دورية أكاديمية
أعرض في EDS

Association of Single-Nucleotide Polymorphisms in the VDR Gene with Tuberculosis and Infection of Beijing Genotype Mycobacterium tuberculosis .

التفاصيل البيبلوغرافية
العنوان: Association of Single-Nucleotide Polymorphisms in the VDR Gene with Tuberculosis and Infection of Beijing Genotype Mycobacterium tuberculosis .
المؤلفون: Yu J; School of Public Health, University of South China, Hengyang, 421001, People's Republic of China.; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China., Liu M; School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, 830011, People's Republic of China., Mijiti X; The Eighth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830049, People's Republic of China., Liu H; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China., Wang Q; The Eighth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830049, People's Republic of China., Yin C; School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, 830011, People's Republic of China., Anwaierjiang A; College of Xinjiang Uyghur Medicine, Hetian, 848000, People's Republic of China., Xu M; The Eighth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830049, People's Republic of China., Li M; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China., Deng L; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China., Xiao H; School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, 830011, People's Republic of China., Zhao X; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China., Wan K; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China., Li G; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China., Yuan X; School of Public Health, University of South China, Hengyang, 421001, People's Republic of China.
المصدر: Infection and drug resistance [Infect Drug Resist] 2023 May 22; Vol. 16, pp. 3157-3169. Date of Electronic Publication: 2023 May 22 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101550216 Publication Model: eCollection Cited Medium: Print ISSN: 1178-6973 (Print) Linking ISSN: 11786973 NLM ISO Abbreviation: Infect Drug Resist Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Auckland, N.Z. : Dove Medical Press, 2008-
مستخلص: Background: The aim of the present study was to investigate the association between vitamin D receptor ( VDR ) gene polymorphism and tuberculosis susceptibility, as well as the potential interaction of host genetic factors with the heterogeneity of Mycobacterium tuberculosis in the population from Xinjiang, China.
Methods: From January 2019 to January 2020, we enrolled 221 tuberculosis patients as the case group and 363 staff with no clinical symptoms as the control group from four designated tuberculosis hospitals in southern Xinjiang, China. The polymorphisms of Fok I, Taq I, Apa I, Bsm I, rs3847987 and rs739837 in the VDR were detected by sequencing. M. tuberculosis isolates were collected from the case group and identified as Beijing or non-Beijing lineage by multiplex PCR. Propensity score (PS), univariate analysis and multivariable logistic regression models were used to perform the analysis.
Results: Our results showed that the allele and genotype frequencies of Fok I, Taq I, Apa I, Bsm I, rs3847987 and rs739837 in VDR were not correlated with tuberculosis susceptibility or lineages of M. tuberculosis . Two out of six loci of the VDR gene formed one haplotype block, and none of the haplotypes was found to correlate with tuberculosis susceptibility or lineages of M. tuberculosis infected.
Conclusion: Polymorphisms in the VDR gene may not indicate susceptibility to tuberculosis. There was also no evidence on the interaction between the VDR gene of host and the lineages of M. tuberculosis in the population from Xinjiang, China. Further studies are nonetheless required to prove our conclusions.
Competing Interests: We have no conflicts of interest to declare.
(© 2023 Yu et al.)
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فهرسة مساهمة: Keywords: Beijing lineage; Mycobacterium tuberculosis; VDR; polymorphism; tuberculosis; vitamin D receptor
تواريخ الأحداث: Date Created: 20230526 Latest Revision: 20230528
رمز التحديث: 20230528
مُعرف محوري في PubMed: PMC10208660
DOI: 10.2147/IDR.S407595
PMID: 37235072
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-6973
DOI:10.2147/IDR.S407595