دورية أكاديمية
أعرض في EDS

Acute idiopathic pancreatitis is associated with more aggressive disease course in Crohn's disease but not in ulcerative colitis.

التفاصيل البيبلوغرافية
العنوان: Acute idiopathic pancreatitis is associated with more aggressive disease course in Crohn's disease but not in ulcerative colitis.
المؤلفون: Osman KT; Department of Internal Medicine, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA. ktarek.osman@gmail.com.; Department of Internal Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Clinic, Burlington, 01803, MA, USA. ktarek.osman@gmail.com., Hoque A; Department of Internal Medicine, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA., Pasam RT; Department of Internal Medicine, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA., Farhoud A; Department of Gastroenterology and Hepatology, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA., Abdelfattah A; Department of Gastroenterology and Hepatology, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA., Ramadorai V; Department of Gastroenterology and Hepatology, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA., Chaudrey K; Department of Gastroenterology and Hepatology, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA., Pellish R; Department of Gastroenterology and Hepatology, Lahey Hospital and Medical Center, Tufts Medical School, Burlington, 01805, MA, USA.
المصدر: BMC gastroenterology [BMC Gastroenterol] 2023 May 22; Vol. 23 (1), pp. 171. Date of Electronic Publication: 2023 May 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Crohn Disease*/complications , Crohn Disease*/diagnosis , Crohn Disease*/surgery , Colitis, Ulcerative*/complications , Colitis, Ulcerative*/diagnosis , Pancreatitis*/complications , Inflammatory Bowel Diseases*/complications , Biological Products*, Humans ; Acute Disease ; Disease Progression
مستخلص: Purpose: Patients with inflammatory bowel disease (IBD), whether Crohn's disease (CD) or ulcerative colitis (UC), have an increased risk of acute pancreatitis. The prognostic value of diagnosing acute idiopathic pancreatitis in patients with IBD is not well understood.
Methods: A retrospective review of 56 patients with IBD and acute pancreatitis was conducted in a tertiary center from 2011 to 2020. Aggressive disease course was defined as (i)biologic change, (ii)biologic dose escalation, or (iii)IBD-related surgeries occurring within 1 year of acute pancreatitis diagnosis. Logistic regression modelling identified associations between covariates and an aggressive disease course.
Results: Baseline characteristics between idiopathic pancreatitis and other causes of acute pancreatitis, in both CD and UC cohorts, were similar. Idiopathic pancreatitis was significantly associated with an aggressive disease course in CD (P = 0.04). No confounding factors were associated with an aggressive disease course in CD. Idiopathic pancreatitis, however, was not associated with an aggressive disease course in UC (P = 0.35).
Conclusion: The diagnosis of acute idiopathic pancreatitis may provide a prognostic indicator of a more severe disease course in CD. No such association appears to exist with UC. To the best of our knowledge, this is the first study that identifies an association and possible prognostic value between idiopathic pancreatitis and a more severe disease course in CD. More studies with a larger sample size are needed to validate these findings, further define idiopathic pancreatitis as an extraintestinal manifestation of IBD and elucidate a clinical strategy to optimize care in patients with aggressive CD and idiopathic pancreatitis.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Crohn’s disease; Extra-intestinal manifestations; IBD; Pancreatitis; Prognosis
المشرفين على المادة: 0 (Biological Products)
تواريخ الأحداث: Date Created: 20230522 Date Completed: 20230524 Latest Revision: 20230525
رمز التحديث: 20230525
مُعرف محوري في PubMed: PMC10201786
DOI: 10.1186/s12876-023-02790-8
PMID: 37217857
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-230X
DOI:10.1186/s12876-023-02790-8