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Safety, Tolerability, and Pharmacokinetics of β-Cryptoxanthin Supplementation in Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.

التفاصيل البيبلوغرافية
العنوان: Safety, Tolerability, and Pharmacokinetics of β-Cryptoxanthin Supplementation in Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.
المؤلفون: Tan KML; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Department of Laboratory Medicine, National University Hospital, Singapore 119074, Singapore., Chee J; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore., Lim KLM; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore., Ng M; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Bioinformatics Institute, Agency for Science Technology and Research Singapore, Singapore 138671, Singapore., Gong M; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore., Xu J; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore., Tin F; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore., Natarajan P; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore., Lee BL; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore., Ong CN; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore., Tint MT; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Kee MZL; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore., Müller-Riemenschneider F; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.; Digital Health Centre, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10179 Berlin, Germany., Gluckman PD; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Liggins Institute, University of Auckland, Auckland 1023, New Zealand., Meaney MJ; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada., Kumar M; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Bioinformatics Institute, Agency for Science Technology and Research Singapore, Singapore 138671, Singapore., Karnani N; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Bioinformatics Institute, Agency for Science Technology and Research Singapore, Singapore 138671, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Eriksson JG; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Department of General Practice and Primary Health Care, University of Helsinki, 00100 Helsinki, Finland.; Folkhälsan Research Center, 00250 Helsinki, Finland., Nandanan B; DSM Nutritional Products Ltd., 4001 Basel, Switzerland., Wyss A; DSM Nutritional Products Ltd., 4001 Basel, Switzerland., Cameron-Smith D; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research Singapore, Singapore 117609, Singapore.; School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia.
المصدر: Nutrients [Nutrients] 2023 May 16; Vol. 15 (10). Date of Electronic Publication: 2023 May 16.
نوع المنشور: Randomized Controlled Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Vitamin A* , Beta-Cryptoxanthin*, Humans ; Female ; Carotenoids ; beta Carotene ; Lutein ; Zeaxanthins ; Dietary Supplements
مستخلص: Background: β-cryptoxanthin is a dietary carotenoid for which there have been few studies on the safety and pharmacokinetics following daily oral supplementation.
Methods: 90 healthy Asian women between 21 and 35 years were randomized into three groups: 3 and 6 mg/day oral β-cryptoxanthin, and placebo. At 2, 4, and 8 weeks of supplementation, plasma carotenoid levels were measured. The effects of β-cryptoxanthin on blood retinoid-dependent gene expression, mood, physical activity and sleep, metabolic parameters, and fecal microbial composition were investigated.
Results: β-cryptoxanthin supplementation for 8 weeks (3 and 6 mg/day) was found to be safe and well tolerated. Plasma β-cryptoxanthin concentration was significantly higher in the 6 mg/day group (9.0 ± 4.1 µmol/L) compared to 3 mg/day group (6.0 ± 2.6 µmol/L) ( p < 0.03), and placebo (0.4 ± 0.1 µmol/L) ( p < 0.001) after 8 weeks. Plasma all-trans retinol, α-cryptoxanthin, α-carotene, β-carotene, lycopene, lutein, and zeaxanthin levels were not significantly changed. No effects were found on blood retinol-dependent gene expression, mood, physical activity and sleep, metabolic parameters, and fecal microbial composition.
Conclusions: Oral β-cryptoxanthin supplementation over 8 weeks lead to high plasma concentrations of β-cryptoxanthin, with no impact on other carotenoids, and was well tolerated in healthy women.
