دورية أكاديمية
أعرض في EDS

Cutaneous manifestations in patients with systemic lupus erythematosus: Forms at the beginning of the disease and during follow-up. Retrospective analysis.

التفاصيل البيبلوغرافية
العنوان: Cutaneous manifestations in patients with systemic lupus erythematosus: Forms at the beginning of the disease and during follow-up. Retrospective analysis.
المؤلفون: Cosentino M; Servicio de Reumatología, Hospital Interzonal General de Agudos San Martín, La Plata, Buenos Aires, Argentina. Electronic address: maxic_330@hotmail.com., Martire MV; Servicio de Reumatología, Hospital Interzonal General de Agudos San Martín, La Plata, Buenos Aires, Argentina., García L; Servicio de Reumatología, Hospital Interzonal General de Agudos San Martín, La Plata, Buenos Aires, Argentina., García MA; Servicio de Reumatología, Hospital Interzonal General de Agudos San Martín, La Plata, Buenos Aires, Argentina.
المصدر: Reumatologia clinica [Reumatol Clin (Engl Ed)] 2023 Jun-Jul; Vol. 19 (6), pp. 293-298. Date of Electronic Publication: 2023 May 08.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Doyma Country of Publication: Spain NLM ID: 101717526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2173-5743 (Electronic) Linking ISSN: 21735743 NLM ISO Abbreviation: Reumatol Clin (Engl Ed) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Barcelona?] : Elsevier Doyma
مواضيع طبية MeSH: Leukopenia* , Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/diagnosis, Female ; Humans ; Male ; Follow-Up Studies ; Research Design ; Retrospective Studies ; Adult
مستخلص: Objectives: To describe skin involvement (SI) in patients with systemic lupus erythematosus (SLE) at onset and during follow-up of the disease and to determine factors associated with SI at lupus diagnosis.
Materials and Methods: Retrospective, observational, and descriptive study, from a single centre in patients diagnosed with SLE (ACR 1982-97 or SLICC 2012 criteria). The modified Gilliam classification for SI was used. Descriptive statistics and bivariate and multivariate analysis were performed to evaluate the factors associated with SI at diagnosis of the disease.
Results: 149 patients were included, 91.3% women with a median age at diagnosis of 33 years. SI at onset of the disease occurred in 125 patients (83.9%), followed by joint involvement in 120 cases (80.5%). Non-specific skin lesions were more frequent than specific lesions, 92.8% versus 66.4%, respectively. In the bivariate analysis, a longer delay to diagnosis, the presence of joint involvement, a lower presence of thrombocytopenia, and a higher SLEDAI-2K score were associated with the presence of SI at onset of the disease. In the multivariate analysis, the variable that remained independently associated was joint involvement (OR 2.8%-95% CI 1.1-7.5, p: .04). During follow-up, 4/24 patients who had not presented SI at diagnosis and 51/125 patients who had, had at least one new skin flare (range: 1-5 outbreaks).
Conclusions: Our study demonstrates the high frequency of skin involvement in SLE, both diagnostically and evolutionarily, and confirms previously reported data regarding the existence of a skin-articular phenotype.
(Copyright © 2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
فهرسة مساهمة: Keywords: Clasificación de Gilliam; Compromiso articular; Compromiso cutáneo; Gilliam classification; Joint involvement; Lupus eritematoso sistémico; Skin involvement; Systemic lupus erythematosus
تواريخ الأحداث: Date Created: 20230510 Date Completed: 20230609 Latest Revision: 20230609
رمز التحديث: 20231215
DOI: 10.1016/j.reumae.2022.11.008
PMID: 37164883
قاعدة البيانات: MEDLINE
الوصف
تدمد:2173-5743
DOI:10.1016/j.reumae.2022.11.008