دورية أكاديمية
أعرض في EDS

Antidiabetic and Liver Histological and Ultrastructural Effects of Cynara scolymus Leaf and Flower Head Hydroethanolic Extracts in Nicotinamide/Streptozotocin-Induced Diabetic Rats.

التفاصيل البيبلوغرافية
العنوان: Antidiabetic and Liver Histological and Ultrastructural Effects of Cynara scolymus Leaf and Flower Head Hydroethanolic Extracts in Nicotinamide/Streptozotocin-Induced Diabetic Rats.
المؤلفون: Ahmed OM; Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, P.O. 62521, Beni-Suef, Egypt., Abdel Fattah AA; Cell Biology, Histology and Genetics Division, Department of Zoology, Faculty of Science, Beni-Suef University, P.O. 62521, Beni-Suef, Egypt., Abdul-Hamid M; Cell Biology, Histology and Genetics Division, Department of Zoology, Faculty of Science, Beni-Suef University, P.O. 62521, Beni-Suef, Egypt., Abdel-Aziz AM; Zoology Department, Faculty of Science, Fayoum University, Fayoum 63514, Egypt., Sakr HI; Department of Medical Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.; Department of Medical Physiology, Medicine Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia., Damanhory AA; Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.; Department of Biochemistry, Medicine Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia., Abdel-Kawi SH; Department of Medical Histology and Cell Biology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Ghaboura N; Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia., Awad MMY; Department of Anatomy, Medicine Program, Batterjee Medical College, Jeddah, Saudi Arabia.; Department of Anatomy, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2023 Apr 25; Vol. 2023, pp. 4223026. Date of Electronic Publication: 2023 Apr 25 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: This study aims to investigate the effect of hydroethanolic extracts of Cynara scolymus (C. scolymus) leaf (CLHE) and C. scolymus flower (CFHE) on the hepatic histopathological lesions and functional biochemical changes induced by type 2 diabetes mellitus (T2DM). The rat model of T2DM was induced by intraperitoneal injection of streptozotocin (STZ) in a dose of 60 mg/kg for 15 minutes following nicotinamide (NA) (60 mg/kg). The rats were allocated into four groups: group 1 (negative control), group 2 (diabetic control), group 3 (diabetic rats supplemented with 100 mg/kg/day CLHE), and group 4 (diabetic rats supplemented with 100 mg/kg/day CFHE). Treatment with CLHE and CFHE, for the study duration of 28 days, significantly improved the deteriorated hepatic glycogen content, glycogen phosphorylase, glucose-6-phosphatase activities, serum fructosamine levels, lipid profile, aspartate transaminase activities, and alanine transaminase activities as well as serum insulin and C-peptide levels. The elevated liver lipid peroxidation and the decreased activities of superoxide dismutase and glutathione peroxidase were significantly alleviated. The elevated expression of the proinflammatory cytokine tumor necrosis factor- α in the liver of diabetic rats was significantly reduced by treatments with CLHE and CFHE. NA/STZ-induced T2DM exhibited hepatic histopathological changes in the form of disordered hepatocytes, cytoplasm dissolution, and mononuclear leukocytic infiltration. The electron microscopic ultrastructure study revealed damaged mitochondria with ill-defined cristae and fragmentation of the rough endoplasmic reticulum. Treatments with CLHE and CFHE remarkably amended these histopathological and EM ultrastructural changes. In conclusion, both CLHE and CFHE may have antidiabetic and improvement effects on the liver function and structural integrity, which may be mediated, at least in part, via suppression of inflammation and oxidative stress and enhancement of the antioxidant defence system.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Osama M. Ahmed et al.)
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تواريخ الأحداث: Date Created: 20230510 Latest Revision: 20230511
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10164244
DOI: 10.1155/2023/4223026
PMID: 37163198
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2023/4223026