References: Soc Psychiatry Psychiatr Epidemiol. 2011 Jul;46(7):635-41. (PMID: 20422399)
FASEB J. 2010 Jun;24(6):1656-66. (PMID: 20061533)
Psychiatry Res. 1989 May;28(2):193-213. (PMID: 2748771)
Nutr Rev. 2016 Feb;74(2):69-82. (PMID: 26747887)
Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
Am J Clin Nutr. 2005 Sep;82(3):685-93. (PMID: 16155284)
Food Nutr Res. 2020 Dec 28;64:. (PMID: 33447180)
Biol Pharm Bull. 2019;42(8):1402-1408. (PMID: 31366875)
Am J Clin Nutr. 2013 Nov;98(5):1200-8. (PMID: 24004891)
Mech Ageing Dev. 2007 Nov-Dec;128(11-12):594-600. (PMID: 17916375)
Med Sci Sports Exerc. 2014 Sep;46(9):1816-24. (PMID: 24887173)
N Engl J Med. 1995 Nov 23;333(21):1369-73. (PMID: 7477116)
Br J Nutr. 2006 Feb;95(2):358-65. (PMID: 16469154)
BMC Gastroenterol. 2020 Oct 20;20(1):349. (PMID: 33081717)
J Nutr. 2011 May;141(5):903-13. (PMID: 21451127)
Br J Nutr. 2014 Dec 28;112(12):2041-8. (PMID: 25345663)
J Health Soc Behav. 1983 Dec;24(4):385-96. (PMID: 6668417)
ISME J. 2017 Dec;11(12):2639-2643. (PMID: 28731476)
J Agric Food Chem. 2022 Oct 26;70(42):13592-13601. (PMID: 36214842)
Cancer Sci. 2014 Jun;105(6):736-43. (PMID: 24673770)
ISME J. 2010 Jan;4(1):17-27. (PMID: 19710709)
Nutrients. 2019 May 17;11(5):. (PMID: 31108934)
J Pers Assess. 1985 Feb;49(1):71-5. (PMID: 16367493)
Clin Chem. 2003 Dec;49(12):2056-66. (PMID: 14633878)
Br J Nutr. 2016 Mar 28;115(6):1033-42. (PMID: 26856420)
Nutr Metab Cardiovasc Dis. 2022 Dec;32(12):2811-2821. (PMID: 36184364)
Yakugaku Zasshi. 2016;136(9):1255-62. (PMID: 27592828)
PLoS One. 2012;7(12):e52643. (PMID: 23285126)
Nutr Res. 2019 Nov;71:65-71. (PMID: 31757627)
Eur J Nutr. 2021 Mar;60(2):703-714. (PMID: 32435993)
BMJ Open Diabetes Res Care. 2015 Dec 01;3(1):e000147. (PMID: 26688736)
J Mol Neurosci. 2013 Oct;51(2):478-84. (PMID: 23955709)
J Sci Food Agric. 2015 Jul;95(9):1786-94. (PMID: 25270992)
Chin J Cancer Res. 2020 Dec 31;32(6):755-767. (PMID: 33446998)
Lipids Health Dis. 2012 May 14;11:52. (PMID: 22584034)
J Food Sci. 2021 Feb;86(2):602-613. (PMID: 33449409)
Psychopharmacol Bull. 1993;29(2):321-6. (PMID: 8290681)
Nutr Metab Cardiovasc Dis. 2014 Oct;24(10):1090-6. (PMID: 24909799)
J Affect Disord. 2021 Mar 1;282:41-45. (PMID: 33388472)
Nat Methods. 2018 Nov;15(11):847-848. (PMID: 30377368)
Am J Epidemiol. 1985 Jul;122(1):51-65. (PMID: 4014201)
Br J Clin Psychol. 2003 Jun;42(Pt 2):111-31. (PMID: 12828802)
BMC Bioinformatics. 2004 Aug 19;5:113. (PMID: 15318951)
Nutrients. 2016 Aug 27;8(9):. (PMID: 27618909)
J Nutr. 2002 Sep;132(9 Suppl):2920S-2926S. (PMID: 12221270)
Microbiome. 2018 May 17;6(1):90. (PMID: 29773078)
Int J Dermatol. 2003 Mar;42(3):178-81. (PMID: 12653910)
J Hypertens. 2019 Dec;37(12):2371-2379. (PMID: 31356404)
Nucleic Acids Res. 2004 Mar 19;32(5):1792-7. (PMID: 15034147)
Scand J Med Sci Sports. 2017 Dec;27(12):1814-1823. (PMID: 27878845)
Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288)
Teratology. 2000 Oct;62(4):214-26. (PMID: 10992263)
معلومات مُعتمدة: NA DSM Nutritional Products
فهرسة مساهمة: Keywords: Asian women; carotenoids; fecal microbiome; gene expression; mood; physical activity
المشرفين على المادة: 11103-57-4 (Vitamin A)
0 (Beta-Cryptoxanthin)
36-88-4 (Carotenoids)
01YAE03M7J (beta Carotene)
X72A60C9MT (Lutein)
0 (Zeaxanthins)
تواريخ الأحداث: Date Created: 20230527 Date Completed: 20230529 Latest Revision: 20230530
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10222860
DOI: 10.3390/nu15102325
PMID: 37242207
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu15102325