دورية أكاديمية
Using urinary metabolomics to identify metabolic pathways linked to cardiac structural alterations in young adults: The African-PREDICT study.
| العنوان: | Using urinary metabolomics to identify metabolic pathways linked to cardiac structural alterations in young adults: The African-PREDICT study. |
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| المؤلفون: | du Toit WL; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa., Kruger R; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Gafane-Matemane LF; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Schutte AE; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa; School of Population Health, University of New South Wales, The George Institute for Global Health, Sydney, Australia., Louw R; Human Metabolomics, North-West University, Potchefstroom Campus, Potchefstroom, South Africa., Mels CMC; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. Electronic address: carina.mels@nwu.ac.za. |
| المصدر: | Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2023 Aug; Vol. 33 (8), pp. 1574-1582. Date of Electronic Publication: 2023 May 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111474 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3729 (Electronic) Linking ISSN: 09394753 NLM ISO Abbreviation: Nutr Metab Cardiovasc Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Original Publication: [Heidelberg] : Springer International, c1991- |
| مواضيع طبية MeSH: | Creatine* , Hypertension*, Humans ; Young Adult ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/epidemiology ; Risk Factors ; Metabolomics ; Metabolic Networks and Pathways |
| مستخلص: | Background and Aims: Risk factor exposure from young ages was shown to contribute to cardiovascular events - cardiac hypertrophy, which may be accompanied by an altered metabolism. To determine how early metabolic alterations associate with myocardial structural changes, we profiled urinary metabolites in young adults with cardiovascular disease (CVD) risk factor(s) and a control group without CVD risk factors. Methods and Results: We included healthy adults (N = 1202), aged 20-30 years, stratified based on risk factors, i.e., obesity, physical inactivity, elevated blood pressure (BP), hyperglycemia, dyslipidemia, low socio-economic status, smoking and excessive alcohol use - forming the CVD risk group (N = 1036) and the control group (N = 166). Relative wall thickness (RWT) and left ventricular mass index (LVMi) were measured using echocardiography. Targeted metabolomics data were obtained using a liquid chromatography-tandem mass spectrometry method. Clinic systolic BP, 24 h BP and RWT were higher in the CVD risk group compared to the control group (all P ≤ 0.031). Exclusively in the CVD risk group, RWT associated with creatine and dodecanoylcarnitine; while LVMi associated with glycine, serine, glutamine, threonine, alanine, citrulline, creatine, proline, pyroglutamic acid and glutamic acid (all P ≤ 0.040). Exclusively in the control group, LVMi associated with propionylcarnitine and butyrylcarnitine (all P ≤ 0.009). Conclusion: In young adults without CVD, but with CVD risk factors, LVMi and RWT associated with metabolites linked energy metabolism (shifting from solely fatty acid oxidation to glycolysis, with impaired creatine kinase activity) and oxidative stress. Our findings support early onset metabolic changes accompanying cardiac structural alterations due to lifestyle and behavioural risk factors. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cardiac hypertrophy; Cardiovascular disease; Left ventricular mass index; Relative wall thickness; Risk factors |
| المشرفين على المادة: | MU72812GK0 (Creatine) |
| تواريخ الأحداث: | Date Created: 20230528 Date Completed: 20230710 Latest Revision: 20231116 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.numecd.2023.05.010 |
| PMID: | 37246075 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1590-3729 |
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| DOI: | 10.1016/j.numecd.2023.05.010 |