دورية أكاديمية
أعرض في EDS

Arylimidamides Have Potential for Chemoprophylaxis against Blood-Transmitted Chagas Disease.

التفاصيل البيبلوغرافية
العنوان: Arylimidamides Have Potential for Chemoprophylaxis against Blood-Transmitted Chagas Disease.
المؤلفون: Timm BL; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil., da Gama ANS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil., Batista DDGJ; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil., Boykin DW; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA., De Koning HP; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, UK., Correia Soeiro MN; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil.
المصدر: Pathogens (Basel, Switzerland) [Pathogens] 2023 May 12; Vol. 12 (5). Date of Electronic Publication: 2023 May 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2012-
مستخلص: Chagas disease (CD) affects over 6 million people worldwide and can be transmitted iatrogenically. Crystal violet (CV) was previously used for pathogen reduction but has harmful side-effects. In the present study, three arylimidamides (AIAs) and CV were used to sterilize mice blood samples experimentally contaminated with bloodstream trypomastigotes (BT) of Trypanosoma cruzi , at non hemolytic doses. All AIAs were not toxic to mouse blood cells until the highest tested concentration (96 µM). The previous treatment of BT with the AIAs impaired the infection establishment of cardiac cell cultures. In vivo assays showed that pre-incubation of mouse blood samples with the AIAs and CV (96 µM) significantly suppressed the parasitemia peak, but only the AIA DB1831 gave ≥90% animal survival, while vehicle treated samples reached 0%. Our findings support further studies regarding the potential use of AIAs for blood bank purposes.
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معلومات مُعتمدة: PAEF Oswaldo Cruz Foundation; 302160/2019-1 and 404166/2021-0 National Council for Scientific and Technological Development; E26/202925/2017 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
فهرسة مساهمة: Keywords: Chagas disease; Trypanosoma cruzi; arylimidamides; blood bank; chemoprophylaxis
تواريخ الأحداث: Date Created: 20230527 Latest Revision: 20230530
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10224031
DOI: 10.3390/pathogens12050701
PMID: 37242371
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-0817
DOI:10.3390/pathogens12050701