دورية أكاديمية
أعرض في EDS

Differential gene expression in peripheral leukocytes of pre-weaned Holstein heifer calves with respiratory disease.

التفاصيل البيبلوغرافية
العنوان: Differential gene expression in peripheral leukocytes of pre-weaned Holstein heifer calves with respiratory disease.
المؤلفون: Elder LA; Department of Veterinary Clinical Sciences, Field Disease Investigation Unit, Washington State University, Pullman, Washington, United States of America., Hinnant HR; Department of Veterinary Clinical Sciences, Field Disease Investigation Unit, Washington State University, Pullman, Washington, United States of America., Mandella CM; Department of Veterinary Clinical Sciences, Field Disease Investigation Unit, Washington State University, Pullman, Washington, United States of America., Claus-Walker RA; Department of Veterinary Clinical Sciences, Field Disease Investigation Unit, Washington State University, Pullman, Washington, United States of America., Parrish LM; Department of Veterinary Clinical Sciences, Field Disease Investigation Unit, Washington State University, Pullman, Washington, United States of America., Slanzon GS; Department of Veterinary Clinical Sciences, Field Disease Investigation Unit, Washington State University, Pullman, Washington, United States of America., McConnel CS; Department of Veterinary Clinical Sciences, Field Disease Investigation Unit, Washington State University, Pullman, Washington, United States of America.
المصدر: PloS one [PLoS One] 2023 May 16; Vol. 18 (5), pp. e0285876. Date of Electronic Publication: 2023 May 16 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Cattle Diseases*/epidemiology , Respiratory Tract Diseases*/epidemiology , Respiration Disorders*, Animals ; Cattle ; Female ; Longitudinal Studies ; Weaning ; Dairying ; Gene Expression
مستخلص: Bovine respiratory disease (BRD) is a leading cause of calf morbidity and mortality, and prevalence remains high despite current management practices. Differential gene expression (DGE) provides detailed insight into individual immune responses and can illuminate enriched pathways and biomarkers that contribute to disease susceptibility and outcomes. The aims of this study were to investigate differences in peripheral leukocyte gene expression in Holstein preweaned heifer calves 1) with and without BRD, and 2) across weeks of age. Calves were enrolled for this short-term longitudinal study on two commercial dairies in Washington State. Calves were assessed every two weeks throughout the pre-weaning period using clinical respiratory scoring (CRS) and thoracic ultrasonography (TUS), and blood samples were collected. Calves were selected that were either healthy (n = 10) or had BRD diagnosed by CRS (n = 7), TUS (n = 6), or both (n = 6) in weeks 5 or 7 of life). Three consecutive time point samples were analyzed for each BRD calf consisting of PRE, ONSET, and POST samples. Nineteen genes of interest were selected based on previous gene expression studies in cattle: ALOX15, BPI, CATHL6, CXCL8, DHX58, GZMB, HPGD, IFNG, IL17D, IL1R2, ISG15, LCN2, LIF, MX1, OAS2, PGLYRP1, S100A8, SELP, and TNF. Comparisons were made between age and disease time point matched BRD and healthy calves as well as between calf weeks of age. No DGE was observed between diseased and healthy calves; however, DGE was observed between calf weeks of age regardless of disease state. Developmental differences in leukocyte gene expression, phenotype, and functionality make pre-weaned calves immunologically distinct from mature cattle, and early life shifts in calf leukocyte populations likely contribute to the age-related gene expression differences we observed. Age overshadows disease impacts to influence gene expression in young calves, and immune development progresses upon a common trajectory regardless of disease during the preweaning period.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Elder et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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تواريخ الأحداث: Date Created: 20230516 Date Completed: 20230518 Latest Revision: 20230615
رمز التحديث: 20230615
مُعرف محوري في PubMed: PMC10187941
DOI: 10.1371/journal.pone.0285876
PMID: 37192182
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0285876