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Quercus coccinea Münchh leaves polyphenols: Appraisal acute lung injury induced by lipopolysaccharide in mice.

التفاصيل البيبلوغرافية
العنوان: Quercus coccinea Münchh leaves polyphenols: Appraisal acute lung injury induced by lipopolysaccharide in mice.
المؤلفون: El-Sayed EK; Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt., Ibrahim RR; Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt., Ahmed AA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt., Khattab MA; Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Chen LY; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan., Lai KH; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan; PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan. Electronic address: kueihunglai@tmu.edu.tw., Shaarawy FSE; Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt., Tawfik NF; Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt., Moharram FA; Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Aug; Vol. 164, pp. 114765. Date of Electronic Publication: 2023 May 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: Quercus* , Acute Lung Injury*/chemically induced , Acute Lung Injury*/drug therapy , Acute Lung Injury*/metabolism, Mice ; Animals ; Lipopolysaccharides/pharmacology ; Polyphenols/adverse effects ; NF-kappa B/metabolism ; Antioxidants/metabolism ; Anti-Inflammatory Agents/adverse effects ; Plant Leaves
مستخلص: Genus Quercus is a well-known source for its polyphenolic content and important biological activity. Plants belonging to the Quercus genus were traditionally used in asthma, inflammatory diseases, wound healing, acute diarrhea, and hemorrhoid. Our work intended to study the polyphenolic profile of the Q. coccinea (QC) leaves and to assess the protective activity of its 80% aqueous methanol extract (AME) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Together, the potential molecular mechanism was investigated. Nineteen polyphenolic compounds (1-18), including tannins, flavone, and flavonol glycosides. Phenolic acids and aglycones were purified and identified from the AME of QC leaves. Treatment with AME of QC showed an anti-inflammatory effect evidenced by a remarkable decline in the count of white blood cells and neutrophils which was in harmony with decreasing the levels of high mobility group box-1, nuclear factor kappa B, tumor necrosis factor-α, and interleukin 1 beta. In addition, the antioxidant activity of QC was documented through the significant reduction in malondialdehyde level and elevation of reduced glutathione level and superoxide dismutase activity. Furthermore, the mechanism involved in the pulmonary protective effect of QC involved the downregulation of the TLR4/MyD88 pathway. The AME of QC showed a protective effect against LPS-induced ALI through the powerful anti-inflammatory and antioxidant activities which are linked to its abundancy with polyphenols.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: Anti-inflammatory; Lipopolysaccharide; Lung injury; NF-κB; Oxidative stress; Polyphenols; Quercus coccinea; TLR4
المشرفين على المادة: 0 (Lipopolysaccharides)
0 (Polyphenols)
0 (NF-kappa B)
0 (Antioxidants)
0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20230528 Date Completed: 20230622 Latest Revision: 20230622
رمز التحديث: 20230622
DOI: 10.1016/j.biopha.2023.114765
PMID: 37246132
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2023.114765