دورية أكاديمية
أعرض في EDS

Clinical Course and Outcome of Cardiovascular Manifestations in Children With Multisystem Inflammatory Syndrome Associated With SARS-CoV-2 Infection in Georgia.

التفاصيل البيبلوغرافية
العنوان: Clinical Course and Outcome of Cardiovascular Manifestations in Children With Multisystem Inflammatory Syndrome Associated With SARS-CoV-2 Infection in Georgia.
المؤلفون: Phirtskhalava S; American MD Program, Tbilisi State Medical University, Tbilisi, GEO., Shavgulidze E; American MD Program, Tbilisi State Medical University, Tbilisi, GEO., Shaikh AAA; American MD Program, Tbilisi State Medical University, Tbilisi, GEO., Marikar F; American MD Program, Tbilisi State Medical University, Tbilisi, GEO., Kalatozishvili K; Faculty of Psychology and Educational Sciences, Tbilisi State University, Tbilisi, GEO., Maghradze A; Pediatrics, M.Iashvili Children's Central Hospital, Tbilisi, GEO., Chkhaidze I; Pediatrics, M.Iashvili Children's Central Hospital, Tbilisi, GEO.
المصدر: Cureus [Cureus] 2023 May 04; Vol. 15 (5), pp. e38555. Date of Electronic Publication: 2023 May 04 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: A SARS-CoV-2 infection is usually characterized by a very mild clinical course in the pediatric population. However, children can be severely affected, and clinical manifestations may differ from adults, mainly in terms of post-COVID-19 infection complications already known as multisystem inflammatory syndrome in children (MIS-C). As the name suggests, this condition involves many systems, including the cardiovascular system, clinical manifestations of which include myocarditis, coronary artery aneurysms, conduction abnormalities, and arrhythmias. This research aims to define the cardiac manifestations caused by multi-inflammatory processes occurring after acute SARS-CoV-2 infection, possibly find a correlation between a certain cardiac abnormality and inflammatory markers, and evaluate the dynamics of cardiovascular complications and how treatment affects it. From February 2020 to March 2022, 103 patients with MIS-C were hospitalized and treated at M.Iashvili Children's Central Hospital, Tbilisi, Georgia. Based on our results, 55% of them had cardiovascular involvement with various manifestations involving coronary artery dilation, valvular insufficiencies, heart rate abnormalities, and pericardial effusion. Our study revealed that only one statistically significant correlation was observed between D-dimer levels and heart rate abnormalities, but there was no correlation between these two values. All of the MIS-C patients reported in our study have received standardized treatment courses with steroids, intravenous immune globulin (IVIG), or IVIG combined with steroids; each patient's illness has resolved without any sequelae, and cardiac manifestations have returned to baseline. Nevertheless, systematic longer-term follow-up is needed to provide clarity on the evolution of medium- and long-term cardiac outcomes in MIS-C.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2023, Phirtskhalava et al.)
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فهرسة مساهمة: Keywords: arrhythmias; cardiology; coronary dilation; mis-c; sars-cov-2; valvular insufficiency
تواريخ الأحداث: Date Created: 20230511 Latest Revision: 20230514
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10166301
DOI: 10.7759/cureus.38555
PMID: 37168408
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.38555