دورية أكاديمية
أعرض في EDS

Changes in Prediabetes Status Among Adults During a 6-Month Randomized Placebo-controlled Supplement Trial With Nutrition and Lifestyle Counselling and 6-Month Follow-up.

التفاصيل البيبلوغرافية
العنوان: Changes in Prediabetes Status Among Adults During a 6-Month Randomized Placebo-controlled Supplement Trial With Nutrition and Lifestyle Counselling and 6-Month Follow-up.
المؤلفون: Bessell E; The Boden Initiative, University of Sydney, Charles Perkins Centre, Sydney, New South Wales, Australia. Electronic address: erica.bessell@sydney.edu.au., Markovic TP; The Boden Initiative, University of Sydney, Charles Perkins Centre, Sydney, New South Wales, Australia; Metabolism and Obesity Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia., Caterson ID; The Boden Initiative, University of Sydney, Charles Perkins Centre, Sydney, New South Wales, Australia; Metabolism and Obesity Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia., Fuller NR; The Boden Initiative, University of Sydney, Charles Perkins Centre, Sydney, New South Wales, Australia.
المصدر: Canadian journal of diabetes [Can J Diabetes] 2023 Oct; Vol. 47 (7), pp. 571-578. Date of Electronic Publication: 2023 May 13.
نوع المنشور: Randomized Controlled Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Canadian Diabetes Association Country of Publication: Canada NLM ID: 101148810 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3840 (Electronic) Linking ISSN: 14992671 NLM ISO Abbreviation: Can J Diabetes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Toronto : Canadian Diabetes Association, 2002-
مواضيع طبية MeSH: Prediabetic State*/epidemiology , Prediabetic State*/therapy, Adult ; Humans ; Male ; Glycated Hemoglobin ; Follow-Up Studies ; Blood Glucose ; Dietary Supplements ; Life Style ; Counseling
مستخلص: Objectives: In this work, we present an exploratory within-trial analysis of the changing prevalence of prediabetes in response to nutrition and lifestyle counselling provided as part of a randomized placebo-controlled supplement trial with follow-up. We aimed to identify factors associated with changing glycemia status.
Methods: Participants (n=401) in this clinical trial were adults with a body mass index (BMI) of ≥25 kg/m 2 and prediabetes (defined by the American Diabetes Association as a fasting plasma glucose [FPG] of 5.6 to 6.9 mmol/L or a glycated hemoglobin [A1C] of 5.7% to 6.4%) within 6 months before trial entry. The trial consisted of a 6-month randomized intervention with 2 dietary supplements and/or placebo. At the same time, all participants received nutrition and lifestyle counselling. This was followed by a 6-month follow-up. Glycemia status was assessed at baseline and at 6 and 12 months.
Results: At baseline, 226 participants (56%) met a threshold for prediabetes, including 167 (42%) with elevated FPG and 155 (39%) with elevated A1C. After the 6-month intervention, the prevalence of prediabetes decreased to 46%, driven by a reduction in prevalence of elevated FPG to 29%. The prevalence of prediabetes then increased to 51% after follow-up. Risk of prediabetes was associated with older age (odds ratio [OR], 1.05; p<0.01), BMI (OR, 1.06; p<0.05), and male sex (OR, 1.81; p=0.01). Participants who reverted to normoglycemia had greater weight loss and lower baseline glycemia.
Conclusions: Glycemia status can fluctuate over time and improvements can be gained from lifestyle interventions, with certain factors associated with a higher likelihood of reverting to normoglycemia.
(Copyright © 2023 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: A1C; HbA1c; clinical trial; essai clinique; fasting plasma glucose; glycémie veineuse à jeun; interventions axées sur le mode de vie; lifestyle intervention; normoglycemia; normoglycémie; prediabetes; prédiabète
المشرفين على المادة: 0 (Glycated Hemoglobin)
0 (Blood Glucose)
تواريخ الأحداث: Date Created: 20230515 Date Completed: 20231013 Latest Revision: 20231018
رمز التحديث: 20240628
DOI: 10.1016/j.jcjd.2023.05.004
PMID: 37187439
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-3840
DOI:10.1016/j.jcjd.2023.05.004