دورية أكاديمية
أعرض في EDS

Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels.

التفاصيل البيبلوغرافية
العنوان: Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels.
المؤلفون: Mouton AJ; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., do Carmo JM; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., da Silva AA; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., Omoto ACM; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., Hall JE; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States.
المصدر: Frontiers in physiology [Front Physiol] 2023 Apr 28; Vol. 14, pp. 1139296. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Macrophages play critical roles in mediating and resolving tissue injury as well as tissue remodeling during cardiorenal disease. Altered immunometabolism, particularly macrophage metabolism, is a critical underlying mechanism of immune dysfunction and inflammation, particularly in individuals with underlying metabolic abnormalities. In this review, we discuss the critical roles of macrophages in cardiac and renal injury and disease. We also highlight the roles of macrophage metabolism and discuss metabolic abnormalities, such as obesity and diabetes, which may impair normal macrophage metabolism and thus predispose individuals to cardiorenal inflammation and injury. As the roles of macrophage glucose and fatty acid metabolism have been extensively discussed elsewhere, we focus on the roles of alternative fuels, such as lactate and ketones, which play underappreciated roles during cardiac and renal injury and heavily influence macrophage phenotypes.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Mouton, do Carmo, da Silva, Omoto and Hall.)
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معلومات مُعتمدة: P20 GM104357 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: cardiac injury; heart; inflammation; ketone; kidney; lactate; macrophage; renal injury
تواريخ الأحداث: Date Created: 20230526 Latest Revision: 20230707
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10208225
DOI: 10.3389/fphys.2023.1139296
PMID: 37234412
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2023.1139296