دورية أكاديمية
Valproate-induced murine autism spectrum disorder is associated with dysfunction of amygdala parvalbumin interneurons and downregulation of AMPK/SIRT1/PGC1α signaling.
| العنوان: | Valproate-induced murine autism spectrum disorder is associated with dysfunction of amygdala parvalbumin interneurons and downregulation of AMPK/SIRT1/PGC1α signaling. |
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| المؤلفون: | Zahedi E; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Sadr SS; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. sadrshah@sina.tums.ac.ir.; Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. sadrshah@sina.tums.ac.ir., Sanaeierad A; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Roghani M; Neurophysiology Research Center, Shahed University, Tehran, Iran. mroghani@shahed.ac.ir. |
| المصدر: | Metabolic brain disease [Metab Brain Dis] 2023 Aug; Vol. 38 (6), pp. 2093-2103. Date of Electronic Publication: 2023 May 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Springer Original Publication: New York : Plenum, c1986- |
| مواضيع طبية MeSH: | Autism Spectrum Disorder*/chemically induced , Autism Spectrum Disorder*/metabolism , Prenatal Exposure Delayed Effects*/metabolism, Animals ; Female ; Mice ; Pregnancy ; Rats ; AMP-Activated Protein Kinases/metabolism ; Amygdala ; Behavior, Animal ; Caspase 3/metabolism ; Disease Models, Animal ; Down-Regulation ; Interneurons/metabolism ; Parvalbumins/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Reactive Oxygen Species/metabolism ; Sirtuin 1/metabolism ; Valproic Acid/adverse effects |
| مستخلص: | Autism spectrum disorder (ASD) is a neurodevelopmental condition that is characterized by difficulty in social behavior and restricted behaviors. Also, in ASD, several accompanying disorders such as anxiety are observed. Considering the important role of amygdala in the pathophysiology of ASD, the present study focused on the neuronal changes and it possible signaling pathway in amygdala. After prenatal exposure to valproate (VPA; 600 mg/kg, i.p, on embryonic day 12.5), amount of ROS, MMP, caspase-3 activity, AMPK, SIRT1 and PGC1α proteins, and parvalbumin interneurons in the amygdala were assessed following evaluation of ASD and anxiety-like behaviors. Amygdala analysis revealed ROS accumulation and decreased MMP in autistic rats. In addition, caspase-3 activation elevated and immunoreactivity for parvalbumin interneurons decreased. These were accompanied by anxiety and autistic-like behaviors in open field test, elevated zero maze and U-Shaped 2 Choice Field maze. Also, our data showed that in the valproate group, protein levels of AMPK, SIRT1 and PGC1α reduced. Collectively, our results indicate that prenatal exposure to valproate leads to anxiety and autistic-like behaviors, partly through its targeting amygdala parvalbumin interneurons dysfunction and this might be affected by disturbed AMPK/SIRT1/PGC1α signaling pathway. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Amygdala; Autism spectrum disorder; Mitochondrial dysfunction; Oxidative stress; Valproate |
| المشرفين على المادة: | EC 2.7.11.31 (AMP-Activated Protein Kinases) EC 3.4.22.- (Caspase 3) 0 (Parvalbumins) 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha) 0 (Reactive Oxygen Species) EC 3.5.1.- (SIRT1 protein, human) EC 3.5.1.- (Sirtuin 1) 614OI1Z5WI (Valproic Acid) |
| تواريخ الأحداث: | Date Created: 20230515 Date Completed: 20230911 Latest Revision: 20231121 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s11011-023-01227-1 |
| PMID: | 37184727 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-7365 |
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| DOI: | 10.1007/s11011-023-01227-1 |