دورية أكاديمية
أعرض في EDS

Resection of Skin Cancer Resulting in Free Vascularized Tissue Reconstruction: Always a Therapeutic Failure?

التفاصيل البيبلوغرافية
العنوان: Resection of Skin Cancer Resulting in Free Vascularized Tissue Reconstruction: Always a Therapeutic Failure?
المؤلفون: Rauchenwald T; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Tyrol, Austria., Augustin A; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Tyrol, Austria., Steinbichler TB; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Tyrol, Austria., Zelger BW; Private Praxis for Dermatopathology Innsbruck & Zams, 6020 Innsbruck, Tyrol, Austria., Pierer G; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Tyrol, Austria., Schmuth M; Department of Dermatology, Venerology and Allergology, Medical University of Innsbruck, 6020 Innsbruck, Tyrol, Austria., Wolfram D; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Tyrol, Austria., Morandi EM; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Tyrol, Austria.
المصدر: Cancers [Cancers (Basel)] 2023 Apr 25; Vol. 15 (9). Date of Electronic Publication: 2023 Apr 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The globally increasing incidence of cutaneous malignancies leads, in parallel, to increasing numbers of locally advanced skin cancer resulting in reconstructive surgery. Reasons for locally advanced skin cancer may be a patient's neglect or aggressive tumor growth, such as desmoplastic growth or perineural invasion. This study investigates characteristics of cutaneous malignancies requiring microsurgical reconstruction with the aim of identifying possible pitfalls and improving diagnostic and therapeutic processes. A retrospective data analysis from 2015 to 2020 was conducted. Seventeen patients ( n = 17) were included. The mean age at reconstructive surgery was 68.5 (±13) years. The majority of patients (14/17, 82%) presented with recurrent skin cancer. The most common histological entity was squamous cell carcinoma (10/17, 59%). All neoplasms showed at least one of the following histopathological characteristics: desmoplastic growth (12/17, 71%), perineural invasion (6/17, 35%), or tumor thickness of at least 6 mm (9/17, 53%). The mean number of surgical resections until cancer-free resection margins (R0) were achieved was 2.4 (±0.7). The local recurrence rate and the rate of distant metastases were 36%. Identified high-risk neoplastic characteristics, such as desmoplastic growth, perineural invasion, and a tumor depth of at least 6 mm, require a more extensive surgical treatment without concerns about defect size.
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فهرسة مساهمة: Keywords: basal cell carcinoma; cutaneous squamous cell carcinoma; dermatologic surgery; desmoplastic; free-flap reconstruction; melanoma; perineural invasion; reconstructive surgery; skin cancer
تواريخ الأحداث: Date Created: 20230513 Latest Revision: 20230515
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10177333
DOI: 10.3390/cancers15092464
PMID: 37173928
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6694
DOI:10.3390/cancers15092464