دورية أكاديمية
Predictors of successful salvage microdissection testicular sperm extraction (mTESE) after failed initial TESE in patients with non-obstructive azoospermia: A systematic review and meta-analysis.
العنوان: | Predictors of successful salvage microdissection testicular sperm extraction (mTESE) after failed initial TESE in patients with non-obstructive azoospermia: A systematic review and meta-analysis. |
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المؤلفون: | Zhang F; Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, China., Dai M; Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, China., Yang X; Department of Nursing, Tianjin Central Obstetrics and Gynecology Hospital, Tianjin, China., Cheng Y; College of Pharmacy, Tianjin Medical University, Tianjin, China., Ye L; Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China., Huang W; Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China., Chen X; Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, China., Yin T; Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, China., Sha Y; Department of Andrology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.; Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China. |
المصدر: | Andrology [Andrology] 2024 Jan; Vol. 12 (1), pp. 30-44. Date of Electronic Publication: 2023 May 22. |
نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101585129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-2927 (Electronic) Linking ISSN: 20472919 NLM ISO Abbreviation: Andrology Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell, 2013- |
مواضيع طبية MeSH: | Azoospermia*/surgery , Azoospermia*/pathology , Oligospermia*/pathology , Sertoli Cell-Only Syndrome*, Humans ; Male ; Retrospective Studies ; Microdissection/methods ; Sperm Retrieval ; Semen ; Testis/surgery ; Testis/pathology ; Spermatozoa/pathology ; Follicle Stimulating Hormone ; Luteinizing Hormone ; Follicle Stimulating Hormone, Human |
مستخلص: | Background: There has been no systematic review and meta-analysis to analyze and summarize the predictive factors of successful sperm extraction in salvage microdissection testicular sperm extraction. Objectives: We aimed to investigate the factors predicting the result of salvage microdissection testicular sperm extraction in patients with non-obstructive azoospermia who failed the initial microdissection testicular sperm extraction or conventional testicular sperm extraction. Materials and Methods: We conducted a systematic literature search in PubMed, Web of Science, EMBASE, and the Cochrane Library for literature that described the characteristics of patients with non-obstructive azoospermia who underwent salvage microdissection testicular sperm extraction after failing the initial microdissection testicular sperm extraction or conventional testicular sperm extraction published prior to June 2022. Results: This meta-analysis included four retrospective studies with 332 patients with non-obstructive azoospermia who underwent a failed initial microdissection testicular sperm extraction and three retrospective studies with 177 non-obstructive azoospermia patients who underwent a failed conventional testicular sperm extraction. The results were as follows: among non-obstructive azoospermia patients whose first surgery was microdissection testicular sperm extraction, younger patients (standard mean difference: -0.28, 95% confidence interval [CI]: -0.55 to -0.01) and those with smaller bilateral testicular volume (standard mean difference: -0.55, 95% CI: -0.95 to -0.15), lower levels of follicle-stimulating hormone (standard mean difference: -0.86, 95% CI: -1.18 to -0.54) and luteinizing hormone (standard mean difference: -0.68, 95% CI: -1.16 to -0.19), and whose testicular histological type was hypospermatogenesis (odds ratio: 3.52, 95% CI: 1.30-9.53) were more likely to retrieve spermatozoa successfully, while patients with Sertoli-cell-only syndrome (odds ratio: 0.41, 95% CI: 0.24-0.73) were more likely to fail again in salvage microdissection