دورية أكاديمية
Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels.
العنوان: | Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels. |
---|---|
المؤلفون: | Mouton AJ; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., do Carmo JM; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., da Silva AA; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., Omoto ACM; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States., Hall JE; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, United States. |
المصدر: | Frontiers in physiology [Front Physiol] 2023 Apr 28; Vol. 14, pp. 1139296. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
مستخلص: | Macrophages play critical roles in mediating and resolving tissue injury as well as tissue remodeling during cardiorenal disease. Altered immunometabolism, particularly macrophage metabolism, is a critical underlying mechanism of immune dysfunction and inflammation, particularly in individuals with underlying metabolic abnormalities. In this review, we discuss the critical roles of macrophages in cardiac and renal injury and disease. We also highlight the roles of macrophage metabolism and discuss metabolic abnormalities, such as obesity and diabetes, which may impair normal macrophage metabolism and thus predispose individuals to cardiorenal inflammation and injury. As the roles of macrophage glucose and fatty acid metabolism have been extensively discussed elsewhere, we focus on the roles of alternative fuels, such as lactate and ketones, which play underappreciated roles during cardiac and renal injury and heavily influence macrophage phenotypes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Mouton, do Carmo, da Silva, Omoto and Hall.) |
References: | Circ Heart Fail. 2020 Aug;13(8):e006414. (PMID: 32809874) Front Physiol. 2021 Oct 18;12:688485. (PMID: 34733170) Nutrients. 2016 Mar 02;8(3):128. (PMID: 26950145) Oncogene. 2014 Jul 31;33(31):4060-8. (PMID: 24166504) Circ Res. 2021 Dec 3;129(12):1086-1101. (PMID: 34645281) JCI Insight. 2019 Feb 21;4(4):. (PMID: 30668551) JCI Insight. 2019 Apr 23;5:. (PMID: 31012869) Cardiovasc Diabetol. 2019 Jan 29;18(1):13. (PMID: 30696455) Nat Rev Nephrol. 2019 Jun;15(6):367-385. (PMID: 31015582) Basic Res Cardiol. 2018 Jun 4;113(4):26. (PMID: 29868933) Cell Rep. 2020 Sep 1;32(9):108087. (PMID: 32877669) Contrib Nephrol. 2011;170:28-35. (PMID: 21659755) Transl Res. 2022 Nov;249:88-109. (PMID: 35788054) J Neuroimmune Pharmacol. 2015 Sep;10(3):468-76. (PMID: 25870122) Front Immunol. 2021 Jun 03;12:618501. (PMID: 34149684) Arterioscler Thromb Vasc Biol. 2015 May;35(5):1066-70. (PMID: 25792449) Circulation. 2000 Jun 27;101(25):2981-8. (PMID: 10869273) Brain Res. 2000 Feb 7;855(1):192-7. (PMID: 10650150) Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec;1865(12):158813. (PMID: 32920139) J Physiol Sci. 2022 Jun 20;72(1):12. (PMID: 35725377) Hypertension. 2019 Nov;74(5):1113-1123. (PMID: 31542966) Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F544-F548. (PMID: 31984790) Front Immunol. 2021 Oct 19;12:732913. (PMID: 34737743) Int J Clin Exp Pathol. 2012;5(7):651-9. (PMID: 22977661) Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1409-F1413. (PMID: 31566432) J Exp Med. 2018 Feb 5;215(2):423-440. (PMID: 29339450) Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F689-F701. (PMID: 31928224) Int J Mol Sci. 2020 Jul 31;21(15):. (PMID: 32752107) Circ Res. 2014 Jul 7;115(2):284-95. (PMID: 24786973) Sci Rep. 2019 Aug 7;9(1):11447. (PMID: 31391499) Front Physiol. 