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A Patent Review on SARS Coronavirus Papain-Like Protease (PL pro ) Inhibitors.

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العنوان: A Patent Review on SARS Coronavirus Papain-Like Protease (PL pro ) Inhibitors.
المؤلفون: Brian Chia CS; Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10 Biopolis Road, Chromos #08-01, Singapore, 138670, Singapore., Pheng Lim S; Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10 Biopolis Road, Chromos #08-01, Singapore, 138670, Singapore.
المصدر: ChemMedChem [ChemMedChem] 2023 Aug 15; Vol. 18 (16), pp. e202300216. Date of Electronic Publication: 2023 Jun 15.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2006-
مواضيع طبية MeSH: Papain* , COVID-19*, Humans ; Peptide Hydrolases ; Coronavirus Papain-Like Proteases ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Protease Inhibitors/pharmacology
مستخلص: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is an unprecedented global health emergency causing more than 6.6 million fatalities by 31 December 2022. So far, only three antiviral drugs have been granted emergency use authorisation or approved by the FDA. The SARS-CoV-2 papain-like protease (PL pro ) is deemed an attractive drug target as it plays an essential role in viral polyprotein processing and pathogenesis although no inhibitors have yet been approved. This patent review discusses coronavirus PL pro inhibitors reported in patents published between 1 January 2003 to 2 March 2023, giving an overview on the inhibitors that have generated commercial interest, especially amongst drug companies.
(© 2023 Wiley-VCH Verlag GmbH.)
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فهرسة مساهمة: Keywords: COVID-19, cysteine protease inhibitors; PLpro; SARS-CoV-2; papain-like protease
المشرفين على المادة: EC 3.4.22.2 (Papain)
EC 3.4.- (Peptide Hydrolases)
EC 3.4.22.2 (Coronavirus Papain-Like Proteases)
0 (Antiviral Agents)
0 (Protease Inhibitors)
تواريخ الأحداث: Date Created: 20230529 Date Completed: 20230818 Latest Revision: 20230826
رمز التحديث: 20230827
DOI: 10.1002/cmdc.202300216
PMID: 37248169
قاعدة البيانات: MEDLINE
الوصف
تدمد:1860-7187
DOI:10.1002/cmdc.202300216