دورية أكاديمية
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
| العنوان: | Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
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| المؤلفون: | Filgueiras PS; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Patologia, Belo Horizonte, MG, Brasil., Corsini CA; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Almeida NBF; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade da Geórgia, Faculdade de Medicina Veterinária, Departamento de Doenças Infecciosas, Athens, GA, Estados Unidos da América., Pedrosa MLC; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Miranda DAP; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Gomes SVC; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Assis JV; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Patologia, Belo Horizonte, MG, Brasil., Silva RA; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Medeiros MIVARC; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Lourenço AJ; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Bicalho CMF; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Vilela RVR; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Jeremias WJ; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Ouro Preto, Departamento de Farmácia, Ouro Preto, MG, Brasil., Fernandes GDR; Fundação Oswaldo Cruz, Instituto René Rachou, Informática de Biossistemas, Belo Horizonte, MG, Brasil., Queiroz RFGE; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Patologia, Belo Horizonte, MG, Brasil.; Universidade da Geórgia, Faculdade de Medicina Veterinária, Departamento de Doenças Infecciosas, Athens, GA, Estados Unidos da América. |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2023 May 22; Vol. 56, pp. e01672022. Date of Electronic Publication: 2023 May 22 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1997-> : Uberaba, MG, Brazil : Sociedade Brasileira de Medicina Tropical Original Publication: Rio De Janeiro : Sociedade Brasileira De Medicina Tropical |
| مواضيع طبية MeSH: | COVID-19*, Humans ; COVID-19 Testing ; SARS-CoV-2 ; Self-Testing ; Biological Assay |
| مستخلص: | Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen-detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control. |
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| تواريخ الأحداث: | Date Created: 20230524 Date Completed: 20230525 Latest Revision: 20230527 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10204152 |
| DOI: | 10.1590/0037-8682-0167-2022 |
| PMID: | 37222349 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-9849 |
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| DOI: | 10.1590/0037-8682-0167-2022 |