2021 Jun 30;12:689747. (PMID: 34276410) J Physiol. 2020 Nov;598(21):4869-4885. (PMID: 32735362) Circ Res. 2022 Mar 4;130(5):779-781. (PMID: 35170337) Trends Mol Med. 2019 Apr;25(4):328-340. (PMID: 30737012) Front Cardiovasc Med. 2019 Apr 11;6:42. (PMID: 31032261) Am J Med Sci. 2014 Oct;348(4):315-8. (PMID: 24642654) Front Immunol. 2021 Jul 29;12:691134. (PMID: 34394085) J Physiol Sci. 2020 Feb 17;70(1):11. (PMID: 32066375) Am J Physiol Heart Circ Physiol. 2022 May 1;322(5):H749-H761. (PMID: 35275762) Metab Syndr Relat Disord. 2019 Jun;17(5):259-265. (PMID: 30864887) Am J Physiol Renal Physiol. 2020 Jul 1;319(1):F106-F114. (PMID: 32508113) Mol Med. 2022 Aug 12;28(1):95. (PMID: 35962319) JACC Basic Transl Sci. 2021 Jan 25;6(1):55-70. (PMID: 33532666) Endocr J. 2010;57(1):61-72. (PMID: 19851035) Int J Mol Sci. 2022 Aug 17;23(16):. (PMID: 36012516) Mediators Inflamm. 2021 Mar 30;2021:5597118. (PMID: 33859538) Eur J Heart Fail. 2019 Jul;21(7):862-873. (PMID: 31033127) Cell Metab. 2020 Sep 1;32(3):404-419.e6. (PMID: 32726607) Nutrients. 2019 Sep 04;11(9):. (PMID: 31487814) Metabolism. 1992 Jan;41(1):22-7. (PMID: 1538640) Cardiovasc Res. 2020 May 1;116(6):1101-1112. (PMID: 31841135) Cell Metab. 2020 May 5;31(5):909-919.e8. (PMID: 32275862) J Lipid Atheroscler. 2022 Jan;11(1):1-19. (PMID: 35118019) Front Immunol. 2020 Jan 10;10:2993. (PMID: 31998297) J Immunol. 2015 Jun 15;194(12):6082-9. (PMID: 25964487) Cardiovasc Res. 1999 Jul;43(1):96-106. (PMID: 10536694) Front Physiol. 2022 Jul 04;13:946474. (PMID: 35860662) Front Physiol. 2022 Sep 08;13:927078. (PMID: 36160854) Diabetes Care. 2003 Nov;26(11):3129-35. (PMID: 14578250) Nat Rev Nephrol. 2022 Sep;18(9):588-603. (PMID: 35798902) Cell Metab. 2019 Feb 5;29(2):383-398.e7. (PMID: 30449686) Circulation. 2019 Apr 30;139(18):2129-2141. (PMID: 30884964) Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15160-15171. (PMID: 32541026) Front Immunol. 2019 Jul 03;10:1462. (PMID: 31333642) Front Med (Lausanne). 2021 Nov 29;8:744122. (PMID: 34912819) Cell Metab. 2019 Feb 5;29(2):443-456.e5. (PMID: 30595481) Cell Metab. 2020 Jun 2;31(6):1136-1153.e7. (PMID: 32492393) Cells. 2019 Sep 18;8(9):. (PMID: 31540443) Mol Biol Rep. 2022 Oct;49(10):9749-9758. (PMID: 35441940) Life Sci. 2022 Jan 15;289:120227. (PMID: 34921866) Nat Med. 2015 Mar;21(3):263-9. (PMID: 25686106) Adv Nutr. 2019 Mar 1;10(2):321-330. (PMID: 30753258) Nat Cardiovasc Res. 2022 Mar;1(3):211-222. (PMID: 35755006) Crit Care. 2014 Mar 25;18(2):R48. (PMID: 24666826) Curr Hypertens Rep. 2020 Feb 3;22(2):15. (PMID: 32016622) Aging (Albany NY). 2019 Jul 29;11(14):5258-5275. (PMID: 31386629) Pediatr Nephrol. 2019 Apr;34(4):561-569. (PMID: 29383444) PLoS One. 2014 Nov 21;9(11):e112710. (PMID: 25415601) Front Nutr. 2020 Feb 19;7:13. (PMID: 32140471) J Mol Cell Cardiol. 2021 Sep;158:38-48. (PMID: 34023353) JACC Basic Transl Sci. 2018 Mar 14;3(2):230-244. (PMID: 30062209) Circ Res. 2021 May 14;128(10):1451-1467. (PMID: 33983831) PLoS One. 2018 Mar 8;13(3):e0194053. (PMID: 29518138) Circ Res. 2016 Sep 16;119(7):853-64. (PMID: 27444755) Cell Commun Signal. 