دورية أكاديمية
أعرض في EDS

Sex differences in emotion- and reward-related neural responses predicting increases in substance use in adolescence.

التفاصيل البيبلوغرافية
العنوان: Sex differences in emotion- and reward-related neural responses predicting increases in substance use in adolescence.
المؤلفون: Chaplin TM; Department of Psychology, George Mason University, 4400 University Drive, MSN 3F5, Fairfax, VA 22030, USA. Electronic address: tchaplin@gmu.edu., Curby TW; Department of Psychology, George Mason University, 4400 University Drive, MSN 3F5, Fairfax, VA 22030, USA., Gonçalves SF; Department of Psychology, George Mason University, 4400 University Drive, MSN 3F5, Fairfax, VA 22030, USA., Kisner MA; Department of Psychology, George Mason University, 4400 University Drive, MSN 3F5, Fairfax, VA 22030, USA., Niehaus CE; Department of Psychology, George Mason University, 4400 University Drive, MSN 3F5, Fairfax, VA 22030, USA; Department of Pediatrics, University of Louisville, 571 S Floyd Street, Louisville, KY 40202, USA., Thompson JC; Department of Psychology, George Mason University, 4400 University Drive, MSN 3F5, Fairfax, VA 22030, USA.
المصدر: Behavioural brain research [Behav Brain Res] 2023 Jul 26; Vol. 450, pp. 114499. Date of Electronic Publication: 2023 May 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Sex Characteristics* , Substance-Related Disorders*/diagnostic imaging , Substance-Related Disorders*/psychology, Humans ; Adolescent ; Male ; Female ; Child ; Reward ; Emotions ; Nucleus Accumbens/diagnostic imaging ; Nucleus Accumbens/physiology ; Magnetic Resonance Imaging ; Brain/diagnostic imaging
مستخلص: Adolescent substance use is a significant public health problem and there is a need for effective substance use preventions. To develop effective preventions, it is important to identify neurobiological risk factors that predict increases in substance use in adolescence and to understand potential sex differences in risk mechanisms. The present study used functional magnetic resonance imaging and hierarchical linear modeling to examine negative emotion- and reward-related neural responses in early adolescence predicting growth in substance use to middle adolescence in 81 youth, by sex. Adolescent neural responses to negative emotional stimuli and monetary reward receipt were assessed at age 12-14. Adolescents reported on substance use at age 12-14 and at 6 month, and 1, 2, and 3 year follow-ups. Adolescent neural responses did not predict initiation of substance use (yes/no), but, among users, neural responses predicted growth in substance use frequency. For girls, heightened right amygdala responses to negative emotional stimuli in early adolescence predicted growth in substance use frequency through middle adolescence. For boys, blunted left nucleus accumbens and bilateral ventromedial prefrontal cortex responses to monetary reward predicted growth in substance use frequency. Findings suggest different emotion and reward-related predictors of the development of substance use for adolescent girls versus boys.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: F31 DA051154 United States DA NIDA NIH HHS; R01 DA033431 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: Adolescence; Emotion; FMRI; Reward; Sex differences; Substance use
تواريخ الأحداث: Date Created: 20230518 Date Completed: 20230609 Latest Revision: 20240727
رمز التحديث: 20240727
مُعرف محوري في PubMed: PMC10330612
DOI: 10.1016/j.bbr.2023.114499
PMID: 37201893
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7549
DOI:10.1016/j.bbr.2023.114499