دورية أكاديمية
أعرض في EDS

Binaural acoustic stimulation in patients with Parkinson's disease.

التفاصيل البيبلوغرافية
العنوان: Binaural acoustic stimulation in patients with Parkinson's disease.
المؤلفون: Calvano A; Department of Neurology, Philipps-University Marburg, Marburg, Germany., Timmermann L; Department of Neurology, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Philipps-University Marburg, Marburg, Germany., Loehrer PA; Department of Neurology, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Philipps-University Marburg, Marburg, Germany., Oehrn CR; Department of Neurology, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Philipps-University Marburg, Marburg, Germany., Weber I; Department of Neurology, Philipps-University Marburg, Marburg, Germany.
المصدر: Frontiers in neurology [Front Neurol] 2023 May 05; Vol. 14, pp. 1167006. Date of Electronic Publication: 2023 May 05 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation, 2010]-
مستخلص: Acoustic stimulation can improve motor symptoms in Parkinson's disease (PD) and might therefore represent a potential non-invasive treatment option. Scalp electroencephalography studies in healthy subjects indicate that specifically binaural beat stimulation (BBS) in the gamma frequency range is associated with synchronized cortical oscillations at 40 Hertz (Hz). Several studies suggest that oscillations in the gamma-frequency range (>30 Hz) serve a prokinetic function in PD. In this double-blind, randomized study, 25 PD patients were recruited. The study was conducted with (ON) and without dopaminergic medication (OFF). Each drug condition consisted of two phases (no stimulation and acoustic stimulation). The acoustic stimulation phase was divided into two blocks including BBS and conventional acoustic stimulation (CAS) as a control condition. For BBS, a modulated frequency of 35 Hz was used (left: 320 Hz; right: 355 Hz) and for CAS 340 Hz on both sides. We assessed effects on motor performance using Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and two validated commercially available portable devices (Kinesia ONE™ and Kinesia 360™) measuring motor symptoms such as dyskinesia, bradykinesia, and tremor. Repeated measures ANOVA revealed that BBS improved resting tremor on the side of the more affected limb in the OFF condition, as measured by wearables ( F (2,48) = 3.61, p = 0.035). However, BBS did not exert a general positive effect on motor symptoms as assessed via MDS-UPDRS ( F (2,48) = 1.00, p = 0.327). For CAS, we did not observe an improvement in specific symptoms but rather an overall beneficial effect on motor performance (MDS-UPDRS total score OFF medication: F (2,48) = 4.17, p = 0.021; wearable scores: F (2,48) = 2.46, p = 0.097). In this study, we found an improvement of resting tremor when applying BBS in the gamma frequency band OFF medication. Moreover, the positive effects of CAS underline the general positive potential for improvement of motor function by acoustically supported therapeutic approaches. However, more studies are needed to fully characterize the clinical relevance of BBS and to further optimize its ameliorating effects.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Calvano, Timmermann, Loehrer, Oehrn and Weber.)
