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Efficacy of zinc supplementation for the treatment of dysmenorrhoea: a double-blind randomised controlled trial.

التفاصيل البيبلوغرافية
العنوان: Efficacy of zinc supplementation for the treatment of dysmenorrhoea: a double-blind randomised controlled trial.
المؤلفون: Obiagwu HI; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Eleje GU; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.; Effective Care Research Units, Department of Obstetrics and Gynaecology, Nnamdi, Azikiwe University, Nnewi Campus, Nigeria., Obiechina NJA; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Nwosu BO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Udigwe GO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.; Effective Care Research Units, Department of Obstetrics and Gynaecology, Nnamdi, Azikiwe University, Nnewi Campus, Nigeria., Ikechebelu JI; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.; Effective Care Research Units, Department of Obstetrics and Gynaecology, Nnamdi, Azikiwe University, Nnewi Campus, Nigeria., Ugboaja JO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okoro CC; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okonkwo IO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okwuosa AO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Oguejiofor CB; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Chigbo CG; School of Public Health, University of Port-Harcourt, Rivers State, Nigeria., Ogabido CA; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okafor CC; Paediatric Surgery unit, Great Ormond Street Hospital, London, United Kingdom., Okafor CG; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.
المصدر: The Journal of international medical research [J Int Med Res] 2023 May; Vol. 51 (5), pp. 3000605231171489.
نوع المنشور: Randomized Controlled Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Nov. 2012- : London : Sage Publications
Original Publication: Northampton, Eng., Cambridge Medical Publications ltd.
مواضيع طبية MeSH: Dysmenorrhea*/drug therapy , Zinc*/therapeutic use, Female ; Humans ; Zinc Sulfate/therapeutic use ; Analgesics/therapeutic use ; Double-Blind Method ; Dietary Supplements ; Treatment Outcome
مستخلص: Objectives: To determine the efficacy of zinc sulfate supplementation in managing dysmenorrhoea.
Methods: In total, 103 high school students were randomised into an experimental arm (52 students) and a control arm (51 students) and received 40-mg zinc sulfate or placebo, respectively, over three cycles. Primary outcome measures were the mean Visual Analogue Scale score, which measured pain over three cycles, and the frequency of nausea and vomiting. Secondary outcomes were the use of additional analgesics and the frequency of allergic reactions.
Results: Fifty participants were analysed in each group. Mean pain scores were not significantly different between the groups before administering zinc sulfate therapy. Following the intervention, the mean pain scores for the treatment (2.80 ± 2.28) and placebo (3.48 ± 2.85) groups were not significantly different in the first cycle; however, scores in the treatment group were significantly better in the second (2.56 ± 1.97 vs 3.80 ± 2.77) and third (1.95 ± 1.72 vs 3.95 ± 2.82) cycles. No significant differences were observed between the groups in the nausea and vomiting incidence and the requirement for additional analgesics.
Conclusions: Zinc sulfate reduces dysmenorrhoea severity with minimal or no adverse effects, especially with more than one cycle of usage.Trial Registration Number: PACTR202105843292338. The trial is publicly available and was registered at www.pactr.org on 25 May 2021.
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فهرسة مساهمة: Keywords: Dysmenorrhoea; Visual Analogue Scale; efficacy; primary dysmenorrhoea; zinc sulfate; zinc therapy
المشرفين على المادة: J41CSQ7QDS (Zinc)
7733-02-0 (Zinc Sulfate)
0 (Analgesics)
تواريخ الأحداث: Date Created: 20230511 Date Completed: 20230512 Latest Revision: 20230619
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10184220
DOI: 10.1177/03000605231171489
PMID: 37165643
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-2300
DOI:10.1177/03000605231171489