دورية أكاديمية
أعرض في EDS

Human Archaeological Dentin as Source of Polar and Less Polar Metabolites for Untargeted Metabolomic Research: The Case of Yersinia pestis .

التفاصيل البيبلوغرافية
العنوان: Human Archaeological Dentin as Source of Polar and Less Polar Metabolites for Untargeted Metabolomic Research: The Case of Yersinia pestis .
المؤلفون: Badillo-Sanchez DA; School of Archaeology and Ancient History, University of Leicester, Leicester LE1 7RH, UK., Jones DJL; Leicester Cancer Research Centre, RKCSB, University of Leicester, Leicester LE1 7RH, UK.; The Leicester van Geest MultiOmics Facility, University of Leicester, Leicester LE1 7RH, UK., Inskip SA; School of Archaeology and Ancient History, University of Leicester, Leicester LE1 7RH, UK., Scheib CL; Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge CB2 3ER, UK.; St. John's College, University of Cambridge, Cambridge CB2 1TP, UK.
المصدر: Metabolites [Metabolites] 2023 Apr 24; Vol. 13 (5). Date of Electronic Publication: 2023 Apr 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Metabolomic approaches, such as in clinical applications of living individuals, have shown potential use for solving questions regarding the past when applied to archaeological material. Here, we study for the first time the potential of this Omic approach as applied to metabolites extracted from archaeological human dentin. Dentin obtained from micro sampling the dental pulp of teeth of victims and non-victims of Yersinia pestis (plague) from a 6th century Cambridgeshire site are used to evaluate the potential use of such unique material for untargeted metabolomic studies on disease state through liquid chromatography hyphenated to high-resolution mass spectrometry (LC-HRMS). Results show that small molecules of both likely endogenous and exogenous sources are preserved for a range of polar and less polar/apolar metabolites in archaeological dentin; however, untargeted metabolomic profiles show no clear differentiation between healthy and infected individuals in the small sample analysed ( n = 20). This study discusses the potential of dentin as a source of small molecules for metabolomic assays and highlights: (1) the need for follow up research to optimise sampling protocols, (2) the requirements of studies with larger sample numbers and (3) the necessity of more databases to amplify the positive results achievable with this Omic technique in the archaeological sciences.
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معلومات مُعتمدة: 200368/Z/15/Z United Kingdom WT_ Wellcome Trust; MR/T022302/1 United Kingdom MRC_ Medical Research Council; 2000368/Z/15/Z United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: LC-HRMS; ancient metabolomics; biomolecular archaeology; disease; human dentin; plague; untargeted metabolomics
تواريخ الأحداث: Date Created: 20230526 Latest Revision: 20240306
رمز التحديث: 20240306
مُعرف محوري في PubMed: PMC10223108
DOI: 10.3390/metabo13050588
PMID: 37233629
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo13050588