References: J Neurosci. 2016 Jun 15;36(24):6445-58. (PMID: 27307233)
Am J Clin Hypn. 2000 Jul;43(1):53-69. (PMID: 10911677)
Psychol Res. 2017 Jan;81(1):271-277. (PMID: 26612201)
Clin Neurophysiol. 2005 Mar;116(3):658-68. (PMID: 15721080)
Front Neurol. 2018 Aug 03;9:628. (PMID: 30123178)
Parkinsonism Relat Disord. 2019 Jul;64:132-137. (PMID: 30948242)
Lancet Neurol. 2016 Nov;15(12):1257-1272. (PMID: 27751556)
J Exp Pharmacol. 2021 Apr 29;13:469-485. (PMID: 33953618)
J Neurosci. 2002 Dec 1;22(23):10501-6. (PMID: 12451150)
Front Aging Neurosci. 2014 Oct 21;6:249. (PMID: 25374538)
Cereb Cortex. 2008 May;18(5):1193-200. (PMID: 17827173)
Elife. 2018 Feb 01;7:. (PMID: 29388913)
J Neurophysiol. 2014 Oct 15;112(8):1871-84. (PMID: 25008412)
J Am Med Dir Assoc. 2018 Dec;19(12):1054-1062. (PMID: 30471799)
Front Psychiatry. 2015 Jun 04;6:82. (PMID: 26089802)
Int J Neural Syst. 2018 Jun;28(5):1750055. (PMID: 29297265)
Curr Opin Neurol. 2013 Dec;26(6):662-70. (PMID: 24150222)
PLoS One. 2012;7(4):e34789. (PMID: 22496862)
Mov Disord. 2015 Oct;30(12):1632-8. (PMID: 25649812)
Sci Rep. 2017 Feb 24;7:42005. (PMID: 28233776)
Int J Psychophysiol. 2014 Dec;94(3):399-406. (PMID: 25448376)
eNeuro. 2020 Mar 19;7(2):. (PMID: 32066611)
Brain. 2012 Nov;135(Pt 11):3206-26. (PMID: 22382359)
Am J Clin Hypn. 2003 Apr;45(4):295-309. (PMID: 12722933)
Front Psychiatry. 2015 May 12;6:70. (PMID: 26029120)
Front Aging Neurosci. 2020 Aug 14;12:243. (PMID: 32922283)
Mov Disord. 2015 Oct;30(12):1591-601. (PMID: 26474316)
Healthcare (Basel). 2020 Apr 28;8(2):. (PMID: 32353963)
Mov Disord. 2009 Apr 15;24(5):723-30. (PMID: 19133661)
Brain. 2012 Sep;135(Pt 9):2766-78. (PMID: 22858550)
J Neurosci. 2012 Aug 1;32(31):10541-53. (PMID: 22855804)
Mov Disord. 2018 Jan;33(1):75-87. (PMID: 29193359)
Handb Clin Neurol. 2022;184:259-271. (PMID: 35034740)
Psychol Res. 2019 Mar;83(2):357-372. (PMID: 30073406)
Sci Am. 1973 Oct;229(4):94-102. (PMID: 4727697)
NeuroRehabilitation. 2009;25(4):297-306. (PMID: 20037223)
Anesth Analg. 2010 Jan 1;110(1):208-10. (PMID: 19861358)
Neurosci Biobehav Rev. 2016 Mar;62:76-88. (PMID: 26773722)
Eur J Neurosci. 2015 Jan;41(2):254-63. (PMID: 25345689)
Sci Rep. 2021 Sep 30;11(1):19530. (PMID: 34593924)
Sci Rep. 2018 Jan 11;8(1):506. (PMID: 29323122)
J Altern Complement Med. 2011 Apr;17(4):351-5. (PMID: 21480784)
Front Neurosci. 2018 Mar 26;12:178. (PMID: 29662434)
J Altern Complement Med. 2007 Mar;13(2):199-206. (PMID: 17388762)
Parkinsonism Relat Disord. 2021 Mar;84:105-111. (PMID: 33607526)
Neuromodulation. 2015 Jul;18(5):349-54. (PMID: 25879998)
NeuroRehabilitation. 2006;21(1):29-36. (PMID: 16720935)
J Parkinsons Dis. 2016 Jul 2;6(3):631-8. (PMID: 27392872)
Curr Neuropharmacol. 2018;16(8):1239-1252. (PMID: 28494719)
Sci Transl Med. 2021 Feb 3;13(579):. (PMID: 33536284)
Front Hum Neurosci. 2017 Nov 15;11:557. (PMID: 29187819)
Front Psychol. 2016 Aug 24;7:1287. (PMID: 27605922)
Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S60-4. (PMID: 26360239)
Sci Rep. 2020 Apr 24;10(1):7002. (PMID: 32332827)
Front Hum Neurosci. 2013 Nov 14;7:786. (PMID: 24294202)
Nat Rev Neurol. 2017 Sep;13(9):548-554. (PMID: 28752857)
فهرسة مساهمة: Keywords: Parkinson’s disease; acoustic stimulation; binaural beats; brainwave entrainment; motor symptoms
تواريخ الأحداث: Date Created: 20230522 Latest Revision: 20230523
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10196363
DOI: 10.3389/fneur.2023.1167006
PMID: 37213909
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2295
DOI:10.3389/fneur.2023.1167006