testicular sperm extraction. Additionally, in patients who underwent salvage microdissection testicular sperm extraction after a failed initial conventional testicular sperm extraction, those with testicular histological type of hypospermatogenesis (odds ratio: 30.35, 95% CI: 8.27-111.34) were more likely to be successful, while those with maturation arrest (odds ratio: 0.39, 95% CI: 0.18-0.83) rarely benefited. Conclusion: We found that age, testicular volume, follicle-stimulating hormone, luteinizing hormone, hypospermatogenesis, Sertoli-cell-only syndrome, and maturation arrest were valuable predictors of salvage microdissection testicular sperm extraction, which will assist andrologists in clinical decision-making and minimize unnecessary injury to patients. (© 2023 American Society of Andrology and European Academy of Andrology.) |
References: | Dabaja AA, Schlegel PN. Microdissection testicular sperm extraction: an update. Asian J Androl. 2013;15(1):35-39. https://doi.org/10.1038/aja.2012.141. Jarow JP, Espeland MA, Lipshultz LI. Evaluation of the azoospermic patient. J Urol. 1989;142(1):62-65. https://doi.org/10.1016/s0022-5347(17)38662-7. Kızılay F, Semerci B, Şimşir A, Kalemci S, Altay B. Analysis of factors affecting repeat microdissection testicular sperm extraction outcomes in infertile men. Turk J Urol. 2019;45(Suppl 1):S1-S6. https://doi.org/10.5152/tud.2019.76009. Depenbusch M, von Eckardstein S, Simoni M, Nieschlag E. Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone. Eur J Endocrinol. 2002;147(5):617-624. https://doi.org/10.1530/eje.0.1470617. Bernie AM, Mata DA, Ramasamy R, Schlegel PN. Comparison of microdissection testicular sperm extraction, conventional testicular sperm extraction, and testicular sperm aspiration for nonobstructive azoospermia: a systematic review and meta-analysis. Fertil Steril. 2015;104(5):1099-1103.e1-e3 https://doi.org/10.1016/j.fertnstert.2015.07.1136. Turunc T, Gul U, Haydardedeoglu B, et al. Conventional testicular sperm extraction combined with the microdissection technique in nonobstructive azoospermic patients: a prospective comparative study. Fertil Steril. 2010;94(6):2157-2160. https://doi.org/10.1016/j.fertnstert.2010.01.008. Schlegel PN, Sigman M, Collura B, et al. Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II. J Urol. 2021;205(1):44-51. https://doi.org/10.1097/ju.0000000000001520. Corona G, Minhas S, Giwercman A, et al. Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(6):733-757. https://doi.org/10.1093/humupd/dmz028. Yucel C, Budak S, Keskin MZ, Kisa E, Kozacioglu Z. Predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed mTESE in patients with non-obstructive azoospermia: Long-term experience at a single institute. Arch Ital Urol Androl. 2018;90(2):136-140. https://doi.org/10.4081/aiua.2018.2.136. Vernaeve V, Verheyen G, Goossens A, Van Steirteghem A, Devroey P, Tournaye H. How successful is repeat testicular sperm extraction in patients with azoospermia? Hum Reprod. 2006;21(6):1551-1554. https://doi.org/10.1093/humrep/del012. Yücel C, Budak S, Keskin MZ, Kisa E, Kozacioglu Z. Predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed mTESE in patients with non-obstructive azoospermia: Long-term experience at a single institute. Arch Ital Urol Androl. 2018;90(2):136-140. https://doi.org/10.4081/aiua.2018.2.136. Shiraishi K, Ohmi C, Shimabukuro T, Matsuyama H. Human chorionic gonadotrophin treatment prior to microdissection testicular sperm extraction in non-obstructive azoospermia. Hum Reprod. 2012;27(2):331-339. https://doi.org/10.1093/humrep/der404. Özman O, Tosun S, Bayazıt N, Cengiz S, Bakırcıoğlu ME. Efficacy of the second micro-testicular sperm extraction after failed first micro-testicular sperm extraction in men with nonobstructive azoospermia. Fertil Steril. 2021;115(4):915-921. https://doi.org/10.1016/j.fertnstert.2020.10.005. Amer MK, Ahmed AR, Hamid AAA, GamalEl Din SF. Factors determining the sperm retrieval rate in fresh versus salvage micro-TESE: a comparative cohort study. Int Urol Nephrol. 