دورية أكاديمية
Pentoxifylline reduces inflammation and prevents myocardial perfusion derangements in experimental chronic Chagas' cardiomyopathy.
| العنوان: | Pentoxifylline reduces inflammation and prevents myocardial perfusion derangements in experimental chronic Chagas' cardiomyopathy. |
|---|---|
| المؤلفون: | Tanaka DM; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., Fabricio CG; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., Marin-Neto JA; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., de Barros Filho ACL; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., de Oliveira LFL; Department of Applied Physical Therapy, Institute of Health Sciences, Federal University of Triangulo Mineiro, Uberaba, Brazil., Mejia J; Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Almeida RR; Faculty of Medicine, Heart Institute (InCor), University of Sao Paulo, Sao Paulo, Brazil., de Souza Vieira R; Faculty of Medicine, Heart Institute (InCor), University of Sao Paulo, Sao Paulo, Brazil., Lopes CD; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., Batah SS; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., Moreira HT; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., de Lourdes Higuchi M; Faculty of Medicine, Heart Institute (InCor), University of Sao Paulo, Sao Paulo, Brazil., Neto EC; Faculty of Medicine, Heart Institute (InCor), University of Sao Paulo, Sao Paulo, Brazil., Fabro AT; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., Nekolla SG; Department of Nuclear Medicine at Technische Universität, Munich, Germany., Romano MMD; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil., Simões MV; Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil. msimoes@fmrp.usp.br.; Cardiology Division, Internal Medicine Department, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, 3900 Bandeirantes Avenue, Ribeirão Preto, São Paulo, 14048900, Brazil. msimoes@fmrp.usp.br. |
| المصدر: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2023 Dec; Vol. 30 (6), pp. 2327-2337. Date of Electronic Publication: 2023 May 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society of Nuclear Cardiology Country of Publication: United States NLM ID: 9423534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : New York : Elsevier Inc. on behalf of American Society of Nuclear Cardiology Original Publication: St. Louis, MO : Mosby-Year Book, Inc., c1994- |
| مواضيع طبية MeSH: | Chagas Cardiomyopathy*/diagnostic imaging , Pentoxifylline*/pharmacology , Pentoxifylline*/therapeutic use , Chagas Disease*, Cricetinae ; Animals ; Female ; Stroke Volume ; Ventricular Function, Left ; Tomography, X-Ray Computed ; Inflammation ; Perfusion |
| مستخلص: | Background: Myocardial perfusion defect (MPD) is common in chronic Chagas cardiomyopathy (CCC) and is associated with inflammation and development of left ventricular systolic dysfunction. We tested the hypothesis that pentoxifylline (PTX) could reduce inflammation and prevent the development of MPD in a model of CCC in hamsters. Methods and Results: We investigated with echocardiogram and rest myocardial perfusion scintigraphy at baseline (6-months after T. cruzi infection/saline) and post-treatment (after additional 2-months of PTX/saline administration), female Syrian hamsters assigned to 3 groups: T. cruzi-infected animals treated with PTX (CH + PTX) or saline (CH + SLN); and uninfected control animals (CO). At the baseline, all