دورية أكاديمية
Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh.
| العنوان: | Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh. |
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| المؤلفون: | Ashraf T; Laboratory of Infection Biology, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh., Sarker PK; Laboratory of Biochemistry, Dinajpur Diabetic Hospital, Dinajpur, Bangladesh., Hosen MI; Laboratory of Clinical Biochemistry and Translational Medicine, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh., Rahman A; Laboratory of Infection Biology, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh., Hasan AKMM; Laboratory of Infection Biology, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh., Rahman T; Laboratory of Infection Biology, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh. |
| المصدر: | Journal of parasitology research [J Parasitol Res] 2023 May 08; Vol. 2023, pp. 3885160. Date of Electronic Publication: 2023 May 08 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101526294 Publication Model: eCollection Cited Medium: Print ISSN: 2090-0023 (Print) Linking ISSN: 20900023 NLM ISO Abbreviation: J Parasitol Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Hindawi Pub. Corp., 2009- |
| مستخلص: | Toxoplasma gondii is an intracellular protozoan parasite that causes toxoplasmosis in around one-third of the world population, particularly in pregnant women and immunocompromised individuals. Diabetes mellitus (DM) is one of the most severe global health challenges in the 21st century, and especially, type-2 diabetes mellitus (T2DM) accounts for 90% of the diabetes cases diagnosed globally. In Bangladesh, the rate of T2DM is rising gradually with the improvement in living standards. The aim of this study is to find out the correlation between latent toxoplasmosis and T2DM, emphasizing the pro-inflammatory cytokine immunity. For this, 100 ( N = 100) patients with T2DM and 100 ( N = 100) healthy controls were enrolled to determine the seroprevalence of toxoplasmosis using enzyme-linked immunosorbent assay (ELISA). In addition, ELISA was also performed to determine the level of pro-inflammatory cytokine, interleukin (IL)-12, to understand its role in the development of toxoplasmosis. In our study, 39.39% of the T2DM patients were positive with anti- T. gondii Immunoglobulin G by ELISA, whereas the rate of seropositivity in healthy controls was 39.73%. We did not find significant association between T. gondii infection and T2DM, but our data confirmed a high prevalence of chronic toxoplasmosis in Bangladeshi population. From hematology tests, it was found that the T2DM patients had significantly lower levels of total white blood cells ( P = 0.0015), circulating eosinophils ( P = 0.0026), and neutrophils ( P = 0.0128) than the healthy controls. On the other hand, the levels of lymphocytes ( P = 0.0204) and monocytes ( P = 0.0067) were significantly higher in patients. Furthermore, T. gondii infected T2DM patients had significantly higher levels of IL-12 than the healthy controls ( P = 0.026), suggesting a link between parasitic infection and IL-12 secretion. Further studies are to be performed to find out the exact cause of high prevalence of chronic T. gondii infection in Bangladeshi population. Competing Interests: The authors declare that they have no conflicts of interest. (Copyright © 2023 Tamanna Ashraf et al.) |
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| تواريخ الأحداث: | Date Created: 20230517 Latest Revision: 20230519 |
| رمز التحديث: | 20230519 |
| مُعرف محوري في PubMed: | PMC10185420 |
| DOI: | 10.1155/2023/3885160 |
| PMID: | 37197738 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2090-0023 |
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| DOI: | 10.1155/2023/3885160 |