2022 Jul 27;20(1):114. (PMID: 35897036) Circ Res. 2019 Jan 18;124(2):263-278. (PMID: 30582448) Antioxid Redox Signal. 2018 Jul 20;29(3):297-312. (PMID: 28661198) Nephrol Dial Transplant. 2020 Nov 1;35(11):1840-1852. (PMID: 33151338) Crit Care. 2002 Aug;6(4):322-6. (PMID: 12225607) Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):580-585. (PMID: 28049847) Sci Adv. 2021 Nov 12;7(46):eabi8602. (PMID: 34767443) J Am Heart Assoc. 2017 Feb 27;6(3):. (PMID: 28242634) Physiology (Bethesda). 2015 May;30(3):183-94. (PMID: 25933819) J Clin Invest. 2021 Nov 1;131(21):. (PMID: 34491913) Circulation. 2020 Jun 2;141(22):1800-1812. (PMID: 32479196) BMC Immunol. 2018 Jul 11;19(1):24. (PMID: 29996768) Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4661-E4669. (PMID: 29712858) Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F561-F575. (PMID: 28228400) Nat Commun. 2014 May 21;5:3944. (PMID: 24845831) J Am Heart Assoc. 2019 Sep 3;8(17):e013114. (PMID: 31431116) Am J Nephrol. 2021;52(6):467-478. (PMID: 34350876) Front Cardiovasc Med. 2021 Dec 07;8:789458. (PMID: 34950719) Ann Rheum Dis. 2018 Aug;77(8):1226-1233. (PMID: 29724730) Heliyon. 2018 Nov 24;4(11):e00975. (PMID: 30533548) Circ Res. 2020 Mar 13;126(6):789-806. (PMID: 32163341) Curr Opin Nephrol Hypertens. 2020 May;29(3):286-292. (PMID: 32235271) Front Endocrinol (Lausanne). 2016 Dec 12;7:157. (PMID: 28018292) Am J Physiol Regul Integr Comp Physiol. 2020 Oct 1;319(4):R476-R484. (PMID: 32877243) JACC Basic Transl Sci. 2022 Nov 30;8(2):174-185. (PMID: 36908663) Kidney Int. 2019 May;95(5):1120-1137. (PMID: 30826015) Nat Commun. 2022 Oct 10;13(1):5974. (PMID: 36216803) J Mol Cell Cardiol. 2007 Jan;42(1):177-85. (PMID: 17069847) Nutr Rev. 2022 Mar 10;80(4):774-785. (PMID: 34957519) mBio. 2022 Aug 30;13(4):e0127422. (PMID: 35762591) Int Rev Immunol. 2022;41(1):4-18. (PMID: 34304685) Front Immunol. 2020 Oct 06;11:587913. (PMID: 33123172) Cell Rep. 2017 Aug 15;20(7):1654-1666. (PMID: 28813676) Front Endocrinol (Lausanne). 2020 Feb 19;11:62. (PMID: 32140136) Cardiovasc Res. 2021 Jul 7;117(8):1859-1876. (PMID: 33258945) J Clin Invest. 2016 May 2;126(5):1939-52. (PMID: 27088805) Nat Commun. 2022 Sep 5;13(1):5208. (PMID: 36064857) J Cell Mol Med. 2020 Feb;24(4):2593-2609. (PMID: 31930778) Metabolism. 2005 Nov;54(11):1542-5. (PMID: 16253646) Nature. 2012 Nov 15;491(7424):357-63. (PMID: 23151578) Nat Commun. 2020 May 1;11(1):2127. (PMID: 32358544) Cardiovasc Res. 2021 Apr 23;117(5):1358-1371. (PMID: 33038226) Nat Immunol. 2017 Sep;18(9):985-994. (PMID: 28714978) Circ Heart Fail. 2021 Jan;14(1):e007684. (PMID: 33356362) Immunother Adv. 2022 Jun 01;2(1):ltac010. (PMID: 36284839) Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165739. (PMID: 32084511) Diabetes. 2022 Apr 1;71(4):637-652. (PMID: 35044451) Nat Rev Nephrol. 2021 Jul;17(7):465-480. (PMID: 33828286) Front Med (Lausanne). 2021 Jul 08;8:688060. (PMID: 34307414) J Exp Med. 2021 Sep 6;218(9):. (PMID: 34325467) Inflamm Res. 2020 Dec;69(12):1215-1234. (PMID: 33044562) Front Immunol. 2022 Nov 02;13:1015142. (PMID: 36405700) J Clin Invest. 2021 Jun 15;131(12):. (PMID: 33956666) Cell Metab. 2017 Feb 7;25(2):262-284. (PMID: 28178565) Sci Rep. 2020 Mar 27;10(1):5555. (PMID: 32221369) Diabetes Obes Metab. 2020 Apr;22 Suppl 1:16-31. (PMID: 32267077) Cardiovasc Diabetol. 2021 Feb 2;20(1):33. (PMID: 33530978) Am J Physiol Regul Integr Comp Physiol. 