دورية أكاديمية
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Retrospective Analysis of the Outcome of Hospitalized COVID-19 Patients with Coexisting Metabolic Syndrome and HIV Using Multinomial Logistic Regression.

التفاصيل البيبلوغرافية
العنوان: Retrospective Analysis of the Outcome of Hospitalized COVID-19 Patients with Coexisting Metabolic Syndrome and HIV Using Multinomial Logistic Regression.
المؤلفون: Mphekgwana PM; Research Administration and Development, University of Limpopo, Polokwane 0727, South Africa., Sono-Setati ME; Department of Public Health Medicine, University of Limpopo, Private Bag X1106, Sovenga, Polokwane 0727, South Africa., Mokgophi TV; Department of Statistics and Operations Research, University of Limpopo, Polokwane 0727, South Africa., Kifle YG; Department of Mathematics and Statistics, University of Maryland Baltimore County, Baltimore, MD 21250, USA., Madiba S; Faculty of Health Sciences, University of Limpopo, Polokwane 0727, South Africa., Modjadji P; Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town 7505, South Africa.
المصدر: International journal of environmental research and public health [Int J Environ Res Public Health] 2023 May 12; Vol. 20 (10). Date of Electronic Publication: 2023 May 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI, c2004-
مواضيع طبية MeSH: COVID-19*/epidemiology , COVID-19*/therapy , Metabolic Syndrome*/epidemiology , Diabetes Mellitus*/epidemiology , Hypertension*/epidemiology , HIV Infections*/complications , HIV Infections*/epidemiology , HIV Infections*/drug therapy, Humans ; Male ; Retrospective Studies ; Logistic Models ; Cross-Sectional Studies ; Obesity ; Hospitalization ; Risk Factors
مستخلص: Globally, the coexistence of metabolic syndrome (MetS) and HIV has become an important public health problem, putting coronavirus disease 19 (COVID-19) hospitalized patients at risk for severe manifestations and higher mortality. A retrospective cross-sectional analysis was conducted to identify factors and determine their relationships with hospitalization outcomes for COVID-19 patients using secondary data from the Department of Health in Limpopo Province, South Africa. The study included 15,151 patient clinical records of laboratory-confirmed COVID-19 cases. Data on MetS was extracted in the form of a cluster of metabolic factors. These included abdominal obesity, high blood pressure, and impaired fasting glucose captured on an information sheet. Spatial distribution of mortality among patients was observed; overall (21-33%), hypertension (32-43%), diabetes (34-47%), and HIV (31-45%). A multinomial logistic regression model was applied to identify factors and determine their relationships with hospitalization outcomes for COVID-19 patients. Mortality among COVID-19 patients was associated with being older (≥50+ years), male, and HIV positive. Having hypertension and diabetes reduced the duration from admission to death. Being transferred from a primary health facility (PHC) to a referral hospital among COVID-19 patients was associated with ventilation and less chance of being transferred to another health facility when having HIV plus MetS. Patients with MetS had a higher mortality rate within seven days of hospitalization, followed by those with obesity as an individual component. MetS and its components such as hypertension, diabetes, and obesity should be considered a composite predictor of COVID-19 fatal outcomes, mostly, increased risk of mortality. The study increases our understanding of the common contributing variables to severe manifestations and a greater mortality risk among COVID-19 hospitalized patients by investigating the influence of MetS, its components, and HIV coexistence. Prevention remains the mainstay for both communicable and non-communicable diseases. The findings underscore the need for improvement of critical care resources across South Africa.
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فهرسة مساهمة: Keywords: COVID-19; HIV; South Africa; hospitalization; metabolic syndrome; non-communicable diseases
تواريخ الأحداث: Date Created: 20230527 Date Completed: 20230529 Latest Revision: 20230627
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10218513
DOI: 10.3390/ijerph20105799
PMID: 37239527
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-4601
DOI:10.3390/ijerph20105799