دورية أكاديمية
Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress.
| العنوان: | Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress. |
|---|---|
| المؤلفون: | Liu WZ; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China.; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China., Wang CY; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China.; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China., Wang Y; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China.; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China., Cai MT; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China., Zhong WX; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China., Liu T; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China.; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China., Wang ZH; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China.; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China., Pan HQ; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China., Zhang WH; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China. whzhang@ncu.edu.cn.; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China. whzhang@ncu.edu.cn.; Jiangxi Provincial Key Laboratory of Interdisciplinary Science, Nanchang University, Nanchang, 330031, People's Republic of China. whzhang@ncu.edu.cn., Pan BX; Department of Biological Science, School of Life Science, Nanchang University, Nanchang, 330031, China. panbingxing@ncu.edu.cn.; Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, 330031, China. panbingxing@ncu.edu.cn. |
| المصدر: | Cell & bioscience [Cell Biosci] 2023 May 18; Vol. 13 (1), pp. 90. Date of Electronic Publication: 2023 May 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101561195 Publication Model: Electronic Cited Medium: Print ISSN: 2045-3701 (Print) Linking ISSN: 20453701 NLM ISO Abbreviation: Cell Biosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, 2011- |
| مستخلص: | Background: Chronic stress exposure increases the risk of mental health problems such as anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling stress responses through communicating with multiple limbic structures, including the basolateral amygdala (BLA) and nucleus accumbens (NAc). However, considering the complex topographical organization of the mPFC neurons in different subregions (dmPFC vs. vmPFC) and across multiple layers (Layer II/III vs. Layer V), the exact effects of chronic stress on these distinct mPFC output neurons remain largely unknown. Results: We first characterized the topographical organization of mPFC neurons projecting to BLA and NAc. Then, by using a typical mouse model of chronic restraint stress (CRS), we investigated the effects of chronic stress on the synaptic activity and intrinsic properties of the two mPFC neuronal populations. Our results showed that there was limited collateralization of the BLA- and NAc-projecting pyramidal neurons, regardless of the subregion or layer they were situated in. CRS significantly reduced the inhibitory synaptic transmission onto the BLA-projecting neurons in dmPFC layer V without any effect on the excitatory synaptic transmission, thus leading to a shift of the excitation-inhibition (E-I) balance toward excitation. However, CRS did not affect the E-I balance in NAc-projecting neurons in any subregions or layers of mPFC. Moreover, CRS also preferentially increased the intrinsic excitability of the BLA-projecting neurons in dmPFC layer V. By contrast, it even caused a decreasing tendency in the excitability of NAc-projecting neurons in vmPFC layer II/III. Conclusion: Our findings indicate that chronic stress exposure preferentially modulates the activity of the mPFC-BLA circuit in a subregion (dmPFC) and laminar (layer V) -dependent manner. (© 2023. The Author(s).) |
