دورية أكاديمية
The accuracy of cystoscopy in predicting muscle invasion in newly diagnosed bladder cancer patients.
| العنوان: | The accuracy of cystoscopy in predicting muscle invasion in newly diagnosed bladder cancer patients. |
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| المؤلفون: | van Straten CGJI; Department for Health Evidence, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., Bruins MH; Department of Urology, Zuyderland Medisch Centrum, Heerlen and Sittard, The Netherlands., Dijkstra S; Department of Urology, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands., Cornel EB; Department of Urology, Ziekenhuisgroep Twente, Hengelo, The Netherlands., Kortleve MDH; Department of Urology, Ziekenhuis Gelderse Vallei, Ede, The Netherlands., de Vocht TF; Department of Urology, Ziekenhuis Bernhoven, Uden, The Netherlands., Kiemeney LALM; Department for Health Evidence, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. bart.kiemeney@radboudumc.nl.; Department of Urology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. bart.kiemeney@radboudumc.nl., van der Heijden AG; Department of Urology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. |
| المصدر: | World journal of urology [World J Urol] 2023 Jul; Vol. 41 (7), pp. 1829-1835. Date of Electronic Publication: 2023 May 17. |
| نوع المنشور: | Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8307716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-8726 (Electronic) Linking ISSN: 07244983 NLM ISO Abbreviation: World J Urol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Berlin ; New York] : Springer International, 1983- |
| مواضيع طبية MeSH: | Cystoscopy*/methods , Urinary Bladder Neoplasms*/diagnosis , Urinary Bladder Neoplasms*/surgery , Urinary Bladder Neoplasms*/pathology, Humans ; Prospective Studies ; Predictive Value of Tests ; Urinary Bladder/pathology |
| مستخلص: | Purpose: The prognosis of muscle-invasive bladder cancer (MIBC) has not improved for three decades. Transurethral resection of the bladder tumor (TURBT) is the standard procedure for local tumor staging. TURBT has several limitations, including the spread of tumor cells. Therefore, an alternative is needed in patients with suspected MIBC. Recent studies have shown that mpMRI is very accurate in staging bladder tumors. Because the diagnostic efficacy of urethrocystoscopy (UCS) has been reported as good as the efficacy of mpMRI to predict muscle invasion we performed this prospective multicenter study in which we compare UCS with pathology. Methods: From July 2020 until March 2022, 321 patients with suspected primary BC in seven participating Dutch hospitals were included in this study. A flexible UCS was performed by urologists, physician assistants, or residents. Predictions of muscle invasion using a 5-point Likert scale alongside the histopathology data were recorded. The sensitivity, specificity, predictive values, and 95% confidence intervals were determined using a standard contingency table. Results: Of the 321 included patients, 232 (72.3%) received a histopathological diagnosis of non-muscle-invasive bladder cancer (NMIBC) and 71 (22.1%) were histopathologically diagnosed as MIBC. In 2 patients (0.6%), classification was not possible (Tx). Cystoscopy predicted muscle invasion with a sensitivity of 71.8% (95% CI 59.9-81.9), and a specificity of 89.9% (95% CI 85.4-93.3). This corresponds to a positive predictive value (PPV) of 67.1% and a negative predictive value (NPV) of 91.7%. Conclusion: Our study shows a moderate accuracy of cystoscopy to predict muscle invasion. This result does not support the use of cystoscopy only instead of TURBT for local staging. (© 2023. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Accuracy; Bladder cancer; Cystoscopy; Muscle invasion; Staging |
| تواريخ الأحداث: | Date Created: 20230517 Date Completed: 20230719 Latest Revision: 20231222 |
| رمز التحديث: | 20231222 |
| مُعرف محوري في PubMed: | PMC10352162 |
| DOI: | 10.1007/s00345-023-04428-6 |
| PMID: | 37195314 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1433-8726 |
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| DOI: | 10.1007/s00345-023-04428-6 |