2019;51(3):401-408. https://doi.org/10.1007/s11255-019-02086-5. Talas H, Yaman O, Aydos K. Outcome of repeated micro-surgical testicular sperm extraction in patients with non-obstructive azoospermia. Asian J Androl. 2007;9(5):668-673. https://doi.org/10.1111/j.1745-7262.2007.00273.x. Donoso P, Tournaye H, Devroey P. Which is the best sperm retrieval technique for non-obstructive azoospermia? A systematic review. Hum Reprod Update. 2007;13(6):539-549. https://doi.org/10.1093/humupd/dmm029. Li H, Chen LP, Yang J, et al. Predictive value of FSH, testicular volume, and histopathological findings for the sperm retrieval rate of microdissection TESE in nonobstructive azoospermia: a meta-analysis. Asian J Androl. 2018;20(1):30-36. https://doi.org/10.4103/aja.aja_5_17. Boeri L, Bebi C, Dente D, et al. Outcomes and predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed classic TESE: results from a multicenter cross-sectional study. Int J Impot Res. 2022;34(8):795-799. https://doi.org/10.1038/s41443-021-00487-8. Corona G, Minhas S, Giwercman A, et al. Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(6):733-757. https://doi.org/10.1093/humupd/dmz028. Çayan S, Orhan İ, Altay B, et al. Fertility outcomes and predictors for successful sperm retrieval and pregnancy in 327 azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction. Andrology. 2021;9(1):253-259. https://doi.org/10.1111/andr.12910. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med. 2021;18(3):e1003583. https://doi.org/10.1371/journal.pmed.1003583. McLachlan RI, Rajpert-De Meyts E, Hoei-Hansen CE, de Kretser DM, Skakkebaek NE. Histological evaluation of the human testis - approaches to optimizing the clinical value of the assessment: mini review. Hum Reprod. 2007;22(1):2-16. https://doi.org/10.1093/humrep/del279. Caroppo E, Castiglioni F, Campagna C, et al. Intrasurgical parameters associated with successful sperm retrieval in patients with non-obstructive azoospermia undergoing salvage microdissection testicular sperm extraction. Andrology. 2021;9(6):1864-1871. https://doi.org/10.1111/andr.13082. Luo D, Wan X, Liu J, Tong T. Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res. 2018;27(6):1785-1805. https://doi.org/10.1177/0962280216669183. Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135. https://doi.org/10.1186/1471-2288-14-135. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603-605. https://doi.org/10.1007/s10654-010-9491-z. Muka T, Glisic M, Milic J, et al. A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. Eur J Epidemiol. 2020;35(1):49-60. https://doi.org/10.1007/s10654-019-00576-5. Wekker V, van Dammen L, Koning A, et al. Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis. Hum Reprod Update. 2020;26(6):942-960. https://doi.org/10.1093/humupd/dmaa029. Higgins JPT TJ, Chandler J, Cumpston M, et al. ed. Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane; 2022. Ghalayini IF, Alazab R, Halalsheh O, Al-Mohtaseb AH, Al-Ghazo MA. Repeated microdissection testicular sperm extraction in patients with non-obstructive azoospermia: Outcome and predictive factors. Arab J Urol. 2022;20(3):137-143. https://doi.org/10.1080/2090598x.2022.2028066. Çubuk A, Balaban M, Özkaptan O. Factors affecting outcomes of salvage micro testicular sperm extraction following a failed testicular sperm extraction. Haseki Tip Bulteni. 2020;58(3):281-285. https://doi.org/10.4274/haseki.galenos.2020.5642. Kalsi JS, Shah P, Thum Y, Muneer A, Ralph DJ, Minhas S. Salvage micro-dissection testicular sperm extraction; outcome in men with non-obstructive azoospermia with previous failed sperm retrievals. BJU Int. 2015;116(3):460-465. https://doi.org/10.1111/bju.12932. Ramasamy R, Schlegel PN. Microdissection testicular sperm extraction: effect of prior biopsy on success of sperm retrieval. J Urol. 2007;177(4):1447-1449. https://doi.org/10.1016/j.juro.2006.11.039. Ramasamy R, Ricci JA, Leung RA, Schlegel PN. Successful repeat microdissection testicular sperm extraction in men with nonobstructive azoospermia. J Urol. 2011;185(3):1027-1031. https://doi.org/10.1016/j.juro.2010.10.066. Ozman O, Tosun S, Bayazit N, Cengiz S, Bakircioglu ME. Efficacy of the second micro-testicular sperm extraction after failed first micro-testicular sperm extraction in men with nonobstructive azoospermia. Fertil Steril. 