دورية أكاديمية
The Effect of Targeted Temperature Management on the Metabolome Following Out-of-Hospital Cardiac Arrest.
العنوان: | The Effect of Targeted Temperature Management on the Metabolome Following Out-of-Hospital Cardiac Arrest. |
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المؤلفون: | Beske RP; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Obling LER; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Bro-Jeppesen J; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Nielsen N; Department of Clinical Sciences at Helsingborg, Lund University, Lund, Sweden., Meyer MAS; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Kjaergaard J; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Johansson PI; Department of Clinical Immunology, Center for Endotheliomics, CAG, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hassager C; Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
المصدر: | Therapeutic hypothermia and temperature management [Ther Hypothermia Temp Manag] 2023 Dec; Vol. 13 (4), pp. 208-215. Date of Electronic Publication: 2023 May 23. |
نوع المنشور: | Randomized Controlled Trial; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101543518 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2153-7933 (Electronic) Linking ISSN: 21537658 NLM ISO Abbreviation: Ther Hypothermia Temp Manag Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
مواضيع طبية MeSH: | Hypothermia, Induced*/methods , Out-of-Hospital Cardiac Arrest*/therapy , Cardiopulmonary Resuscitation*/methods, Humans ; Cold Temperature ; Metabolome ; Amino Acids |
مستخلص: | Targeted temperature management (TTM) may moderate the injury from out-of-hospital cardiac arrest. Slowing the metabolism has been a suggested effect. Nevertheless, studies have found higher lactate levels in patients cooled to 33°C compared with 36°C even days from TTM cessation. Larger studies have not been performed on the TTM's effect on the metabolome. Accordingly, to explore the effect of TTM, we used ultra-performance liquid-mass spectrometry in a substudy of 146 patients randomized in the TTM trial to either 33°C or 36°C for 24 hours and quantified 60 circulating metabolites at the time of hospital arrival (T |
فهرسة مساهمة: | Keywords: metabolism; out-of-hospital cardiac arrest; targeted temperature management |
سلسلة جزيئية: | ClinicalTrials.gov NCT01020916 |
المشرفين على المادة: | 0 (Amino Acids) |
تواريخ الأحداث: | Date Created: 20230523 Date Completed: 20231204 Latest Revision: 20231204 |
رمز التحديث: | 20240628 |
DOI: | 10.1089/ther.2022.0065 |
PMID: | 37219970 |
قاعدة البيانات: | MEDLINE |
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