دورية أكاديمية
Obesity alters monocyte developmental trajectories to enhance metastasis.
| العنوان: | Obesity alters monocyte developmental trajectories to enhance metastasis. |
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| المؤلفون: | McDowell SAC; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Physiology, McGill University, Montreal, Canada., Milette S; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada., Doré S; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Human Genetics, McGill University, Montreal, Canada., Yu MW; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Physiology, McGill University, Montreal, Canada., Sorin M; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Human Genetics, McGill University, Montreal, Canada., Wilson L; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Physiology, McGill University, Montreal, Canada., Desharnais L; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Human Genetics, McGill University, Montreal, Canada., Cristea A; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada., Varol O; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada., Atallah A; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada., Swaby A; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada., Breton V; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada., Arabzadeh A; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada., Petrecca S; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada., Loucif H; Department of Microbiology and Immunology, McGill University, Montreal, Canada.; McGill University Research Centre on Complex Traits , Montreal, Canada., Bhagrath A; Department of Physiology, McGill University, Montreal, Canada.; McGill University Research Centre on Complex Traits , Montreal, Canada., De Meo M; Department of Experimental Surgery, McGill University, Montreal, Canada., Lach KD; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Canada., Issac MSM; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Canada., Fiset B; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada., Rayes RF; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada., Mandl JN; Department of Physiology, McGill University, Montreal, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada.; McGill University Research Centre on Complex Traits , Montreal, Canada., Fritz JH; Department of Microbiology and Immunology, McGill University, Montreal, Canada.; McGill University Research Centre on Complex Traits , Montreal, Canada., Fiset PO; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Canada., Holt PR; Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New Nork, NY, USA., Dannenberg AJ; Department of Medicine (retired), Weill Cornell Medical College, New York, NY, USA., Spicer JD; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada.; Department of Surgery, McGill University Health Centre, Montreal, Canada., Walsh LA; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Human Genetics, McGill University, Montreal, Canada., Quail DF; Rosalind and Morris Goodman Cancer Institute , Montreal, Canada.; Department of Physiology, McGill University, Montreal, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada. |
| المصدر: | The Journal of experimental medicine [J Exp Med] 2023 Aug 07; Vol. 220 (8). Date of Electronic Publication: 2023 May 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
| مواضيع طبية MeSH: | Lung Neoplasms*/pathology , Breast Neoplasms*/pathology, Humans ; Female ; Monocytes/pathology ; Obesity/metabolism ; Myeloid Cells/metabolism ; Inflammation |
| مستخلص: | Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis and mortality. Obesity promotes breast cancer metastasis to lung in a neutrophil-dependent manner; however, the upstream regulatory mechanisms of this process remain unknown. Here, we show that obesity-induced monocytes underlie neutrophil activation and breast cancer lung metastasis. Using mass cytometry, obesity favors the expansion of myeloid lineages while restricting lymphoid cells within the peripheral blood. RNA sequencing and flow cytometry revealed that obesity-associated monocytes resemble professional antigen-presenting cells due to a shift in their development and exhibit enhanced MHCII expression and CXCL2 production. Monocyte induction of the CXCL2-CXCR2 axis underlies neutrophil activation and release of neutrophil extracellular traps to promote metastasis, and enhancement of this signaling axis is observed in lung metastases from obese cancer patients. Our findings provide mechanistic insight into the relationship between obesity and cancer by broadening our understanding of the interactive role that myeloid cells play in this process. (© 2023 McDowell et al.) |
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| معلومات مُعتمدة: | Canada CIHR |
| تواريخ الأحداث: | Date Created: 20230511 Date Completed: 20230515 Latest Revision: 20231112 |
| رمز التحديث: | 20231112 |
| مُعرف محوري في PubMed: | PMC10182775 |
| DOI: | 10.1084/jem.20220509 |
| PMID: | 37166450 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1540-9538 |
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| DOI: | 10.1084/jem.20220509 |