2017 Nov 1;313(5):R572-R582. (PMID: 28768659) Sci Rep. 2021 Aug 19;11(1):16801. (PMID: 34413352) Cell Rep. 2018 Oct 16;25(3):677-689.e4. (PMID: 30332647) Biomed Res Int. 2015;2015:732450. (PMID: 26114112) Tomography. 2019 Jun;5(2):239-247. (PMID: 31245545) Front Physiol. 2021 Aug 17;12:715081. (PMID: 34483967) Immunology. 2018 Jul;154(3):346-353. (PMID: 29465812) J Clin Med. 2020 Jan 23;9(2):. (PMID: 31979327) Front Physiol. 2021 Jun 21;12:694864. (PMID: 34234695) J Clin Invest. 2021 Mar 15;131(6):. (PMID: 33529176) Proc Nutr Soc. 1995 Mar;54(1):197-212. (PMID: 7568254) Cardiovasc Diabetol. 2019 Aug 7;18(1):100. (PMID: 31391045) Front Immunol. 2022 Oct 18;13:1013686. (PMID: 36330516) J Am Heart Assoc. 2020 Aug 4;9(15):e013039. (PMID: 32750298) JAMA. 2018 Jan 16;319(3):215-217. (PMID: 29340675) Kardiol Pol. 2013;71(3):260-7. (PMID: 23575781) Semin Nephrol. 2018 Mar;38(2):111-120. (PMID: 29602394) Nat Immunol. 2019 Jan;20(1):29-39. (PMID: 30538339) Sci Adv. 2022 Apr 29;8(17):eabm8965. (PMID: 35476437) BMC Pharmacol Toxicol. 2020 Oct 1;21(1):71. (PMID: 33004081) Front Cell Dev Biol. 2022 Aug 26;10:972020. (PMID: 36092712) BMC Med. 2022 Apr 15;20(1):148. (PMID: 35422042) Obesity (Silver Spring). 2018 Apr;26(4):683-688. (PMID: 29476613) Nature. 2019 Oct;574(7779):575-580. (PMID: 31645732) Am J Physiol Cell Physiol. 2021 Feb 1;320(2):C155-C161. (PMID: 33264077) Cardiovasc Ther. 2021 Jun 05;2021:5530541. (PMID: 34194542) J Am Heart Assoc. 2022 Nov;11(21):e027081. (PMID: 36300667) Biochem Biophys Res Commun. 2017 Aug 26;490(3):1080-1085. (PMID: 28668396) Pflugers Arch. 2017 Apr;469(3-4):419-430. (PMID: 28251313) Can J Cardiol. 2020 May;36(5):671-682. (PMID: 32389340) Cell Death Differ. 2022 Jan;29(1):133-146. (PMID: 34363018) Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2289-94. (PMID: 11709394) J Neurosci. 2010 Apr 28;30(17):6036-47. (PMID: 20427662) Front Immunol. 2022 Jul 13;13:934299. (PMID: 35911736) Clin Exp Nephrol. 2021 Sep;25(9):915-924. (PMID: 33877485) Curr Heart Fail Rep. 2011 Dec;8(4):242-51. (PMID: 21842146) Transl Res. 2018 Jan;191:15-28. (PMID: 29106912) J Am Coll Cardiol. 2013 Jul 23;62(4):263-71. (PMID: 23684677) Circ Res. 2022 Nov 11;131(11):893-908. (PMID: 36268709) Intensive Care Med. 2009 Mar;35(3):471-9. (PMID: 18807008) Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6254-E6263. (PMID: 29891687) Cell Rep. 2021 Dec 28;37(13):110171. (PMID: 34965415) Nutrients. 2022 Mar 22;14(7):. (PMID: 35405935) Ann Intensive Care. 2018 Feb 14;8(1):24. (PMID: 29445877) Front Nutr. 2021 Apr 22;8:663560. (PMID: 33968972) Biochem Biophys Res Commun. 2021 Oct 8;573:13-18. (PMID: 34375764) J Biol Chem. 2020 Jan 3;295(1):83-98. (PMID: 31690627) Metabolism. 2017 Dec;77:65-72. (PMID: 29132539) Circ Res. 2018 Apr 13;122(8):1084-1093. (PMID: 29440071) J Biol Chem. 2022 Apr;298(4):101768. (PMID: 35218776) |
معلومات مُعتمدة: | P20 GM104357 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: cardiac injury; heart; inflammation; ketone; kidney; lactate; macrophage; renal injury |
تواريخ الأحداث: | Date Created: 20230526 Latest Revision: 20230707 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10208225 |
DOI: | 10.3389/fphys.2023.1139296 |
PMID: | 37234412 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-042X |
---|---|
DOI: | 10.3389/fphys.2023.1139296 |