| References: | Brain Struct Funct. 2010 May;214(4):339-53. (PMID: 20221886) Neuropsychopharmacology. 2015 Nov;40(12):2666-75. (PMID: 25953359) Biol Psychiatry. 2015 Feb 1;77(3):212-222. (PMID: 25173629) Neurosci Biobehav Rev. 2019 Oct;105:39-51. (PMID: 31377218) Behav Neurosci. 2008 Apr;122(2):282-92. (PMID: 18410168) J Clin Invest. 2023 May 1;133(9):. (PMID: 36917193) J Neuroendocrinol. 2015 Jun;27(6):446-56. (PMID: 25737097) Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):359-64. (PMID: 18172209) Nat Commun. 2022 Sep 17;13(1):5462. (PMID: 36115848) Science. 2016 May 6;352(6286):aaf2669. (PMID: 26966193) J Neurophysiol. 2015 Oct;114(4):2376-89. (PMID: 26289465) Curr Opin Neurobiol. 2021 Jun;68:167-180. (PMID: 33930622) J Neurosci. 2007 Mar 14;27(11):2781-7. (PMID: 17360899) Int Rev Neurobiol. 2020;150:129-153. (PMID: 32204829) Brain Commun. 2020 Sep 26;2(2):fcaa153. (PMID: 33543135) Neurosci Biobehav Rev. 2003 Oct;27(6):555-79. (PMID: 14599436) Physiol Genomics. 2019 Sep 1;51(9):432-442. (PMID: 31373533) Neuroscience. 2018 Oct 15;390:265-277. (PMID: 30179643) Front Cell Neurosci. 2018 Jan 30;12:24. (PMID: 29440995) Biol Psychiatry. 2017 May 15;81(10):886-897. (PMID: 27449797) Neurobiol Stress. 2019 Mar 08;10:100152. (PMID: 30937357) Biol Psychiatry. 2021 Aug 1;90(3):194-205. (PMID: 33867113) Behav Brain Res. 2016 May 1;304:120-4. (PMID: 26802727) Front Behav Neurosci. 2014 Feb 17;8:43. (PMID: 24596546) Neuropsychopharmacology. 2012 Jan;37(1):4-15. (PMID: 21956446) Eur J Pharmacol. 2021 Sep 5;906:174231. (PMID: 34090896) Horm Behav. 2005 Jun;48(1):1-10. (PMID: 15919381) Neuropsychopharmacology. 2011 Jan;36(2):529-38. (PMID: 20962768) Neuropsychopharmacology. 2023 Apr;48(5):734-744. (PMID: 36513871) Dev Neurobiol. 2011 Jan 1;71(1):45-61. (PMID: 21154909) Biol Psychiatry. 2019 May 15;85(10):812-828. (PMID: 30737013) Neuropsychopharmacology. 2019 Mar;44(4):766-775. (PMID: 30470839) Nat Rev Neurosci. 2004 Oct;5(10):793-807. (PMID: 15378039) J Neurosci. 2010 Dec 1;30(48):16188-96. (PMID: 21123565) J Neurophysiol. 2018 Jan 01;119(1):177-191. (PMID: 28978762) Neuron. 2012 Aug 9;75(3):503-16. (PMID: 22884333) Biol Psychiatry. 2019 Mar 15;85(6):443-453. (PMID: 30470559) Neurobiol Stress. 2019 Apr 13;10:100165. (PMID: 31193524) Sci Rep. 2019 Jul 1;9(1):9479. (PMID: 31263213) Acta Neuropsychiatr. 2018 Apr;30(2):117-122. (PMID: 28566105) Nat Commun. 2020 May 6;11(1):2221. (PMID: 32376858) Behav Brain Res. 2022 Jan 7;416:113523. (PMID: 34390801) Mol Psychiatry. 2019 Oct;24(10):1461-1477. (PMID: 30886335) Trends Neurosci. 2021 Jul;44(7):550-563. (PMID: 33972100) Mol Psychiatry. 2015 Mar;20(3):377-87. (PMID: 25600109) J Neurosci Res. 2014 Aug;92(8):1044-53. (PMID: 24752881) Transl Psychiatry. 2018 Apr 18;8(1):85. (PMID: 29666363) Annu Rev Psychol. 2016;67:239-61. (PMID: 26442668) Biol Psychiatry. 2021 May 1;89(9):847-856. (PMID: 33691931) Neuroscience. 2019 Jan 1;396:24-35. (PMID: 30448452) Cell Rep. 2020 Jul 28;32(4):107965. (PMID: 32726629) Nat Commun. 2020 Sep 8;11(1):4484. (PMID: 32901027) Nat Med. 2018 May;24(5):658-666. (PMID: 29662202) Brain Behav Immun. 2021 Jan;91:505-518. (PMID: 33161163) Front Cell Neurosci. 2018 Jun 20;12:148. (PMID: 29973870) eNeuro. 2020 Mar 6;7(2):. (PMID: 31548367) Neuron. 2016 Jul 20;91(2):260-92. (PMID: 27477017) |
| معلومات مُعتمدة: | 82101589 National Natural Science Foundation of China; 32160193 National Natural Science Foundation of China; 31970953 National Natural Science Foundation of China; 82125010 National Natural Science Foundation of China; 81930032 National Natural Science Foundation of China; 32222034 National Natural Science Foundation of China; 2021TQ0138 China Postdoctoral Science Foundation; 2021M701545 China Postdoctoral Science Foundation; 20212ACB206038 Natural Science Foundation of Jiangxi Province; 2021ZD0202704 National Key R&D Program of China |
| فهرسة مساهمة: | Keywords: Amygdala; Anxiety; Chronic stress; Neuronal circuit; Prefrontal cortex; Synaptic transmission |
| تواريخ الأحداث: | Date Created: 20230519 Latest Revision: 20230522 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10197342 |
| DOI: | 10.1186/s13578-023-01050-2 |
| PMID: | 37208769 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-3701 |
|---|---|
| DOI: | 10.1186/s13578-023-01050-2 |