groups showed similar left ventricular ejection fraction (LVEF) and MPD areas. At post-treatment evaluation, there was a significant increase of MPD in CH + SLN group (0.8 ± 1.6 to 9.4 ± 9.7%), but not in CH + PTX (1.9 ± 3.0% to 2.7 ± 2.7%) that exhibited MPD area similar to CO (0.0 ± 0.0% to 0.0 ± 0.0%). The LVEF decreased in both infected groups. Histological analysis showed a reduced inflammatory infiltrate in CH + PTX group (395.7 ± 88.3 cell/mm 2 ), as compared to CH + SLN (515.1 ± 133.0 cell/mm 2 ), but larger than CO (193.0 ± 25.7 cell/mm 2 ). The fibrosis and TNF-α expression was higher in both infected groups. Conclusions: The prolonged use of PTX is associated with positive effects, including prevention of MPD development and reduction of inflammation in the chronic hamster model of CCC. (© 2023. The Author(s) under exclusive licence to American Society of Nuclear Cardiology.) |
| References: | Bern C, Messenger LA, Whitman JD, Maguire JH. Chagas disease in the United States: a public health approach. Clin Microbiol Rev 2019;33. Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016;388:1545‐602. (PMID: 10.1016/S0140-6736(16)31678-6) Monge-Maillo B, Lopez-Velez R. Challenges in the management of Chagas disease in Latin-American migrants in Europe. Clin Microbiol Infect 2017;23:290‐5. (PMID: 10.1016/j.cmi.2017.04.01328428122) Pérez-Molina JA, Molina I. Chagas disease. The Lancet 2018;391:82‐94. (PMID: 10.1016/S0140-6736(17)31612-4) Bocchi EA, Bestetti RB, Scanavacca MI, Cunha Neto E, Issa VS. Chronic chagas heart disease management: from etiology to cardiomyopathy treatment. J Am Coll Cardiol 2017;70:1510‐24. (PMID: 10.1016/j.jacc.2017.08.00428911515) Marin-Neto JA, Simoes MV, Rassi JA. Pathogenesis of chronic Chagas cardiomyopathy: the role of coronary microvascular derangements. Rev Soc Bras Med Trop 2013;46:536‐41. (PMID: 10.1590/0037-8682-0028-201323904079) Marin-Neto JA, Cunha-Neto E, Maciel BC, Simoes MV. Pathogenesis of chronic Chagas heart disease. Circulation 2007;115:1109‐23. (PMID: 10.1161/CIRCULATIONAHA.106.62429617339569) Petkova SB, Huang H, Factor SM, Pestell RG, Bouzahzah B, Jelicks LA, et al. The role of endothelin in the pathogenesis of Chagas’ disease. Int J Parasitol 2001;31:499‐511. (PMID: 10.1016/S0020-7519(01)00168-011334935) Rossi MA, Tanowitz HB, Malvestio LM, Celes MR, Campos EC, Blefari V et al. Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms. PLoS Negl Trop Dis 2010;4. Yan G, You B, Chen SP, Liao JK, Sun J. Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1. Circ Res 2008;103:591‐7. (PMID: 10.1161/CIRCRESAHA.108.173963186880462753820) Didion SP. Cellular and oxidative mechanisms associated with interleukin-6 signaling in the vasculature. Int J Mol Sci 2017;18. Simoes MV, Pintya AO, Bromberg-Marin G, Sarabanda AV, Antloga CM, Pazin-Filho A, et al. Relation of regional sympathetic denervation and myocardial perfusion disturbance to wall motion impairment in Chagas’ cardiomyopathy. Am J Cardiol 2000;86:975‐81. (PMID: 10.1016/S0002-9149(00)01133-411053710) Hiss FC, Lascala TF, Maciel BC, Marin-Neto JA, Simoes MV. Changes in myocardial perfusion correlate with deterioration of left ventricular systolic function in chronic Chagas’ cardiomyopathy. JACC Cardiovasc Imaging 2009;2:164‐72. (PMID: 10.1016/j.jcmg.2008.09.01219356551) Lemos de Oliveira LF, Thackeray JT, Marin Neto JA, Dias Romano MM, Vieira de Carvalho EE, Mejia J et al. Regional