دورية أكاديمية
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
العنوان: | Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
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المؤلفون: | Filgueiras PS; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Patologia, Belo Horizonte, MG, Brasil., Corsini CA; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Almeida NBF; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade da Geórgia, Faculdade de Medicina Veterinária, Departamento de Doenças Infecciosas, Athens, GA, Estados Unidos da América., Pedrosa MLC; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Miranda DAP; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Gomes SVC; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil., Assis JV; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Patologia, Belo Horizonte, MG, Brasil., Silva RA; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Medeiros MIVARC; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Lourenço AJ; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Bicalho CMF; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Vilela RVR; Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil., Jeremias WJ; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Ouro Preto, Departamento de Farmácia, Ouro Preto, MG, Brasil., Fernandes GDR; Fundação Oswaldo Cruz, Instituto René Rachou, Informática de Biossistemas, Belo Horizonte, MG, Brasil., Queiroz RFGE; Fundação Oswaldo Cruz, Instituto René Rachou, Diagnóstico e Terapia de Doenças Infecciosas e Câncer, Belo Horizonte, MG, Brasil.; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Patologia, Belo Horizonte, MG, Brasil.; Universidade da Geórgia, Faculdade de Medicina Veterinária, Departamento de Doenças Infecciosas, Athens, GA, Estados Unidos da América. |
المصدر: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2023 May 22; Vol. 56, pp. e01672022. Date of Electronic Publication: 2023 May 22 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <1997-> : Uberaba, MG, Brazil : Sociedade Brasileira de Medicina Tropical Original Publication: Rio De Janeiro : Sociedade Brasileira De Medicina Tropical |
مواضيع طبية MeSH: | COVID-19*, Humans ; COVID-19 Testing ; SARS-CoV-2 ; Self-Testing ; Biological Assay |
مستخلص: | Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen-detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control. |
References: | Clin Microbiol Infect. 2019 Mar;25(3):372-378. (PMID: 29906597) Infect Dis (Lond). 2021 Jan;53(1):31-37. (PMID: 32935628) Am J Health Promot. 2022 Jan;36(1):185-189. (PMID: 34284644) Eur Phys J Plus. 2022;137(1):1. (PMID: 34909366) Clin Microbiol Infect. 2021 Feb;27(2):285.e1-285.e4. (PMID: 32422408) J Intern Med. 2020 Aug;288(2):192-206. (PMID: 32348588) J Clin Virol. 2020 Aug;129:104455. (PMID: 32485618) Ann Intern Med. 2020 Aug 18;173(4):262-267. (PMID: 32422057) J Med Virol. 2020 Jun;92(6):577-583. (PMID: 32162702) Clin Infect Dis. 2020 Jul 28;71(15):841-843. (PMID: 32047895) Sci Data. 2020 Oct 8;7(1):345. (PMID: 33033256) J Dent Res. 2020 Jul;99(8):989. (PMID: 32271653) Clin Chem Lab Med. 2020 Jun 25;58(7):1070-1076. (PMID: 32172228) Diabetes Metab Syndr. 2020 Jul - Aug;14(4):277-281. (PMID: 32283498) Clin Chem. 2009 Apr;55(4):611-22. (PMID: 19246619) Health Aff (Millwood). 2020 Jun;39(6):927-935. (PMID: 32324428) Vaccine. 2007 Jun 28;25(27):5086-96. (PMID: 17544181) Cochrane Database Syst Rev. 2021 Mar 24;3:CD013705. (PMID: 33760236) Sci Rep. 2021 Jul 20;11(1):14817. (PMID: 34285290) Expert Rev Mol Diagn. 2020 May;20(5):453-454. (PMID: 32297805) J Clin Virol. 2020 Aug;129:104500. (PMID: 32585619) Clin Infect Dis. 2020 Jul 28;71(15):778-785. (PMID: 32198501) mBio. 2020 Mar 26;11(2):. (PMID: 32217609) Int J Infect Dis. 2020 Dec;101:382-390. (PMID: 33039612) Sci China Life Sci. 2020 May;63(5):706-711. (PMID: 32146694) Eur Respir J. 2021 Apr 15;57(4):. (PMID: 33303544) J Med Virol. 2020 Jun;92(6):538-539. (PMID: 32096564) Int J Infect Dis. 2020 Oct;99:397-402. (PMID: 32800855) Clin Infect Dis. 2004 Dec 1;39(11):1572-80. (PMID: 15578353) Braz J Infect Dis. 2021 Jul-Aug;25(4):101609. (PMID: 34454894) Lancet Infect Dis. 2020 May;20(5):565-574. (PMID: 32213337) Lancet Respir Med. 2022 Nov;10(11):1061-1073. (PMID: 35988572) J Infect. 2020 Jun;80(6):e14-e18. (PMID: 32171866) J Med Virol. 2020 Jul;92(7):833-840. (PMID: 32243607) Biometrics. 1977 Mar;33(1):159-74. (PMID: 843571) J Gen Intern Med. 2020 Sep;35(9):2807-2809. (PMID: 32607935) Chin Med J (Engl). 2020 May 5;133(9):1039-1043. (PMID: 32118639) J Mol Diagn. 2022 Feb;24(2):112-119. (PMID: 34826637) JAMA. 2020 Apr 21;323(15):1502-1503. (PMID: 32105304) |
تواريخ الأحداث: | Date Created: 20230524 Date Completed: 20230525 Latest Revision: 20230527 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10204152 |
DOI: | 10.1590/0037-8682-0167-2022 |
PMID: | 37222349 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1678-9849 |
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DOI: | 10.1590/0037-8682-0167-2022 |