دورية أكاديمية
A comparison of prophylactic antiemetic therapy with palonosetron and dexamethasone as single-agents or in combination in adult patients undergoing laparoscopic surgery: A randomized trial.
| العنوان: | A comparison of prophylactic antiemetic therapy with palonosetron and dexamethasone as single-agents or in combination in adult patients undergoing laparoscopic surgery: A randomized trial. |
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| المؤلفون: | Sadhoo N; Department of Anaesthesiology, Sakra World Hospital, Bengaluru, Karnataka, India., Prakash J; Department of Critical Care Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Kumar V; Department of Trauma Anaesthesia, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Kharwar RK; Department of Intensive Care Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Ahmad S; Department of Anaesthesia, Batra Hospital and Medical Research Centre, New Delhi, India., Sethi BK; Department of Surgery, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. |
| المصدر: | International journal of critical illness and injury science [Int J Crit Illn Inj Sci] 2023 Jan-Mar; Vol. 13 (1), pp. 4-10. Date of Electronic Publication: 2023 Mar 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications & Media Pvt. Ltd Country of Publication: India NLM ID: 101571136 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2229-5151 (Print) Linking ISSN: 22295151 NLM ISO Abbreviation: Int J Crit Illn Inj Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Mumbai : Medknow Publications & Media Pvt. Ltd., [2011]- |
| مستخلص: | Background: The incidence of postoperative nausea and vomiting (PONV) is quite high after laparoscopic surgeries. This study endeavors to compare the efficacy of the combination of palonosetron and dexamethasone with that of either drug alone in the prevention of PONV in patients undergoing laparoscopic surgeries. Methods: This randomized, parallel-group trial was done on ninety adults of American Society of Anesthesiologists Grade I and II patients aged 18-60 years undergoing laparoscopic surgeries under general anesthesia. The patients were randomly divided into three groups of thirty patients each. Group P ( n = 30) received palonosetron 0.075 mg intravenously (iv), Group D ( n = 30) received dexamethasone 8 mg iv and Group P + D ( n = 30) received palonosetron 0.075 mg and dexamethasone 8 mg iv. The primary outcome was incidence of PONV in 24 h, and the secondary outcome was a number of rescue antiemetics required. To compare the proportions in the groups, unpaired t -test, Mann-Whitney U -test, Chi-square test, or Fisher's exact test was applied. Results: We found that the overall incidence of PONV was 46.7% in Group P, 50% in Group D, and 43.3% in Group P + D during the first 24 h. Rescue antiemetic was required in 27% of the patients in Group P and Group D compared to 23% of the patients in Group P + D and twice in 3% of the patients in Group P, 7% of the patients in Group D, and none in Group P + D which were not significant. Conclusions: The combination therapy of palonosetron plus dexamethasone did not significantly reduce the incidence of PONV when compared with either drug alone. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 International Journal of Critical Illness and Injury Science.) |
| فهرسة مساهمة: | Keywords: Dexamethasone; laparoscopic surgery; palonosetron; postoperative nausea and vomiting |
| تواريخ الأحداث: | Date Created: 20230514 Latest Revision: 20231031 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10167812 |
| DOI: | 10.4103/ijciis.ijciis_150_20 |
| PMID: | 37180300 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2229-5151 |
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| DOI: | 10.4103/ijciis.ijciis_150_20 |