دورية أكاديمية
The Comparison of Age-related Change in Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses between Glaucoma Suspects and Healthy Individuals.
| العنوان: | The Comparison of Age-related Change in Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses between Glaucoma Suspects and Healthy Individuals. |
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| المؤلفون: | Firatli G; Department of Ophthalmology, School of Medicine, Acibadem University, Istanbul, Turkey., Elibol A; Department of Ophthalmology, School of Medicine, Acibadem University, Istanbul, Turkey., Altinbas E; Department of Ophthalmology, School of Medicine, Acibadem University, Istanbul, Turkey., Ayhan C; Department of Ophthalmology, School of Medicine, Acibadem University, Istanbul, Turkey., Celebi ARC; Department of Ophthalmology, School of Medicine, Acibadem University, Istanbul, Turkey. |
| المصدر: | Journal of current glaucoma practice [J Curr Glaucoma Pract] 2023 Jan-Mar; Vol. 17 (1), pp. 22-29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Jaypee Country of Publication: India NLM ID: 101492611 Publication Model: Print Cited Medium: Print ISSN: 0974-0333 (Print) Linking ISSN: 09740333 NLM ISO Abbreviation: J Curr Glaucoma Pract Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: New Delhi : Jaypee |
| مستخلص: | Aim: The purpose of this study is to investigate the difference of change in the retinal nerve fiber layer (RNFL) and the ganglion cell complex (GCC) thickness according to age in glaucoma suspect individuals and healthy subjects. Materials and Methods: Thicknesses of RNFL and GCC were measured with spectral domain optical coherence tomography (SD-OCT) in glaucoma-suspected individuals and healthy subjects. The differences in age, overall mean, four quadrants, and 12 clock-hour sectors of RNFL and overall mean, superior half, and inferior half GCC thicknesses between glaucoma suspects and healthy participants were analyzed and compared using linear regression analyses. Results: There were 201 glaucoma-suspect individuals and 121 healthy subjects with a mean age of 38.89 and 40.26 years, respectively ( p = 0.27). The mean overall RNFL thickness was found to be 97.76 and 97.43 µm in healthy individuals and glaucoma suspects ( p = 0.72). The mean overall GCC thickness was found to be 111.30 and 104.67 µm in healthy individuals and glaucoma suspects, respectively ( p < 0.001). There was a 0.11 µm decrease per year found in overall GCC thickness in glaucoma suspects and 0.23 µm decreases per year in overall GCC thickness in healthy individuals ( p < 0.001). There was a 0.02 µm decrease per year found in overall RNFL thickness in glaucoma suspects and a 0.29 µm decrease per year in overall RNFL thickness in healthy individuals ( p < 0.001). However, these per-year decreases in GCC thickness glaucoma suspects and healthy individuals were not found to be statistically significant ( p = 0.21); on the other hand, this difference for RNFL thickness was significant ( p < 0.001). Conclusion: It was found that the thicknesses of RNFL and GCC were different between glaucoma suspects and healthy individuals. However, age-related decay in the RNFL and GCC thicknesses was not uniform in healthy individuals and glaucoma suspects. Clinical Significance: It was found that the RNFL thickness and GCC thickness were lower in glaucoma suspects than in healthy controls eyes. However, an age-related decrease of RNFL and GCC thicknesses were found to be less in glaucoma suspects compared with healthy controls. How to Cite This Article: Firatli G, Elibol A, Altinbas E, et al. The Comparison of Age-related Change in Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses between Glaucoma Suspects and Healthy Individuals. J Curr Glaucoma Pract 2023;17(1):22-29. Competing Interests: Source of support: Nil Conflict of interest: None (Copyright © 2023; The Author(s).) |
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| فهرسة مساهمة: | Keywords: Case-control study; Ganglion cell complex; Glaucoma; Glaucoma suspects; Retinal nerve fiber layer; Spectral domain optical coherence tomography |
| تواريخ الأحداث: | Date Created: 20230525 Latest Revision: 20231031 |
| رمز التحديث: | 20231101 |
| مُعرف محوري في PubMed: | PMC10203334 |
| DOI: | 10.5005/jp-journals-10078-1392 |
| PMID: | 37228305 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0974-0333 |
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| DOI: | 10.5005/jp-journals-10078-1392 |