myocardial perfusion disturbance in experimental chronic chagas cardiomyopathy. J Nucl Med 2018;59:1430–6. Umezawa ES, Nascimento MS, Kesper N Jr, Coura JR, Borges-Pereira J, Junqueira AC, et al. Immunoblot assay using excreted-secreted antigens of Trypanosoma cruzi in serodiagnosis of congenital, acute, and chronic Chagas’ disease. J Clin Microbiol 1996;34:2143‐7. (PMID: 10.1128/jcm.34.9.2143-2147.19968862574229206) Bilate AM, Salemi VM, Ramires FJ, de Brito T, Silva AM, Umezawa ES, et al. The Syrian hamster as a model for the dilated cardiomyopathy of Chagas’ disease: a quantitative echocardiographical and histopathological analysis. Microbes Infect 2003;5:1116‐24. (PMID: 10.1016/j.micinf.2003.07.00114554253) Pereira IR, Vilar-Pereira G, Moreira OC, Ramos IP, Gibaldi D, Britto C, et al. Pentoxifylline reverses chronic experimental Chagasic cardiomyopathy in association with repositioning of abnormal CD8+ T-cell response. PLoS Negl Trop Dis 2015;9:e0003659. (PMID: 10.1371/journal.pntd.0003659257894714366205) Barros Filho ACL, Moreira HT, Dias BP, Ribeiro FFF, Tanaka DM, Schmidt A, et al. Feasibility and reference intervals assessed by conventional and speckle-tracking echocardiography in normal hamsters. Physiol Rep 2021;9:e14776. (PMID: 10.14814/phy2.14776336507897923569) Schmidt A, Dias Romano MM, Marin-Neto JA, Rao-Melacini P, Rassi A Jr, Mattos A, et al. Effects of trypanocidal treatment on echocardiographic parameters in chagas cardiomyopathy and prognostic value of wall motion score index: a BENEFIT trial echocardiographic substudy. J Am Soc Echocardiogr 2019;32:e3. Mejia J, Galvis-Alonso OY, Castro AA, Braga J, Leite JP, Simoes MV. A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging. Braz J Med Biol Res 2010;43:1160‐6. (PMID: 10.1590/S0100-879X201000750012821085887) Oliveira LF, Mejia J, Carvalho EE, Lataro RM, Frassetto SN, Fazan R Jr, et al. Myocardial infarction area quantification using high-resolution SPECT images in rats. Arq Bras Cardiol 2013;101:59‐67. (PMID: 239175073998176) Tanaka DM, de Oliveira LFL, Marin-Neto JA, Romano MMD, de Carvalho EEV, de Barros Filho ACL et al. Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy. J Nucl Cardiol 2018. Bilate AM, Salemi VM, Ramires FJ, de Brito T, Russo M, Fonseca SG, et al. TNF blockade aggravates experimental chronic Chagas disease cardiomyopathy. Microbes Infect 2007;9:1104‐13. (PMID: 10.1016/j.micinf.2007.05.01417644389) Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402‐8. (PMID: 10.1006/meth.2001.126211846609) Konrad FM, Neudeck G, Vollmer I, Ngamsri KC, Thiel M, Reutershan J. Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A2A dependent. FASEB J 2013;27:3524‐35. (PMID: 10.1096/fj.13-22812223699177) Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, et al. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS ONE 2011;6:e14525. (PMID: 10.1371/journal.pone.0014525212642933021513) Zhang X, Meng F, Song J, Zhang L, Wang J, Li D, et al. Pentoxifylline ameliorates cardiac fibrosis, pathological hypertrophy, and cardiac dysfunction in angiotensin II-induced hypertensive rats. J Cardiovasc Pharmacol 2016;67:76‐85. (PMID: 10.1097/FJC.000000000000031626340750) Ferreira RC, Ianni BM, Abel LC, Buck P, Mady C, Kalil J, et al. Increased plasma levels of tumor necrosis factor-α α α α α in asymptomatic/“indeterminate” and Chagas disease cardiomyopathy patients. Mem Inst Oswaldo Cruz 2003;98:6. (PMID: 10.1590/S0074-02762003000300021) Cunha-Neto E, Nogueira LG, Teixeira PC, Ramasawmy R, Drigo SA, Goldberg AC, et al. Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy. Mem Inst Oswaldo Cruz 2009;104:252‐8. (PMID: 10.1590/S0074-0276200900090003219753481) Algoet M, Janssens S, Himmelreich U, Gsell W, Pusovnik M, Van den Eynde J et al. Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med 2022. Hammerschmidt DE, Kotasek D, McCarthy T, Huh PW, Freyburger G, Vercellotti GM. Pentoxifylline inhibits granulocyte and platelet function, including granulocyte priming by platelet activating factor. J Lab Clin Med 1988;112:254‐63. (PMID: 2840477) Ferrari E, Fioravanti M, Patti AL, Viola C, Solerte SB. Effects of long-term treatment (4 years) with pentoxifylline on haemorheological changes and vascular complications in diabetic patients. Pharmatherapeutica 1987;5:26‐39. (PMID: 3602021) Vilar-Pereira G, Resende Pereira I, de Souza Ruivo LA, Cruz Moreira O, da Silva AA, Britto C, et al. Combination chemotherapy with suboptimal doses of benznidazole and pentoxifylline sustains partial reversion of experimental Chagas’ heart disease. Antimicrob Agents Chemother 2016;60:4297‐309. (PMID: 10.1128/AAC.02123-15271616384914640) Burleigh BA, Andrews NW. The mechanisms of Trypanosoma cruzi invasion of mammalian cells. Annu Rev Microbiol 1995;49:175‐200. (PMID: 10.1146/annurev.mi.49.100195.0011358561458) Andrade LO, Machado CR, Chiari E, Pena SD, Macedo AM. Trypanosoma cruzi: role of host genetic background in the differential tissue distribution of parasite clonal populations. Exp Parasitol 2002;100:269‐75. (PMID: 10.1016/S0014-4894(02)00024-312128054) Pereira IR, Vilar-Pereira G, Silva AA, Lannes-Vieira J. Severity of chronic experimental Chagas’ heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease. Mem Inst Oswaldo Cruz 2014;109:289‐98. (PMID: 10.1590/0074-0276140033249370484131780) da Silva MV, de Almeida VL, de Oliveira WD, Matos Cascudo NC, de Oliveira PG, da Silva CA, et al. Upregulation of cardiac IL-10 and downregulation of IFN-gamma in Balb/c IL-4(-/-) in acute Chagasic myocarditis due to colombian strain of trypanosoma cruzi. Mediators Inflamm 2018;2018:3421897. (PMID: 10.1155/2018/3421897306224306304210) Cunha-Neto E, Chevillard C. Chagas disease cardiomyopathy: immunopathology and genetics. Mediators Inflamm 2014;2014:683230. (PMID: 10.1155/2014/683230252102304152981) Lewis MD, Kelly JM. Putting infection dynamics at the heart of Chagas disease. Trends Parasitol 2016;32:899‐911. (PMID: 10.1016/j.pt.2016.08.009276126515086431) Lewis MD, Francisco AF, Taylor MC, Jayawardhana S, Kelly JM. Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy. Cell Microbiol 2016;18:1429‐43. (PMID: 10.1111/cmi.12584269188035031194) Schwartz RG, Wexler O. Early identification and monitoring progression of Chagas’ cardiomyopathy with SPECT myocardial perfusion imaging. JACC Cardiovasc Imaging 2009;2:173‐5. (PMID: 10.1016/j.jcmg.2008.12.00219356552) |
| فهرسة مساهمة: | Keywords: Chronic Chagas cardiomyopathy; coronary microcirculation; hamsters; inflammation; ventricular dysfunction |
| المشرفين على المادة: | SD6QCT3TSU (Pentoxifylline) |
| تواريخ الأحداث: | Date Created: 20230510 Date Completed: 20231128 Latest Revision: 20240515 |
| رمز التحديث: | 20240516 |
| DOI: | 10.1007/s12350-023-03270-y |
| PMID: | 37165114 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1532-6551 |
|---|---|
| DOI: | 10.1007/s12350-023-03270-y |