دورية أكاديمية
UPLC-QE-Orbitrap-Based Cell Metabolomics and Network Pharmacology to Reveal the Mechanism of N-Benzylhexadecanamide Isolated from Maca ( Lepidium meyenii Walp.) against Testicular Dysfunction.
العنوان: | UPLC-QE-Orbitrap-Based Cell Metabolomics and Network Pharmacology to Reveal the Mechanism of N-Benzylhexadecanamide Isolated from Maca ( Lepidium meyenii Walp.) against Testicular Dysfunction. |
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المؤلفون: | Zhang KY; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Li CN; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Zhang NX; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Gao XC; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Shen JM; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Cheng DD; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Wang YL; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Zhang H; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Lv JW; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China., Sun JM; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China. |
المصدر: | Molecules (Basel, Switzerland) [Molecules] 2023 May 12; Vol. 28 (10). Date of Electronic Publication: 2023 May 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
مواضيع طبية MeSH: | Tandem Mass Spectrometry* , Lepidium*/chemistry, Mice ; Male ; Animals ; Network Pharmacology ; Hydrogen Peroxide ; Polyunsaturated Alkamides ; Testosterone ; Metabolomics |
مستخلص: | Testicular dysfunction (TDF) is characterized by testosterone deficiency and is caused by oxidative stress injury in Leydig cells. A natural fatty amide named N-benzylhexadecanamide (NBH), derived from cruciferous maca, has been shown to promote testosterone production. Our study aims to reveal the anti-TDF effect of NBH and explore its potential mechanism in vitro. This study examined the effects of H |
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معلومات مُعتمدة: | 31570347 National Natural Science Foundation of China; 2022011 Jilin Province Development and Reform Commission; 20200404081YY Jilin Province Science and Technology Department |
فهرسة مساهمة: | Keywords: N-benzylhexadecanamide; mechanisms; metabolomics; network pharmacology; testicular dysfunction |
المشرفين على المادة: | 1M5UVS8JUU (N-benzylhexadecanamide) BBX060AN9V (Hydrogen Peroxide) 0 (Polyunsaturated Alkamides) 3XMK78S47O (Testosterone) |
تواريخ الأحداث: | Date Created: 20230527 Date Completed: 20230529 Latest Revision: 20230530 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10222419 |
DOI: | 10.3390/molecules28104064 |
PMID: | 37241805 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1420-3049 |
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DOI: | 10.3390/molecules28104064 |