دورية أكاديمية
International cohort of 382 children with lupus nephritis - presentation, treatment and outcome at 24 months.
| العنوان: | International cohort of 382 children with lupus nephritis - presentation, treatment and outcome at 24 months. |
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| المؤلفون: | De Mutiis C; Paediatric Unit, Maggiore Hospital, Azienda USL, Bologna, Italy. chiarademutiis@yahoo.com., Wenderfer SE; Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA., Basu B; Division of Pediatric Nephrology, Department of Pediatrics, Nilratan Sircar Medical College and Hospital, Kolkata, India., Bagga A; Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India., Orjuela A; Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA., Sar T; Division of Pediatric Nephrology, Department of Pediatrics, Nilratan Sircar Medical College and Hospital, Kolkata, India., Aggarwal A; Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India., Jain A; Department of Clinical Immunology and Rheumatology, Sawai Mansingh Medical College, Jaipur, India., Yap HK; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Teo S; Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, Singapore, Singapore., Ito S; Department of Pediatrics, Yokohama City University, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa, Japan., Ohnishi A; Department of Pediatrics, Yokohama City University, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa, Japan., Iwata N; Department of Infection and Immunology, Aichi Children's Health and Medical Center, Obu, Japan., Kasapcopur O; Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey., Yildiz M; Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey., Laurent A; Department of Pediatric Nephrology, Rheumatology and Dermatology, Hospices Civils de Lyon, Lyon, France., Mastrangelo A; Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Ogura M; Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan., Shima Y; Department of Pediatrics, Wakayama Medical University, Wakayama, Japan., Rianthavorn P; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Silva CA; Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Trindade V; Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Gianviti A; Division of Nephrology and Dialysis, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy., Akinori M; Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan., Hamada R; Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan., Fujimura J; Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan., Minamikawa S; Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan., Kamiyoshi N; Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan., Kaito H; Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan., Ishimori S; Department of Pediatrics, Aijinkai Takatsuki General Hospital, Osaka, Japan., Iannuzzella F; Nephrology and Dialysis Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy., Tullus K; Paediatric Nephrology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK. |
| المصدر: | Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2023 Nov; Vol. 38 (11), pp. 3699-3709. Date of Electronic Publication: 2023 May 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer International Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Lupus Nephritis*/diagnosis , Lupus Nephritis*/drug therapy , Lupus Nephritis*/pathology, Adolescent ; Child ; Female ; Humans ; Male ; Cyclophosphamide/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Kidney/pathology ; Mycophenolic Acid/therapeutic use ; Remission Induction ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Background: Children with lupus have a higher chance of nephritis and worse kidney outcome than adult patients. Methods: We retrospectively analyzed clinical presentation, treatment and 24-month kidney outcome in a cohort of 382 patients (≤ 18 years old) with lupus nephritis (LN) class ≥ III diagnosed and treated in the last 10 years in 23 international centers. Results: The mean age at onset was 11 years 9 months and 72.8% were females. Fifty-seven percent and 34% achieved complete and partial remission at 24-month follow-up, respectively. Patients with LN class III achieved complete remission more often than those with classes IV or V (mixed and pure). Only 89 of 351 patients maintained stable complete kidney remission from the 6 th to 24 th months of follow-up. eGFR ≥ 90 ml/min/1.73 m 2 at diagnosis and biopsy class III were predictive of stable kidney remission. The youngest and the oldest age quartiles (2y-9y, 5m) (14y, 2m-18y,2m) showed lower rates of stable remission (17% and 20.7%, respectively) compared to the two other age groups (29.9% and 33.7%), while there was no difference in gender. No difference in achieving stable remission was found between children who received mycophenolate or cyclophosphamide as induction treatment. Conclusion: Our data show that the rate of complete remission in patients with LN is still not high enough. Severe kidney involvement at diagnosis was the most important risk factor for not achieving stable remission while different induction treatments did not impact outcome. Randomized treatment trials involving children and adolescents with LN are needed to improve outcome for these children. A higher resolution version of the Graphical abstract is available as Supplementary information. (© 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association.) |
