دورية أكاديمية
أعرض في EDS

Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID.

التفاصيل البيبلوغرافية
العنوان: Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID.
المؤلفون: Neves PFMD; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil., Quaresma JAS; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil.; Tropical Medicine Center, Federal University of Pará, Belém 66055-240, Brazil.; School of Medicine, São Paulo University, São Paulo 01246-903, Brazil., Queiroz MAF; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Silva CC; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil., Maia EV; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil., Oliveira JSS; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil., Neves CMAD; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil., Mendonça SDS; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil., Falcão ASC; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil., Melo GS; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil., Santos IBF; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil., Sousa JR; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil.; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua 67030-000, Brazil., Santos EJMD; Laboratory of Genetic of Complex Discasse, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Brazil., Vasconcelos PFDC; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil.; Departamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua 67030-000, Brazil., Vallinoto ACR; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Brazil., Falcão LFM; Center for Biological Health Sciences, State University of Pará, Belém 66087-670, Brazil.; School of Medicine, São Paulo University, São Paulo 01246-903, Brazil.
المصدر: Biology [Biology (Basel)] 2023 May 19; Vol. 12 (5). Date of Electronic Publication: 2023 May 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101587988 Publication Model: Electronic Cited Medium: Print ISSN: 2079-7737 (Print) Linking ISSN: 20797737 NLM ISO Abbreviation: Biology (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2012-
مستخلص: A persistent state of inflammation has been reported during the COVID-19 pandemic. This study aimed to assess short-term heart rate variability (HRV), peripheral body temperature, and serum cytokine levels in patients with long COVID. We evaluated 202 patients with long COVID symptoms categorized them according to the duration of their COVID symptoms (≤120 days, n = 81; >120 days, n = 121), in addition to 95 healthy individuals selected as controls. All HRV variables differed significantly between the control group and patients with long COVID in the ≤120 days group ( p < 0.05), and participants in the long COVID ≤120 days group had higher temperatures than those in the long COVID >120 days group in all regions analysed ( p < 0.05). Cytokine analysis showed higher levels of interleukin 17 (IL-17) and interleukin 2 (IL-2), and lower levels of interleukin 4 (IL-4) ( p < 0.05). Our results suggest a reduction in parasympathetic activation during long COVID and an increase in body temperature due to possible endothelial damage caused by the maintenance of elevated levels of inflammatory mediators. Furthermore, high serum levels of IL-17 and IL-2 and low levels of IL-4 appear to constitute a long-term profile of COVID-19 cytokines, and these markers are potential targets for long COVID-treatment and prevention strategies.
Competing Interests: The authors declare no conflicts of interest.
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معلومات مُعتمدة: #006/2020 and #060/2020 Amazon Foundation for Research Support (FAPESPA); #09/2021 Secretary of Science, Technology, and Higher, Professional and Technological Education (SECTET); #401235/2020-3 National Council for Scientific and Technological Development; #406360/2022-7 Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brasil (INCT )
فهرسة مساهمة: Keywords: autonomic nervous system; cytokines; long COVID; thermography
تواريخ الأحداث: Date Created: 20230527 Latest Revision: 20230530
رمز التحديث: 20230530
مُعرف محوري في PubMed: PMC10215572
DOI: 10.3390/biology12050749
PMID: 37237560
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-7737
DOI:10.3390/biology12050749