دورية أكاديمية
Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders.
| العنوان: | Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders. |
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| المؤلفون: | Emilie Munk D; Department of Hepatology and Gastroenterology, Aarhus University Hospital; dittmu@rm.dk., Teicher Kirk F; Department of Hepatology and Gastroenterology, Aarhus University Hospital., Vendelbo M; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital., Vase K; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital., Munk O; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital., Ott P; Department of Hepatology and Gastroenterology, Aarhus University Hospital., Damgaard Sandahl T; Department of Hepatology and Gastroenterology, Aarhus University Hospital. |
| المصدر: | Journal of visualized experiments : JoVE [J Vis Exp] 2023 Apr 28 (194). Date of Electronic Publication: 2023 Apr 28. |
| نوع المنشور: | Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Boston, Mass. : MYJoVE Corporation, 2006]- |
| مواضيع طبية MeSH: | Copper*/metabolism , Hepatolenticular Degeneration*/metabolism, Animals ; Humans ; Positron Emission Tomography Computed Tomography ; Tissue Distribution ; Positron-Emission Tomography/methods ; Copper Radioisotopes |
| مستخلص: | Copper is an essential trace element, functioning in catalysis and signaling in biological systems. Radiolabeled copper has been used for decades in studying basic human and animal copper metabolism and copper-related disorders, such as Wilson disease (WD) and Menke's disease. A recent addition to this toolkit is 64-copper ( 64 Cu) positron emission tomography (PET), combining the accurate anatomical imaging of modern computed tomography (CT) or magnetic resonance imaging (MRI) scanners with the biodistribution of the 64 Cu PET tracer signal. This allows the in vivo tracking of copper fluxes and kinetics, thereby directly visualizing human and animal copper organ traffic and metabolism. Consequently, 64 Cu PET is well-suited for evaluating clinical and preclinical treatment effects and has already demonstrated the ability to diagnose WD accurately. Furthermore, 64 Cu PET/CT studies have proven valuable in other scientific areas like cancer and stroke research. The present article shows how to perform 64 Cu PET/CT or PET/MR in humans. Procedures for 64 Cu handling, patient preparation, and scanner setup are demonstrated here. |
| المشرفين على المادة: | 789U1901C5 (Copper) 0 (Copper-64) 0 (Copper Radioisotopes) |
| تواريخ الأحداث: | Date Created: 20230515 Date Completed: 20230517 Latest Revision: 20230525 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3791/65109 |
| PMID: | 37184248 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-087X |
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| DOI: | 10.3791/65109 |