دورية أكاديمية
أعرض في EDS

Margaritaria nobilis L.f. (Phyllanthaceae) Ethanolic Extract: Low Acute Oral Toxicity and Antinociceptive Activity.

التفاصيل البيبلوغرافية
العنوان: Margaritaria nobilis L.f. (Phyllanthaceae) Ethanolic Extract: Low Acute Oral Toxicity and Antinociceptive Activity.
المؤلفون: Camara FMS; Laboratory of Inflammation and Behavioral Pharmacology (Lafico), Health Science Institute, Federal University of Pará, Belém 66075110, PA, Brazil., da Conceição BC; Laboratory of Inflammation and Behavioral Pharmacology (Lafico), Health Science Institute, Federal University of Pará, Belém 66075110, PA, Brazil.; Pharmaceutical Sciences Post-Graduation Program, Health Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., Cardoso EKS; Laboratory of Inflammation and Behavioral Pharmacology (Lafico), Health Science Institute, Federal University of Pará, Belém 66075110, PA, Brazil.; Pharmaceutical Sciences Post-Graduation Program, Health Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., Santiago JCC; Laboratory of Liquid Chromatography (Labcrol), Exact and Natural Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., Albuquerque CAB; Laboratory of Liquid Chromatography (Labcrol), Exact and Natural Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., Pereira WL; Animal Pathology Laboratory, Amazon Federal Rural University, Belém 66077830, PA, Brazil., Monteiro MC; Pharmaceutical Sciences Post-Graduation Program, Health Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., Yoshioka E Silva CY; Pharmaceutical Sciences Post-Graduation Program, Health Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil.; Laboratory of Liquid Chromatography (Labcrol), Exact and Natural Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., da Silva MN; Pharmaceutical Sciences Post-Graduation Program, Health Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil.; Laboratory of Liquid Chromatography (Labcrol), Exact and Natural Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., Maia CF; Laboratory of Inflammation and Behavioral Pharmacology (Lafico), Health Science Institute, Federal University of Pará, Belém 66075110, PA, Brazil.; Pharmaceutical Sciences Post-Graduation Program, Health Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil., Fontes-Junior EA; Laboratory of Inflammation and Behavioral Pharmacology (Lafico), Health Science Institute, Federal University of Pará, Belém 66075110, PA, Brazil.; Pharmaceutical Sciences Post-Graduation Program, Health Sciences Institute, Federal University of Pará, Belém 66075110, PA, Brazil.
المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 May 03; Vol. 16 (5). Date of Electronic Publication: 2023 May 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2004-
مستخلص: Margaritaria nobilis L.f. (Phyllanthaceae), a native Brazilian tree occurring mainly in the Amazon, is used in folk medicine for the treatment of abscesses (bark) and cancer-like symptoms (leaves). The present study evaluates the safety of its acute oral administration and its effects on nociception and plasma leakage. The chemical constitution of the leaf's ethanolic extract is determined by ultra-performance liquid chromatography-high-resolution mass spectrometry (LC-MS. Its acute oral toxicity is evaluated in female rats at a dose of 2000 mg/kg, evaluating the occurrence of deaths and Hippocratic, behavioral, hematological, biochemical, and histopathological changes, as well as food and water consumption and weight gain. Antinociceptive activity is evaluated in male mice with acetic-acid-induced peritonitis (APT) and formalin (FT) tests. An open field (OF) test is performed to verify possible interferences in the animals' consciousness or locomotion. LC-MS analysis shows the presence of 44 compounds classified as phenolic acid derivatives, flavonoids and O-glycosylated derivatives, and hydrolyzable tannins. No deaths or significant behavioral, histological, or biochemical changes are observed in the toxicity assessment. In nociception tests, M. nobilis extract significantly reduces abdominal contortions in APT, demonstrating selectivity for inflammatory components (FT second phase), not interfering in neuropathic components (FT first phase) or consciousness and locomotion levels in OF. Additionally, M. nobilis extract inhibits plasma acetic-acid-induced leakage. These data demonstrate the low toxicity of M. nobilis ethanolic extract, as well as its effectiveness in modulating inflammatory nociception and plasma leakage, possibly related to the flavonoids and tannins present in its composition.
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معلومات مُعتمدة: EDITAL 01/2023 - PROPESP Federal University of Para; PRO463-2017 Federal University of Para
فهرسة مساهمة: Keywords: Margaritaria nobilis; antinociceptive; medicinal plants; natural products; nociception; pain; toxicity
تواريخ الأحداث: Date Created: 20230527 Latest Revision: 20230529
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10221426
DOI: 10.3390/ph16050689
PMID: 37242472
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8247
DOI:10.3390/ph16050689