دورية أكاديمية
Biomarkers of collagen turnover and wound healing in chronic thromboembolic pulmonary hypertension patients before and after pulmonary endarterectomy.
| العنوان: | Biomarkers of collagen turnover and wound healing in chronic thromboembolic pulmonary hypertension patients before and after pulmonary endarterectomy. |
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| المؤلفون: | Andersen S; Department of Cardiology, Aarhus University Hospital, Denmark. Electronic address: stineandersen@clin.au.dk., Reese-Petersen AL; Nordic Bioscience, Denmark., Braams N; Department of Pulmonology, Amsterdam University Medical Center, the Netherlands., Andersen MJ; Department of Cardiology, Aarhus University Hospital, Denmark., Mellemkjær S; Department of Cardiology, Aarhus University Hospital, Denmark., Andersen A; Department of Cardiology, Aarhus University Hospital, Denmark., Bogaard HJ; Department of Pulmonology, Amsterdam University Medical Center, the Netherlands., Genovese F; Nordic Bioscience, Denmark., Nielsen-Kudsk JE; Department of Cardiology, Aarhus University Hospital, Denmark. |
| المصدر: | International journal of cardiology [Int J Cardiol] 2023 Aug 01; Vol. 384, pp. 82-88. Date of Electronic Publication: 2023 May 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981- |
| مواضيع طبية MeSH: | Hypertension, Pulmonary*/diagnosis , Hypertension, Pulmonary*/etiology , Hypertension, Pulmonary*/surgery , Pulmonary Embolism*/complications , Pulmonary Embolism*/diagnosis , Pulmonary Embolism*/surgery, Humans ; Chronic Disease ; Endarterectomy/methods ; Collagen ; Wound Healing ; Biomarkers ; Pulmonary Artery/surgery |
| مستخلص: | Background: In chronic thromboembolic pulmonary hypertension (CTEPH), fibrotic remodeling of tissue and thrombi contributes to disease progression. Removal of the thromboembolic mass by pulmonary endarterectomy (PEA) improves hemodynamics and right ventricular function, but the roles of different collagens before as well as after PEA are not well understood. Methods: In this study, hemodynamics and 15 different biomarkers of collagen turnover and wound healing were evaluated in 40 CTEPH patients at diagnosis (baseline) and 6 and 18 months after PEA. Baseline biomarker levels were compared with a historical cohort of 40 healthy subjects. Results: Biomarkers of collagen turnover and wound healing were increased in CTEPH patients compared with healthy controls, including a 35-fold increase in the PRO-C4 marker of type IV collagen formation and a 55-fold increase in the C3M marker of type III collagen degradation. PEA reduced pulmonary pressures to almost normal levels 6 months after the procedure, with no further improvement at 18 months. There were no changes in any of the measured biomarkers after PEA. Conclusions: Biomarkers of collagen formation and degradation are increased in CTEPH suggesting a high collagen turnover. While PEA effectively reduces pulmonary pressures, collagen turnover is not significantly modified by surgical PEA. Competing Interests: Declaration of Competing Interest ALRP and FG are employed by Nordic Bioscience, Biomarkers and Research. None of the authors from Nordic Bioscience received any kind of financial benefits or other bonuses for the work described in this manuscript. (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| التعليقات: | Comment in: Int J Cardiol. 2023 Dec 1;392:131304. (PMID: 37652276) |
| فهرسة مساهمة: | Keywords: Biomarkers; Chronic thromboembolic pulmonary hypertension; Collagen; Right heart failure |
| المشرفين على المادة: | 9007-34-5 (Collagen) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230513 Date Completed: 20230609 Latest Revision: 20231109 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijcard.2023.05.016 |
| PMID: | 37178803 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1874-1754 |
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| DOI: | 10.1016/j.ijcard.2023.05.016 |