دورية أكاديمية
Repetitive transcranial magnetic stimulation and fluoxetine reverse depressive-like behavior but with differential effects on Olig2-positive cells in chronically stressed mice.
| العنوان: | Repetitive transcranial magnetic stimulation and fluoxetine reverse depressive-like behavior but with differential effects on Olig2-positive cells in chronically stressed mice. |
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| المؤلفون: | Ramírez-Rodríguez GB; Laboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñiz', Calzada México-Xochimilco 101, Alcaldía Tlalpan, C.P, 14370, Ciudad de México, Mexico. Electronic address: gbernabe@imp.edu.mx., Meneses San-Juan D; Laboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñiz', Calzada México-Xochimilco 101, Alcaldía Tlalpan, C.P, 14370, Ciudad de México, Mexico., Rico-Becerra AI; Laboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñiz', Calzada México-Xochimilco 101, Alcaldía Tlalpan, C.P, 14370, Ciudad de México, Mexico; Licenciatura en Neurociencias, Facultad de Medicina. Universidad Nacional Autónoma de México. Circuito Interior, Avenida Universidad 3000, Ciudad Universitaria, Alcaldía Coyoacán, C.P, 04510, Ciudad de México, Mexico., González-Olvera JJ; Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñiz', Calzada México-Xochimilco 101. Alcaldía Tlalpan, C.P, 14370, Ciudad de México, Mexico., Reyes-Galindo V; Instituto de Ecología. Universidad Nacional Autónoma de México. Circuito Interior, Avenida Universidad 3000, Ciudad Universitaria. Alcaldía Coyoacán, C.P, 04510, Ciudad de México, Mexico. |
| المصدر: | Neuropharmacology [Neuropharmacology] 2023 Sep 15; Vol. 236, pp. 109567. Date of Electronic Publication: 2023 May 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Pergamon Press Original Publication: Oxford, New York, Pergamon. |
| مواضيع طبية MeSH: | Fluoxetine*/pharmacology , Fluoxetine*/therapeutic use , Transcranial Magnetic Stimulation*/methods, Mice ; Animals ; Female ; Ki-67 Antigen ; Antidepressive Agents/therapeutic use ; Doublecortin Domain Proteins ; Oligodendrocyte Transcription Factor 2 |
| مستخلص: | Depression is a mood disorder coursing with several behavioral, cellular, and neurochemical alterations. The negative impact of chronic stress may precipitate this neuropsychiatric disorder. Interestingly, downregulation of oligodendrocyte-related genes, abnormal myelin structure, and reduced numbers and density of oligodendrocytes in the limbic system have been identified in patients diagnosed with depression, but also in rodents exposed to chronic mild stress (CMS). Several reports have emphasized the importance of pharmacological or stimulation-related strategies in influencing oligodendrocytes in the hippocampal neurogenic niche. Repetitive transcranial magnetic stimulation (rTMS) has gained attention as an intervention to revert depression. Here, we hypothesized that 5 Hz (Hz) of rTMS or Fluoxetine (Flx) would revert depressive-like behaviors by influencing oligodendrocytes and revert neurogenic alterations caused by CMS in female Swiss Webster mice. Our results showed that 5 Hz rTMS or Flx revert depressive-like behavior. Only rTMS influenced oligodendrocytes by increasing the number of Olig2-positive cells in the hilus of the dentate gyrus and the prefrontal cortex. However, both strategies exerted effects on some events of the hippocampal neurogenic processes, such as cell proliferation (Ki67-positive cells), survival (CldU-positive cells), and intermediate stages (doublecortin-positive cells) along the dorsal-ventral axis of this region. Interestingly, the combination of rTMS-Flx exerted antidepressant-like effects, but the increased number of Olig2-positive cells observed in mice treated only with rTMS was canceled. However, rTMS-Flx exerted a synergistic effect by increasing the number of Ki67-positive cells. It also increased the number of CldU- and doublecortin-positive cells in the dentate gyrus. Our results demonstrate that 5 Hz rTMS has beneficial effects, as it reverted depressive-like behavior by increasing the number of Olig2-positive cells and reverting the decrement in hippocampal neurogenesis in CMS-exposed mice. Nevertheless, the effects of rTMS on other glial cells require further investigation. Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This work was financially supported by INPRFM (SIC-2000) to GBRR. The equipment for this study was kindly financed by CONACYT (Grant Infraestructura 2015; 254773 to GBRR). INPRFM and CONACYT did not influence on the decision to publish the results included in this manuscript. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Adult neurogenesis; Chronic mild stress; Dentate gyrus; Fluoxetine; Hippocampus; Olig2; Oligodendrocytes; Prefrontal cortex; Repetitive transcranial magnetic stimulation |
| المشرفين على المادة: | 01K63SUP8D (Fluoxetine) 0 (Ki-67 Antigen) 0 (Antidepressive Agents) 0 (Doublecortin Domain Proteins) 0 (Olig2 protein, mouse) 0 (Oligodendrocyte Transcription Factor 2) |
| تواريخ الأحداث: | Date Created: 20230520 Date Completed: 20230612 Latest Revision: 20231116 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.neuropharm.2023.109567 |
| PMID: | 37209812 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7064 |
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| DOI: | 10.1016/j.neuropharm.2023.109567 |