120 male mice were divided into 8 groups of 15 mice each. A number of biochemical parameters were measured, including liver functions, oxidative stress (malondialdehyde, (MDA); nitric oxide (NO)), and antioxidative activity (superoxide dismutase (SOD), and glutathione peroxidase (GPx)). Furthermore, the hepatic expressions of Bax, Beclin1, TNF-α, IL1β, and BCl-2 genes were evaluated by qRT-PCR. The combination of SOR and CLT was found to reduce the levels of liver enzymes, such as AST, ALT, ALP, and GGT, and reduce the pathological changes caused by DAB and PB. The upregulation of TNF-α, IL1β, and Bcl-2 genes suggests that the CLT was able to initiate an inflammatory response to combat the tumor, while the downregulation of the Bax and Beclin1 genes indicates that the CLT was able to reduce the risk of apoptosis in the liver. Furthermore, the combination therapy led to increased expression of cytokines, resulting in an enhanced anti-tumor effect.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Apoptosis; Dicinnamoyl-L-tartaric acid; Liver cancer; Oxidative stress; Sorafenib
المشرفين على المادة: W4888I119H (tartaric acid)
0 (Tumor Necrosis Factor-alpha)
0 (bcl-2-Associated X Protein)
0 (Beclin-1)
0 (Antioxidants)
0 (Tartrates)
تواريخ الأحداث: Date Created: 20230509 Date Completed: 20240415 Latest Revision: 20240419
رمز التحديث: 20240419
مُعرف محوري في PubMed: PMC10567854
DOI: 10.1007/s00210-023-02511-8
PMID: 37160480
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1912
DOI:10.1007/s00210-023-02511-8