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Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF-κB pathway: Molecular docking and biological investigations.

التفاصيل البيبلوغرافية
العنوان: Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF-κB pathway: Molecular docking and biological investigations.
المؤلفون: ElSayed MH; Department of Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Atif HM; Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Eladl MA; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates., Elaidy SM; Clinical Pharmacology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt., Helaly AMN; Department of Forensic Medicine and Toxicology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Hisham FA; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Farag NE; Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt., Osman NMS; Department of Anatomy, Faculty of Medicine, Port Said University, Port Said, Egypt., Ibrahiem AT; Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Khella HWZ; Department of Clinical Education, Canadian Memorial Chiropractic College, Toronto, ON M2H 3J1, Canada., Bilasy SE; Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; College of Dental Medicine, California Northstate University, 9700 Taron Dr., Elk Grove, CA 95757, USA., Albalawi MA; Department of chemistry, Alwajh College, University of Tabuk, Tabuk 71491, Saudi Arabia., Helal MA; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza 12587, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt., Alzlaiq WA; Department of Clinical Pharmacy, College of Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Zaitone SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. Electronic address: szaitone@ut.edu.saz.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Aug; Vol. 164, pp. 114917. Date of Electronic Publication: 2023 May 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: Parkinsonian Disorders*/chemically induced , Parkinsonian Disorders*/drug therapy , Parkinsonian Disorders*/metabolism , Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism, Male ; Mice ; Animals ; NF-kappa B/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Toll-Like Receptor 4/metabolism ; Molecular Docking Simulation ; Down-Regulation ; Rotenone/adverse effects ; Betacyanins/pharmacology ; Malondialdehyde
مستخلص: Parkinson's disease (PD) is a progressive neuroinflammatory and degenerative disease. In this study, we investigated the neuroprotective action of betanin in the rotenone-induced Parkinson-like mice model. Twenty-eight adult male Swiss albino mice were divided into four groups: Vehicle, Rotenone, Rotenone + Betanin 50 mg/kg, and Rotenone + Betanin 100 mg/kg. Parkinsonism was induced by subcutaneous injection of 9 doses of rotenone (1 mg/kg/48 h) plus betanin at 50 and 100 mg/kg/48 h in rotenone + betanin groups for twenty days. Motor dysfunction was assessed after the end of the therapeutic period using the pole, rotarod, open-field, grid, and cylinder tests. Malondialdehyde, reduced glutathione (GSH), Toll-like receptor 4 (TLR4), myeloid differentiation primary response-88 (MyD88), nuclear factor kappa- B (NF-κB), neuronal degeneration in the striatum were evaluated. In addition, we assessed the immunohistochemical densities of tyrosine hydroxylase (TH) in Str and in substantia nigra compacta (SNpc). Our results showed that rotenone remarkably decreased (results of tests), increased decreased TH density with a significant increase in MDA, TLR4, MyD88, NF-κB, and a decrease in GSH (p < 0.05). Treatment with betanin significantly results of tests), increased TH density. Furthermore, betanin significantly downregulated malondialdehyde and improved GSH. Additionally, the expression of TLR4, MyD88, and NF-κB was significantly alleviated. Betanin's powerful antioxidative and anti-inflammatory properties can be related to its neuroprotective potential as well as its ability to delay or prevent neurodegeneration in PD.
Competing Interests: Declaration of Competing Interest Authors declares they have no potential conflicts of interests.
(Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: Betanin; Experimental Parkinsonism; Molecular docking; Mouse; TLR4/MyD88/NF-κB pathway
المشرفين على المادة: 0 (NF-kappa B)
0 (Myeloid Differentiation Factor 88)
0 (Toll-Like Receptor 4)
03L9OT429T (Rotenone)
5YJC992ZP6 (betanin)
0 (Betacyanins)
4Y8F71G49Q (Malondialdehyde)
تواريخ الأحداث: Date Created: 20230527 Date Completed: 20230622 Latest Revision: 20230622
رمز التحديث: 20230622
DOI: 10.1016/j.biopha.2023.114917
PMID: 37244180
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2023.114917