| References: | Oni L, Wright RD, Marks S, Beresford MW, Tullus K (2021) Kidney outcomes for children with lupus nephritis. Pediatr Nephrol 36:1377–1385. (PMID: 10.1007/s00467-020-04686-132725543) Bennett M, Brunner HI (2013) Biomarkers and updates on pediatrics lupus nephritis. Rheum Dis Clin North Am 39:833–853. (PMID: 10.1016/j.rdc.2013.05.001241828574980821) Tektonidou MG, Lewandowski LB, Hu J, Dasgupta A, Ward MM (2017) Survival in adults and children with systemic lupus erythematosus: a systematic review and Bayesian meta-analysis of studies from 1950 to 2016. Ann Rheum Dis 76:2009–2016. (PMID: 10.1136/annrheumdis-2017-21166328794077) Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Brogan P, Dolezalova P, Feldman B, Kone-Paut I, Lahdenne P, Marks SD, McCann L, Ozen S, Pilkington C, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW (2017) European evidence-based recommendations for the diagnosis and treatment of childhood-onset lupus nephritis: the SHARE initiative. Ann Rheum Dis 76:1965–1973. (PMID: 10.1136/annrheumdis-2017-21189828877866) Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group (2012) KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int (Suppl 2):221–232. Bertsias GK, Tektonidou M, Amoura Z, Aringer M, Bajema I, Berden JH, Boletis J, Cervera R, Dörner T, Doria A, Ferrario F, Floege J, Houssiau FA, Ioannidis JP, Isenberg DA, Kallenberg CG, Lightstone L, Marks SD, Martini A, Moroni G, Neumann I, Praga M, Schneider M, Starra A, Tesar V, Vasconcelos C, van Vollenhoven RF, Zakharova H, Haubitz M, Gordon C, Jayne D, Boumpas DT (2012) Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis 71:1771–1782. (PMID: 10.1136/annrheumdis-2012-20194022851469) Suhlrie A, Hennies I, Gellermann J, Büscher A, Hoyer P, Waldegger S, Wygoda S, Beetz R, Lange-Sperandio B, Klaus G, Konrad M, Holder M, Staude H, Rascher W, Oh J, Pape L, Tönshoff B, Haffner D; German Society of Paediatric Nephrology (2020) Twelve-month outcome in juvenile proliferative lupus nephritis: results of the German registry study. Pediatr Nephrol 35:1235–1246. (PMID: 10.1007/s00467-020-04501-x32193650) Markowitz GS, D’Agati VD (2007) The ISN/RPS 2003 classification of lupus nephritis: an assessment at 3 years. Kidney Int 71:491–495. (PMID: 10.1038/sj.ki.500211817264872) Bajema IM, Wilhelmus S, Alpers CE, Bruijn JA, Colvin RB, Cook HT, D'Agati VD, Ferrario F, Haas M, Jennette JC, Joh K, Nast CC, Noël LH, Rijnink EC, Roberts ISD, Seshan SV, Sethi S, Fogo AB (2018) Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices. Kidney Int 93:789–796. (PMID: 10.1016/j.kint.2017.11.02329459092) Laboratory Handbook Group (2021) Sheffield Children’s Hospital NHSFT Laboratory Handbook 2021. NHS Foundation Trust. Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629–637. (PMID: 10.1681/ASN.2008030287191583562653687) Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM, Subcommittee on screening and management of high blood pressure in children (2017) Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Pediatrics 140:e20171904. (PMID: 10.1542/peds.2017-190428827377) De Mutiis C, Wenderfer SE, Orjuela A, Bagga A, Basu B, Sar T, Aggarwal A, Jain A, Yap HK, Ito S, Ohnishi A, Iwata N, Kasapcopur O, Laurent A, Mastrangelo A, Ogura M, Shima Y, Rianthavorn P, Silva CA, Trindade V, Dormi A, Tullus K (2022) Defining renal remission in an international cohort of 248 children and adolescents with lupus nephritis. Rheumatology (Oxford) 61:2563–2571. (PMID: 10.1093/rheumatology/keab74634626102) World Bank (2021) Data: Country Classification, Low-Income Countries. World Bank Country and Lending Groups. https://datahelpdesk.worldbank.org/knowledgebase/articles/906519 . Accessed 12 Dec 2021. Rianthavorn P, Buddhasri A (2015) Long-term renal outcomes of childhood-onset global and segmental diffuse proliferative lupus nephritis. Pediatr Nephrol 30:1969–1976. (PMID: 10.1007/s00467-015-3138-y26054714) Askenazi D, Myones B, Kamdar A, Warren R, Perez M, De Guzman M, Minta A, Hicks MJ, Kale A (2007) Outcomes of children with proliferative lupus nephritis: the role of protocol renal biopsy. Pediatr Nephrol 22:981–986. (PMID: 10.1007/s00467-007-0447-917334789) Smith E, Al-Abadi E, Armon K, Bailey K, Ciurtin C, Davidson J, Gardner-Medwin J, Haslam K, Hawley D, Leahy A, Leone V, McErlane F, Mewar D, Modgil G, Moots R, Pilkington C, Ramanan A, Rangaraj S, Riley P, Sridhar