التفاصيل البيبلوغرافية
| العنوان: |
The Effect of Targeted Temperature Management on the Metabolome Following Out-of-Hospital Cardiac Arrest. |
| المؤلفون: |
Beske RP; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Obling LER; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Bro-Jeppesen J; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Nielsen N; Department of Clinical Sciences at Helsingborg, Lund University, Lund, Sweden., Meyer MAS; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Kjaergaard J; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Johansson PI; Department of Clinical Immunology, Center for Endotheliomics, CAG, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hassager C; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
| المصدر: |
Therapeutic hypothermia and temperature management [Ther Hypothermia Temp Manag] 2023 Dec; Vol. 13 (4), pp. 208-215. Date of Electronic Publication: 2023 May 23. |
| نوع المنشور: |
Randomized Controlled Trial; Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101543518 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2153-7933 (Electronic) Linking ISSN: 21537658 NLM ISO Abbreviation: Ther Hypothermia Temp Manag Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
| مواضيع طبية MeSH: |
Hypothermia, Induced*/methods , Out-of-Hospital Cardiac Arrest*/therapy , Cardiopulmonary Resuscitation*/methods, Humans ; Cold Temperature ; Metabolome ; Amino Acids |
| مستخلص: |
Targeted temperature management (TTM) may moderate the injury from out-of-hospital cardiac arrest. Slowing the metabolism has been a suggested effect. Nevertheless, studies have found higher lactate levels in patients cooled to 33°C compared with 36°C even days from TTM cessation. Larger studies have not been performed on the TTM's effect on the metabolome. Accordingly, to explore the effect of TTM, we used ultra-performance liquid-mass spectrometry in a substudy of 146 patients randomized in the TTM trial to either 33°C or 36°C for 24 hours and quantified 60 circulating metabolites at the time of hospital arrival (T 0 ) and 48 hours later (T 48 ). From T 0 to T 48, profound changes to the metabolome were observed: tricarboxylic acid (TCA) cycle metabolites, amino acids, uric acid, and carnitine species all decreased. TTM significantly modified these changes in nine metabolites (Benjamini-Hochberg corrected false discovery rate <0.05): branched amino acids valine and leucine levels dropped more in the 33°C arm (change [95% confidence interval]: -60.9 μM [-70.8 to -50.9] vs. -36.0 μM [-45.8 to -26.3] and -35.5 μM [-43.1 to -27.8] vs. -21.2 μM [-28.7 to -13.6], respectively), whereas the TCA metabolites including malic acid and 2-oxoglutaric acid remained higher for the first 48 hours (-7.7 μM [-9.7 to -5.7] vs. -10.4 μM [-12.4 to -8.4] and -3 μM [-4.3 to -1.7] vs. -3.7 μM [-5 to -2.3]). Prostaglandin E2 only dropped in the TTM 36°C group. The results show that TTM affects the metabolism hours after normothermia have been reached. Clinical Trial Number: NCT01020916. |
| فهرسة مساهمة: |
Keywords: metabolism; out-of-hospital cardiac arrest; targeted temperature management |
| سلسلة جزيئية: |
ClinicalTrials.gov NCT01020916 |
| المشرفين على المادة: |
0 (Amino Acids) |
| تواريخ الأحداث: |
Date Created: 20230523 Date Completed: 20231204 Latest Revision: 20231204 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1089/ther.2022.0065 |
| PMID: |
37219970 |
| قاعدة البيانات: |
MEDLINE |
