دورية أكاديمية
The association between metabolic dysfunction-associated fatty liver disease and chronic kidney disease: A systematic review and meta-analysis.
| العنوان: | The association between metabolic dysfunction-associated fatty liver disease and chronic kidney disease: A systematic review and meta-analysis. |
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| المؤلفون: | Agustanti N; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital, Bandung, Indonesia. Electronic address: nenny_agustanti@yahoo.com., Soetedjo NNM; Division of Endocrine and Metabolism, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital, Bandung, Indonesia. Electronic address: nsoetedjo0@gmail.com., Damara FA; Department of Surgery, Yale School of Medicine, New Haven, United States; Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital, Bandung, Indonesia. Electronic address: fachreza.damara@yale.edu., Iryaningrum MR; Department of Internal Medicine, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. Electronic address: maria.riastuti@atmajaya.ac.id., Permana H; Division of Endocrine and Metabolism, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital, Bandung, Indonesia. Electronic address: hikmat.permana@unpad.ac.id., Bestari MB; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital, Bandung, Indonesia. Electronic address: begawanb@yahoo.com., Supriyadi R; Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital, Bandung, Indonesia. Electronic address: rudisdoc@gmail.com. |
| المصدر: | Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2023 May; Vol. 17 (5), pp. 102780. Date of Electronic Publication: 2023 May 13. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101462250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0334 (Electronic) Linking ISSN: 18714021 NLM ISO Abbreviation: Diabetes Metab Syndr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Ltd. |
| مواضيع طبية MeSH: | Non-alcoholic Fatty Liver Disease*/complications , Non-alcoholic Fatty Liver Disease*/diagnosis , Non-alcoholic Fatty Liver Disease*/epidemiology , Renal Insufficiency, Chronic*/epidemiology , Renal Insufficiency, Chronic*/etiology, Humans ; Cross-Sectional Studies ; Databases, Factual ; Liver Cirrhosis |
| مستخلص: | Background and Aims: The term metabolic dysfunction-associated fatty liver disease (MAFLD) has been established to better define patients with fatty liver disease who also present with metabolic dysfunction. However, the association between MAFLD and chronic-kidney disease (CKD) remains elusive. Methods: . We conducted systematic literature searching across multiple databases-PubMed, EMBASE, Cochrane library, and Google Scholar up until June 9th, 2022. The main exposure was the diagnosis of MAFLD and nonalcoholic fatty liver disease (NAFLD) regardless of the diagnostic modalities being used. The outcome of interest was the prevalence or the incidence of CKD. Results: There were 355,886 subjects from 11 included studies with the period of follow up of 4.6-6.5 years. Meta-analysis of cross-sectional studies showed that MAFLD was associated with a higher prevalent CKD (OR 1.50, 95%CI [1.02-2.23]; test for overall effect Z = 2.04, p = 0.04; I 2 = 97.7%, p < 0.001) and incident CKD (adjusted HR 1.35, 95%CI [1.18-1.52]; test for overall effect Z = 15.47, p < 0.001; I 2 = 84.6%, p < 0.001) and did not vary between age, sex, comorbidities, study region, and follow-up duration. No difference in CKD prevalence was found between MAFLD and NAFLD patients. Significant liver fibrosis, but not steatosis in was associated with greater odds of developing CKD. More severe MAFLD was also associated with higher odds of developing CKD. Conclusion: This present meta-analysis using a large population indicates a significant association between MAFLD and the prevalence and incidence of CKD. Competing Interests: Declaration of competing interest The authors declare there was no competing interest in this study. (Copyright © 2023 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chronic kidney disease; MAFLD; NAFLD |
| تواريخ الأحداث: | Date Created: 20230518 Date Completed: 20230619 Latest Revision: 20230619 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.dsx.2023.102780 |
| PMID: | 37201293 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-0334 |
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| DOI: | 10.1016/j.dsx.2023.102780 |