دورية أكاديمية
Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege.
| العنوان: | Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege. |
|---|---|
| المؤلفون: | Lorrey SJ; Department of Immunology, Duke University, Durham, NC, USA.; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA., Waibl Polania J; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA., Wachsmuth LP; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA.; Medical Scientist Training Program, Duke University, Durham, NC, USA., Hoyt-Miggelbrink A; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA., Tritz ZP; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Edwards R; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA., Wolf DM; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Johnson AJ; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Fecci PE; Department of Immunology, Duke University, Durham, NC, USA.; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA.; Department of Neurosurgery, Duke University, Durham, NC, USA., Ayasoufi K; Department of Immunology, Mayo Clinic, Rochester, MN, USA. |
| المصدر: | Neuro-oncology advances [Neurooncol Adv] 2023 Apr 11; Vol. 5 (1), pp. vdad035. Date of Electronic Publication: 2023 Apr 11 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101755003 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-2498 (Electronic) Linking ISSN: 26322498 NLM ISO Abbreviation: Neurooncol Adv Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Oxford University Press, [2019]- |
| مستخلص: | Background: The nervous and immune systems interact in a reciprocal manner, both under physiologic and pathologic conditions. Literature spanning various CNS pathologies including brain tumors, stroke, traumatic brain injury and de-myelinating diseases describes a number of associated systemic immunologic changes, particularly in the T-cell compartment. These immunologic changes include severe T-cell lymphopenia, lymphoid organ contraction, and T-cell sequestration within the bone marrow. Methods: We performed an in-depth systematic review of the literature and discussed pathologies that involve brain insults and systemic immune derangements. Conclusions: In this review, we propose that the same immunologic changes hereafter termed 'systemic immune derangements', are present across CNS pathologies and may represent a novel, systemic mechanism of immune privilege for the CNS. We further demonstrate that systemic immune derangements are transient when associated with isolated insults such as stroke and TBI but persist in the setting of chronic CNS insults such as brain tumors. Systemic immune derangements have vast implications for informed treatment modalities and outcomes of various neurologic pathologies. Competing Interests: None. All authors have read this manuscript and agree with the statements written. (© The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.) |
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| معلومات مُعتمدة: | K99 NS117799 United States NS NINDS NIH HHS; RF1 NS122174 United States NS NINDS NIH HHS; T32 GM145449 United States GM NIGMS NIH HHS; R00 NS117799 United States NS NINDS NIH HHS; T32 GM007171 United States GM NIGMS NIH HHS; R01 NS103212 United States NS NINDS NIH HHS; P50 CA190991 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: T-cells; brain injury; glioblastoma; lymphopenia; mmunosuppression |
| تواريخ الأحداث: | Date Created: 20230519 Latest Revision: 20240530 |
| رمز التحديث: | 20240530 |
| مُعرف محوري في PubMed: | PMC10191195 |
| DOI: | 10.1093/noajnl/vdad035 |
| PMID: | 37207119 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2632-2498 |
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| DOI: | 10.1093/noajnl/vdad035 |