دورية أكاديمية
Facts and Hopes: Immunocytokines for Cancer Immunotherapy.
| العنوان: | Facts and Hopes: Immunocytokines for Cancer Immunotherapy. |
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| المؤلفون: | Pabani A; Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Gainor JF; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Oct 02; Vol. 29 (19), pp. 3841-3849. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Denville, NJ : The Association, c1995- |
| مواضيع طبية MeSH: | Antibodies, Monoclonal*/therapeutic use , Neoplasms*/drug therapy, Humans ; Cytokines ; Drug Delivery Systems ; Immunotherapy ; Tumor Microenvironment |
| مستخلص: | The clinical development of cytokines as cancer therapeutics has been limited due to significant toxicities generally observed with systemic administration. This narrow therapeutic window, together with relatively modest efficacy, has made natural cytokines unattractive drug candidates. Immunocytokines represent a class of next-generation cytokines designed to overcome the challenges associated with traditional cytokines. These agents seek to improve the therapeutic index of cytokines by using antibodies as vehicles for the targeted delivery of immunomodulatory agents within the local tumor microenvironment (TME). Various molecular formats and cytokine payloads have been studied. In this review, we provide an overview of the rationale, preclinical support, and current clinical development strategies for immunocytokines. (©2023 American Association for Cancer Research.) |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20230525 Date Completed: 20231023 Latest Revision: 20231107 |
| رمز التحديث: | 20240514 |
| DOI: | 10.1158/1078-0432.CCR-22-1837 |
| PMID: | 37227449 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-3265 |
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| DOI: | 10.1158/1078-0432.CCR-22-1837 |