A, Wilkinson N, Beresford MW, Hedrich CM (2019) Outcomes following mycophenolate mofetil versus cyclophosphamide induction treatment for proliferative juvenile-onset lupus nephritis. Lupus 28:613–620. (PMID: 10.1177/096120331983671230871425) Pereira M, Muscal E, Eldin K, Hicks MJ, Sagcal-Gironella ACP, DeGuzman M, Wenderfer SE (2017) Clinical presentation and outcomes of childhood-onset membranous lupus nephritis. Pediatr Nephrol 32:2283–2291. (PMID: 10.1007/s00467-017-3743-z28717937) Davidson JE, Fu Q, Ji B, Rao S, Roth D, Magder LS, Petri M (2018) Renal Remission Status and Longterm Renal Survival in Patients with Lupus Nephritis: A Retrospective Cohort Analysis. J Rheumatol 45:671–677. (PMID: 10.3899/jrheum.161554294968925932209) Hanly JG, O’Keeffe AG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin P, Gladman DD, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcón GS, Fessler BJ, Steinsson K, Nived O, Sturfelt GK, Manzi S, Khamashta MA, van Vollenhoven RF, Zoma AA, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Stoll T, Inanc M, Kalunian KC, Kamen DL, Maddison P, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V (2016) The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology 55:252–262. (PMID: 10.1093/rheumatology/kev31126342222) Chan TM, Li FK, Tang CS, Wong RW, Fang GX, Ji YL, Lau CS, Wong AK, Tong MK, Chan KW, Lai KN (2000) Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. N Engl J Med 343:1156–1162. (PMID: 10.1056/NEJM20001019343160411036121) Appel GB, Contreras G, Dooley MA, Ginzler EM, Isenberg D, Jayne D, Li LS, Mysler E, Sánchez-Guerrero J, Solomons N, Wofsy D (2009) Aspreva Lupus Management Study Group. Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. J Am Soc Nephrol 20:1103–1112. (PMID: 10.1681/ASN.2008101028193694042678035) Rijnink EC, Teng YKO, Wilhelmus S, Almekinders M, Wolterbeek R, Cransberg K, Bruijn JA, Bajema IM (2017) Clinical and Histopathologic Characteristics Associated with Renal Outcomes in Lupus Nephritis. Clin J Am Soc Nephrol 12:734–743. (PMID: 10.2215/CJN.10601016284733175477219) Houssiau FA, Vasconcelos C, D’Cruz D, Sebastiani GD, de Ramon GE, Danieli MG, Abramovicz D, Blockmans D, Mathieu A, Direskeneli H, Galeazzi M, Gül A, Levy Y, Petera P, Popovic R, Petrovic R, Sinico RA, Cattaneo R, Font J, Depresseux G, Cosyns JP, Cervera R (2004) Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: lessons from long term follow-up of patients in the Euro-Lupus Nephritis Trial. Arthritis Rheum 50:3934–3940. (PMID: 10.1002/art.2066615593207) Contreras G, Pardo V, Cely C, Borja E, Hurtado A, De La Cuesta C, Iqbal K, Lenz O, Asif A, Nahar N, Leclerq B, Leon C, Schulman I, Ramirez-Seijas F, Paredes A, Cepero A, Khan T, Pachon F, Tozman E, Barreto G, Hoffman D, Almeida Suarez M, Busse JC, Esquenazi M, Esquenazi A, Garcia Mayol L, Garcia Estrada H (2005) Factors associated with poor outcomes in patients with lupus nephritis. Lupus 14:890–895. (PMID: 10.1191/0961203305lu2238oa16335581) Shaharir SS, Mustafar R, Mohd R, Mohd Said MS, Gafor HA (2015) Persistent hypertension in lupus nephritis and the associated risk factors. Clin Rheumatol 34:93–97. (PMID: 10.1007/s10067-014-2802-025373448) Feldman CH, Broder A, Guan H, Yazdany J, Costenbader KH (2018) Sex Differences in Healthcare Utilization, End-stage Renal Disease and Mortality among Medicaid Beneficiaries with Incident Lupus Nephritis. Arthritis Rheumatol 70:417–426. (PMID: 10.1002/art.40392291938935826885) Moroni G, Radice A, Giammarresi G, Quaglini S, Gallelli B, Leoni A, Li Vecchi M, Messa P, Sinico RA (2009) Are laboratory tests useful for monitoring the activity of lupus nephritis? A 6-year prospective study in a cohort of 228 patients with lupus nephritis. Ann Rheum Dis 68:234–237. (PMID: 10.1136/ard.2008.09450818718989) Esdaile JM, Joseph L, Abrahamowicz M, Li Y, Danoff D, Clarke AE (1996) Routine immunologic tests in systemic lupus erythematosus: is there a need for more studies? J Rheumatol 23:1891–1896. (PMID: 8923362) Mannemuddhu SS, Shoemaker LR, Bozorgmehri S, Borgia RE, Gupta N, Clapp WL, Zeng X, Modica RF (2023) Does kidney biopsy in pediatric lupus patients “complement” the management and outcomes of silent lupus nephritis? Lessons learned from a pediatric cohort. Pediatr Nephrol. https://doi.org/10.1007/s00467-022-05859-w. (PMID: 10.1007/s00467-022-05859-w3668894310393877) |
| فهرسة مساهمة: | Keywords: Children; Induction treatment; Kidney outcome; Lupus nephritis |
| المشرفين على المادة: | 8N3DW7272P (Cyclophosphamide) 0 (Immunosuppressive Agents) HU9DX48N0T (Mycophenolic Acid) |
| تواريخ الأحداث: | Date Created: 20230523 Date Completed: 20230922 Latest Revision: 20231201 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00467-023-06018-5 |
| PMID: | 37221349 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-198X |
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| DOI: | 10.1007/s00467-023-06018-5 |