Purification, Structural Analysis and Cardio-Protective Activity of Polysaccharides from Radix Astragali.

التفاصيل البيبلوغرافية
العنوان:	Purification, Structural Analysis and Cardio-Protective Activity of Polysaccharides from Radix Astragali.
المؤلفون:	Wang S; College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China., Peng Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China., Zhuang Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China., Wang N; College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China., Jin J; College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China., Zhan Z; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
المصدر:	Molecules (Basel, Switzerland) [Molecules] 2023 May 18; Vol. 28 (10). Date of Electronic Publication: 2023 May 18.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH:	Drugs, Chinese Herbal/pharmacology , Drugs, Chinese Herbal/chemistry , Astragalus Plant*/chemistry, Rats ; Animals ; Polysaccharides/chemistry ; Astragalus propinquus
مستخلص:	Two polysaccharides, named APS2-I and APS3-I, were purified from the water extract of Radix Astragali. The average molecular weight of APS2-I was 1.96 × 10 ⁶ Da and composed of Man, Rha, GlcA, GalA, Glc, Gal, Xyl, and Ara in a molar ratio of 2.3:4.8:1.7:14.0:5.8:11.7:2.8:12.6, while the average molecular weight of APS3-I was 3.91 × 10 ⁶ Da and composed of Rha, GalA, Glc, Gal, and Ara in a molar ratio of 0.8:2.3:0.8:2.3:4.1. Biological evaluation showed APS2-I and APS3-I had significant antioxidant activity and myocardial protection activity. Furthermore, total polysaccharide treatment could significantly enhance hemodynamic parameters and improve cardiac function in rat ischemia and reperfusion isolated heart models. These results provided important information for the clinical application of APS in the field of cardiovascular disease and implied that Astragalus polysaccharides (APS) could be considered as a reference for the quality control of Radix Astragali.
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معلومات مُعتمدة:	LTGY23B020001 Zhejiang Provincial Natural Science Foundation of China; 82273825 the National Natural Science Foundation of China
فهرسة مساهمة:	Keywords: Astragalus membranaceus; antioxidant; cardio-protection; polysaccharide
المشرفين على المادة:	922OP8YUPF (Huang Qi) 0 (Polysaccharides) 0 (Drugs, Chinese Herbal)
تواريخ الأحداث:	Date Created: 20230527 Date Completed: 20230529 Latest Revision: 20230530
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC10222213
DOI:	10.3390/molecules28104167
PMID:	37241906
قاعدة البيانات:	MEDLINE

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تدمد:	1420-3049
DOI:	10.3390/molecules28104167