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Negative Regulation of Innate Immune Signaling by Components of the Button Mushroom Agaricus bisporus.

التفاصيل البيبلوغرافية
العنوان: Negative Regulation of Innate Immune Signaling by Components of the Button Mushroom Agaricus bisporus.
المؤلفون: O'Sullivan M; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., Dempsey E; School of Genetics & Microbiology, Trinity College, Dublin 2, D02 PN40, Ireland., Case S; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., Hackett EE; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., Ledwith AE; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., Prendeville H; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., O'Brien T; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., Lewis F; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., Murphy DM; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland., Yadav S; MBio, Monaghan Mushrooms, Tyholland, Co. Monaghan, Monaghan, H18 FW95, Ireland., Wilson J; MBio, Monaghan Mushrooms, Tyholland, Co. Monaghan, Monaghan, H18 FW95, Ireland., Corr SC; School of Genetics & Microbiology, Trinity College, Dublin 2, D02 PN40, Ireland., Sheedy FJ; School of Biochemistry & Immunology, Trinity College, Dublin 2, D02 R590, Ireland.
المصدر: Molecular nutrition & food research [Mol Nutr Food Res] 2023 Jul; Vol. 67 (14), pp. e2200845. Date of Electronic Publication: 2023 Jun 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2004-
مواضيع طبية MeSH: Agaricus*, Humans ; Ligands ; Powders ; Immunity, Innate
مستخلص: Scope: Mushrooms are valued as an edible and medical resource for millennia. As macrofungi, they possess conserved molecular components recognized by innate immune cells like macrophages, yet unlike pathogenic fungi, they do not trigger the immune system in the same way. That these well-tolerated foods both avoid immuno-surveillance and have positive health benefits, highlights the dearth of information on the interactions of mushroom-derived products with the immune system.
Methods and Results: Using powders produced from the common white button mushroom, Agaricus bisporus, it is observed that pre-treatment of mouse and human macrophages with mushroom powders attenuates innate immune signaling triggered by microbial ligands like LPS and  β-glucans, including NFκB activation and pro-inflammatory cytokine production. This effect of mushroom powders is observed at lower doses of TLR ligands, suggesting a model of competitive inhibition whereby mushroom compounds bind and occupy innate immune receptors, precluding activation by microbial stimuli. This effect is preserved following simulated digestion of the powders. Moreover, in vivo delivery of mushroom powders attenuates the development of colitis in a DSS-mouse model.
Conclusion: This data highlights an important anti-inflammatory role for powdered A. bisporus mushrooms, which can be further utilized to develop complementary approaches to modulate chronic inflammation and disease.
(© 2023 The Authors. Macromolecular Symposia published by Wiley-VCH GmbH.)
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فهرسة مساهمة: Keywords: Dectin-1; inflammation; macrophages; mushrooms;  β-glucan
المشرفين على المادة: 0 (Ligands)
0 (Powders)
SCR Organism: Agaricus bisporus
تواريخ الأحداث: Date Created: 20230517 Date Completed: 20230724 Latest Revision: 20230725
رمز التحديث: 20240628
DOI: 10.1002/mnfr.202200845
PMID: 37195234
قاعدة البيانات: MEDLINE
الوصف
تدمد:1613-4133
DOI:10.1002/mnfr.202200845