2021;115(4):915-921. https://doi.org/10.1016/j.fertnstert.2020.10.005. Tsujimura A, Miyagawa Y, Takao T, et al. Salvage microdissection testicular sperm extraction after failed conventional testicular sperm extraction in patients with nonobstructive azoospermia. J Urol. 2006;175(4):1446-1449. https://doi.org/10.1016/s0022-5347(05)00678-6. Xu T, Peng L, Lin X, Li J, Xu W. Predictors for successful sperm retrieval of salvage microdissection testicular sperm extraction (TESE) following failed TESE in nonobstructive azoospermia patients. Andrologia. 2017;49(4):e12642. https://doi.org/10.1111/and.12642. Major N, Edwards KR, Simpson K, Rogers M. An examination of predictive markers for successful sperm extraction procedures: a linear model and systematic review. Asian J Androl. 2023;25(1):38-42. https://doi.org/10.4103/aja202221. Ramasamy R, Lin K, Gosden LV, Rosenwaks Z, Palermo GD, Schlegel PN. High serum FSH levels in men with nonobstructive azoospermia does not affect success of microdissection testicular sperm extraction. Fertil Steril. 2009;92(2):590-593. https://doi.org/10.1016/j.fertnstert.2008.07.1703. Ntorkou A, Tsili AC, Goussia A, et al. Testicular apparent diffusion coefficient and magnetization transfer ratio: can these MRI parameters be used to predict successful sperm retrieval in nonobstructive azoospermia? AJR Am J Roentgenol. 2019;213(3):610-618. https://doi.org/10.2214/ajr.18.20816. Corona G, Pizzocaro A, Lanfranco F, et al. Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2017;23(3):265-275. https://doi.org/10.1093/humupd/dmx008. Boeri L, Palmisano F, Preto M, et al. Sperm retrieval rates in non-mosaic Klinefelter patients undergoing testicular sperm extraction: what expectations do we have in the real-life setting? Andrology. 2020;8(3):680-687. https://doi.org/10.1111/andr.12767. Zampieri N, Bosaro L, Costantini C, Zaffagnini S, Zampieri G. Relationship between testicular sperm extraction and varicocelectomy in patients with varicocele and nonobstructive azoospermia. Urology. 2013;82(1):74-77. https://doi.org/10.1016/j.urology.2013.03.037. Esteves SC, Miyaoka R, Roque M, Agarwal A. Outcome of varicocele repair in men with nonobstructive azoospermia: systematic review and meta-analysis. Asian J Androl. 2016;18(2):246-253. https://doi.org/10.4103/1008-682x.169562. Birowo P, Prasetyo DT, Pujianto DA, Atmoko W, Rasyid N, Sini IR. Effect of varicocele repair on sperm retrieval rate and testicular histopathological patterns in men with nonobstructive azoospermia. Asian J Androl. 2022;24(1):85-89. https://doi.org/10.4103/aja.aja_29_21. Minhas S, Bettocchi C, Boeri L, et al. European Association of Urology guidelines on male sexual and reproductive health: 2021 update on male infertility. Eur Urol. 2021;80(5):603-620. https://doi.org/10.1016/j.eururo.2021.08.014. |
معلومات مُعتمدة: | 82271672 National Natural Science Foundation of China; 82071697 National Natural Science Foundation of China; 81871200 National Natural Science Foundation of China; 2022BCA042 Key Research and Development Program of Hubei Province; 2020CXB051 Medical Innovation Project of Fujian Province |
فهرسة مساهمة: | Keywords: meta-analysis; non-obstructive azoospermia; salvage microdissection testicular sperm extraction; testicular sperm retrieval |
المشرفين على المادة: | 9002-68-0 (Follicle Stimulating Hormone) 9002-67-9 (Luteinizing Hormone) 0 (Follicle Stimulating Hormone, Human) |
تواريخ الأحداث: | Date Created: 20230512 Date Completed: 20231221 Latest Revision: 20231221 |
رمز التحديث: | 20231221 |
DOI: | 10.1111/andr.13448 |
PMID: | 37172416 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2047-2927 |
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DOI: | 10.1111/andr.13448 |