دورية أكاديمية
أعرض في EDS

Formamide-based production of amines by metabolically engineering Corynebacterium glutamicum.

التفاصيل البيبلوغرافية
العنوان: Formamide-based production of amines by metabolically engineering Corynebacterium glutamicum.
المؤلفون: Schwardmann LS; Genetics of Prokaryotes, Faculty of Biology and CeBiTec, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany., Wu T; Department of Biochemistry, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Charitéplatz 1, 10117, Berlin, Germany., Dransfeld AK; Genetics of Prokaryotes, Faculty of Biology and CeBiTec, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany., Lindner SN; Department of Biochemistry, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Charitéplatz 1, 10117, Berlin, Germany., Wendisch VF; Genetics of Prokaryotes, Faculty of Biology and CeBiTec, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany. volker.wendisch@uni-bielefeld.de.
المصدر: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2023 Jul; Vol. 107 (13), pp. 4245-4260. Date of Electronic Publication: 2023 May 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York : Springer International, c1984-
مواضيع طبية MeSH: Lysine*/metabolism , Corynebacterium glutamicum*/metabolism, Amines/metabolism ; Amino Acids/metabolism ; Nitrogen/metabolism ; Metabolic Engineering
مستخلص: Formamide is rarely used as nitrogen source by microorganisms. Therefore, formamide and formamidase have been used as protection system to allow for growth under non-sterile conditions and for non-sterile production of acetoin, a product lacking nitrogen. Here, we equipped Corynebacterium glutamicum, a renowned workhorse for industrial amino acid production for 60 years, with formamidase from Helicobacter pylori 26695, enabling growth with formamide as sole nitrogen source. Thereupon, the formamide/formamidase system was exploited for efficient formamide-based production of the nitrogenous compounds L-glutamate, L-lysine, N-methylphenylalanine, and dipicolinic acid by transfer of the formamide/formamidase system to established producer strains. Stable isotope labeling verified the incorporation of nitrogen from formamide into biomass and the representative product L-lysine. Moreover, we showed ammonium leakage during formamidase-based access of formamide to be exploitable to support growth of formamidase-deficient C. glutamicum in co-cultivation and demonstrated that efficient utilization of formamide as sole nitrogen source benefitted from overexpression of formate dehydrogenase. KEY POINTS: • C. glutamicum was engineered to access formamide. • Formamide-based production of nitrogenous compounds was established. • Nitrogen cross-feeding supported growth of a formamidase-negative strain.
(© 2023. The Author(s).)
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معلومات مُعتمدة: ForceYield (031B0825C) Bundesministerium für Bildung und Forschung; BMBF project ForceYield (031B0825B) Bundesministerium für Bildung und Forschung
فهرسة مساهمة: Keywords: Amine production; Co-cultivation; Corynebacterium glutamicum; Formamidase; Formamide
المشرفين على المادة: K3Z4F929H6 (Lysine)
0 (Amines)
0 (Amino Acids)
N762921K75 (Nitrogen)
تواريخ الأحداث: Date Created: 20230529 Date Completed: 20230703 Latest Revision: 20230714
رمز التحديث: 20230714
مُعرف محوري في PubMed: PMC10313556
DOI: 10.1007/s00253-023-12592-3
PMID: 37246985
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0614
DOI:10.1007/s00253-023-12592-3