دورية أكاديمية
أعرض في EDS

The Impact of Potentially Inappropriate Medications and Polypharmacy on 3-Month Hospital Readmission among Older Patients: A Retrospective Cohort Study from Malaysia.

التفاصيل البيبلوغرافية
العنوان: The Impact of Potentially Inappropriate Medications and Polypharmacy on 3-Month Hospital Readmission among Older Patients: A Retrospective Cohort Study from Malaysia.
المؤلفون: Akkawi ME; Department of Pharmacy Practice, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25150, Malaysia.; Quality Use of Medicines Research Group, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25150, Malaysia., Abd Aziz HH; Department of Pharmacy Practice, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25150, Malaysia., Fata Nahas AR; Department of Pharmacy Practice, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25150, Malaysia.; Quality Use of Medicines Research Group, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25150, Malaysia.
المصدر: Geriatrics (Basel, Switzerland) [Geriatrics (Basel)] 2023 Apr 30; Vol. 8 (3). Date of Electronic Publication: 2023 Apr 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101704019 Publication Model: Electronic Cited Medium: Internet ISSN: 2308-3417 (Electronic) Linking ISSN: 23083417 NLM ISO Abbreviation: Geriatrics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI AG
مستخلص: Introduction: Potentially inappropriate medications (PIMs) use and polypharmacy are two issues that are commonly encountered among older people. They are associated with several negative outcomes including adverse drug reactions and medication-related hospitalization. There are insufficient studies regarding the impact of both PIMs and polypharmacy on hospital readmission, especially in Malaysia.
Aim: To investigate the possible association between polypharmacy and prescribing PIMs at discharge and 3-month hospital readmission among older patients.
Materials and Method: A retrospective cohort study involved 600 patients ≥60 years discharged from the general medical wards in a Malaysian teaching hospital. The patients were divided into two equal groups: patients with or without PIMs. The main outcome was any readmission during the 3-month follow-up. The discharged medications were assessed for polypharmacy (≥five medications) and PIMs (using 2019 Beers' criteria). Chi-square test, Mann-Whitney test, and a multiple logistic regression were conducted to study the impact of PIMs/polypharmacy on 3-month hospital readmission.
Results: The median number for discharge medications were six and five for PIMs and non-PIMs patients, respectively. The most frequently prescribed PIMs was aspirin as primary prevention of cardiovascular diseases (33.43%) followed by tramadol (13.25%). The number of medications at discharge and polypharmacy status were significantly associated with PIMs use. Overall, 152 (25.3%) patients were re-admitted. Polypharmacy and PIMs at discharge did not significantly impact the hospital readmission. After applying the logistic regression, only male gender was a predictor for 3-month hospital readmission (OR: 2.07, 95% CI: 1.022-4.225).
Conclusion: About one-quarter of the patients were admitted again within three months of discharge. PIMs and polypharmacy were not significantly associated with 3-month hospital readmissions while male gender was found to be an independent risk factor for readmission.
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معلومات مُعتمدة: RC-RIGS20-006-0006 International Islamic University Malaysia
فهرسة مساهمة: Keywords: Malaysia; hospital readmission; older patients; polypharmacy; potentially inappropriate medication
تواريخ الأحداث: Date Created: 20230523 Latest Revision: 20230525
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10204541
DOI: 10.3390/geriatrics8030049
PMID: 37218829
قاعدة البيانات: MEDLINE
الوصف
تدمد:2308-3417
DOI:10.3390/geriatrics8030049