دورية أكاديمية
Efficacy of zinc supplementation for the treatment of dysmenorrhoea: a double-blind randomised controlled trial.
العنوان: | Efficacy of zinc supplementation for the treatment of dysmenorrhoea: a double-blind randomised controlled trial. |
---|---|
المؤلفون: | Obiagwu HI; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Eleje GU; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.; Effective Care Research Units, Department of Obstetrics and Gynaecology, Nnamdi, Azikiwe University, Nnewi Campus, Nigeria., Obiechina NJA; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Nwosu BO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Udigwe GO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.; Effective Care Research Units, Department of Obstetrics and Gynaecology, Nnamdi, Azikiwe University, Nnewi Campus, Nigeria., Ikechebelu JI; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.; Effective Care Research Units, Department of Obstetrics and Gynaecology, Nnamdi, Azikiwe University, Nnewi Campus, Nigeria., Ugboaja JO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okoro CC; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okonkwo IO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okwuosa AO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Oguejiofor CB; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Chigbo CG; School of Public Health, University of Port-Harcourt, Rivers State, Nigeria., Ogabido CA; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Okafor CC; Paediatric Surgery unit, Great Ormond Street Hospital, London, United Kingdom., Okafor CG; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria. |
المصدر: | The Journal of international medical research [J Int Med Res] 2023 May; Vol. 51 (5), pp. 3000605231171489. |
نوع المنشور: | Randomized Controlled Trial; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Nov. 2012- : London : Sage Publications Original Publication: Northampton, Eng., Cambridge Medical Publications ltd. |
مواضيع طبية MeSH: | Dysmenorrhea*/drug therapy , Zinc*/therapeutic use, Female ; Humans ; Zinc Sulfate/therapeutic use ; Analgesics/therapeutic use ; Double-Blind Method ; Dietary Supplements ; Treatment Outcome |
مستخلص: | Objectives: To determine the efficacy of zinc sulfate supplementation in managing dysmenorrhoea. Methods: In total, 103 high school students were randomised into an experimental arm (52 students) and a control arm (51 students) and received 40-mg zinc sulfate or placebo, respectively, over three cycles. Primary outcome measures were the mean Visual Analogue Scale score, which measured pain over three cycles, and the frequency of nausea and vomiting. Secondary outcomes were the use of additional analgesics and the frequency of allergic reactions. Results: Fifty participants were analysed in each group. Mean pain scores were not significantly different between the groups before administering zinc sulfate therapy. Following the intervention, the mean pain scores for the treatment (2.80 ± 2.28) and placebo (3.48 ± 2.85) groups were not significantly different in the first cycle; however, scores in the treatment group were significantly better in the second (2.56 ± 1.97 vs 3.80 ± 2.77) and third (1.95 ± 1.72 vs 3.95 ± 2.82) cycles. No significant differences were observed between the groups in the nausea and vomiting incidence and the requirement for additional analgesics. Conclusions: Zinc sulfate reduces dysmenorrhoea severity with minimal or no adverse effects, especially with more than one cycle of usage.Trial Registration Number: PACTR202105843292338. The trial is publicly available and was registered at www.pactr.org on 25 May 2021. |
References: | Aust N Z J Obstet Gynaecol. 2015 Aug;55(4):369-73. (PMID: 26132140) Med Hypotheses. 2007;69(2):297-301. (PMID: 17289285) J Pediatr Adolesc Gynecol. 2006 Dec;19(6):363-71. (PMID: 17174824) BMJ Clin Evid. 2007 Mar 01;2007:. (PMID: 19454059) Int J Gynaecol Obstet. 2008 Jan;100(1):13-7. (PMID: 17888923) Pain Manag Nurs. 2014 Dec;15(4):826-33. (PMID: 24559600) Obstet Gynecol Sci. 2013 Jul;56(4):242-8. (PMID: 24328009) Physiol Rev. 1993 Jan;73(1):79-118. (PMID: 8419966) J Am Board Fam Pract. 2004 Nov-Dec;17 Suppl:S43-7. (PMID: 15575029) Am J Obstet Gynecol. 1982 Nov 15;144(6):655-60. (PMID: 7137249) BMJ. 2010 Mar 23;340:c332. (PMID: 20332509) J Obstet Gynaecol Res. 2018 Nov;44(11):2101-2109. (PMID: 30043399) J Pediatr Adolesc Gynecol. 2010 Oct;23(5):267-72. (PMID: 20493741) Obstet Gynecol. 2006 Aug;108(2):428-41. (PMID: 16880317) Oman Med J. 2016 Mar;31(2):107-11. (PMID: 27168920) BMJ. 2006 May 13;332(7550):1134-8. (PMID: 16690671) J Pediatr Adolesc Gynecol. 2001 Feb;14(1):3-8. (PMID: 11358700) Med Hypotheses. 2006;66(1):169-72. (PMID: 16084666) Cochrane Database Syst Rev. 2010 Jan 20;(1):CD001751. (PMID: 20091521) Pediatr Endocrinol Rev. 2015 Dec;13(2):512-20. (PMID: 26841639) Cochrane Database Syst Rev. 2007 Jul 18;(3):CD002248. (PMID: 17636702) |
فهرسة مساهمة: | Keywords: Dysmenorrhoea; Visual Analogue Scale; efficacy; primary dysmenorrhoea; zinc sulfate; zinc therapy |
المشرفين على المادة: | J41CSQ7QDS (Zinc) 7733-02-0 (Zinc Sulfate) 0 (Analgesics) |
تواريخ الأحداث: | Date Created: 20230511 Date Completed: 20230512 Latest Revision: 20230619 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10184220 |
DOI: | 10.1177/03000605231171489 |
PMID: | 37165643 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1473-2300 |
---|---|
DOI: | 10.1177/03000605231171489 |